Biodegradable Periodic Mesoporous Organosilica (BPMO) Loaded with Daunorubicin: A Promising Nanoparticle‐Based Anticancer Drug

Abstract

Biodegradable periodic mesoporous organosilica (BPMO) nanoparticles have emerged as a promising type of nanocarrier for drug delivery, given the biodegradable feature is advantageous for clinical translation. In this paper, we report synthesis and characterization of daunorubicin (DNR) loaded BPMO. DNR was loaded onto rhodamine B‐labeled BPMO that contain tetrasulfide bonds. Tumor spheroids and chicken egg tumor models were used to characterize the activity in biological settings. In the first experiment we examined the uptake of BPMO into tumor spheroids prepared from ovarian cancer cells. BPMO were efficiently taken up into tumor spheroids and inhibited their growth. In the chicken egg tumor model, intravenous injection of DNR‐loaded BPMO led to the elimination of ovarian tumor. Lack of adverse effect on organs such as lung appears to be due to excellent tumor accumulation of BPMO. Thus, DNR‐loaded BPMO represents a promising nanodrug compared with free DNR currently used in cancer therapy. OK

Recent Development to Explore the Use of Biodegradable Periodic Mesoporous Organosilica (BPMO) Nanomaterials for Cancer Therapy

“…A very good accumulation of BPMO in the chicken egg model was observed, and this increased the uptake of the drug with a less toxic side effect. DNR BPMOs will be very good clinical candidates in the future [39].…”

“…(c) Dynamic light scattering (DLS) measurements confirmed the average size of pristine BPMOs and degraded fragments after 3 days of treatment. Adapted from[39], Wiley Publications, 2020.…”

Trends in Degradable Mesoporous Organosilica-Based Nanomaterials for Controlling Drug Delivery: A Mini Review

“…Furthermore, PMOs can be designed to present maximum cargo uptake efficiency without the extra usage of stimuli-responsive gates to block the pores, by possible interactions between the drug units and the organic components created in the nanoparticle’s surface [ 61 , 62 ]. Very recently, other promising biodegradable periodic mesoporous organosilica (BPMO) nanoparticles were prepared by using tetrasulfide units [ 63 ]. These particles potentially degraded under reducing conditions at higher glutathione concentrations.…”

“…( b ) Bright field and fluorescence images indicate the preferential accumulation of the BPMOs in the tumor, expressing green or red fluorescent protein (GFP and RFP, respectively); ( c ) Optical image of ovarian tumor spheroid; ( d ) calculated spheroid volume after treatment with no injection (Control), free BPMO nanoparticles, free daunorubicin (DNR) or DNR-BPMO nanoparticles over a period of 7 days. Scale bar: 100 μm Reproduced from [ 63 ] ( ) with permission from Wiley-VCH.…”

Convergence of the Study on Monochromatic X-rays and the Research on Nanoparticles Opens Up a Possibility to Develop a New Type of Radiation Therapy

“…MSN nanoparticles were surface modified so that they have excellent dispersibility in a solution. One of the ways to accomplish this is to use phosphonate to provide negative charge to the nanoparticle surface [33]. Gadolinium was attached to MSN by first preparing amine modified MSN by using APTES and then incubated with gadopentetic acid to prepare Gd-MSN [9].…”