Biodegradable pH- and temperature-sensitive multiblock copolymer hydrogels based on poly(amino-ester urethane)s

Zheng, Yongtai; He, Chaoliang; Huynh, Cong Truc; Lee, Sang Soo

doi:10.1007/s13233-010-1002-2

Cited by 24 publications

(29 citation statements)

References 34 publications

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“…Hydrogels synthesized from PEG and -caprolactone co-polymers are shown to be hydrolytically degradable, but the degradation rate is limited by the hydrophobicity and phase separation of -caprolactone segments in solution [67]. In addition to poly(aliphatic hydroxy acids), other hydrolytically degradable polymers including poly(ester amides) [68], polyphosphoesters [69,70], poly(amino-ester urethanes) [71] are used to synthesize degradable hydrogels. Photodegradable hydrogels are synthesized by incorporation of nitrobenzyl ether-derived moieties in PEG based hydrogels [72].…”

Section: Degradation Of Micellar Gelsmentioning

confidence: 99%

Gelation characteristics, physico-mechanical properties and degradation kinetics of micellar hydrogels

Moeinzadeh

Jabbari

2015

European Polymer Journal

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Due to their high water content and diffusivity of nutrients and biomolecules, hydrogels are very attractive as a matrix for growth factor immobilization and in situ delivery of cells to the site of regeneration in tissue engineering. The formation of micellar structures at the nanoscale in hydrogels alters the spatial distribution of the reactive groups and affects the rate and extent of crosslinking and mechanical properties of the hydrogel. Further, the degradation rate of a hydrogel is strongly affected by the proximity of water molecules to the hydrolytically degradable segments at the nanoscale. The objective of this review is to summarize the unique properties of micellar hydrogels with a focus on our previous work on star polyethylene glycol (PEG) macromonomers chain extended with short aliphatic hydroxy acid (HA) segments (SPEXA hydrogels). Micellar SPEXA hydrogels have faster gelation rates and higher compressive moduli compared to their non-micellar counterpart. Owing to their micellar structure, SPEXA hydrogels have a wide range of degradation rates from a few days to many months as opposed to non-degradable PEG gels while both gels possess similar water contents. Furthermore, the viability and differentiation of mesenchymal stem cells (MSCs) is enhanced when the cells are encapsulated in degradable micellar SPEXA gels compared with those cells encapsulated in non-micellar PEG gels.

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Section: Degradation Of Micellar Gelsmentioning

confidence: 99%

Gelation characteristics, physico-mechanical properties and degradation kinetics of micellar hydrogels

Moeinzadeh

Jabbari

2015

European Polymer Journal

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“…16,[35][36][37][38][39][40] Copolymers were dissolved in 10 mM phosphate buffered saline solution at pH 1 (PBS, adjusted using 5 N HCl) in 4 mL vials (10 mm diameter, $0.5 mL per vial) at a given concentration for 2-4 h. The pH of the solutions was adjusted to desired values using 5 N NaOH and 5 N HCl at 0 C and stabilized at 2 C overnight. 16,[35][36][37][38][39][40] Copolymers were dissolved in 10 mM phosphate buffered saline solution at pH 1 (PBS, adjusted using 5 N HCl) in 4 mL vials (10 mm diameter, $0.5 mL per vial) at a given concentration for 2-4 h. The pH of the solutions was adjusted to desired values using 5 N NaOH and 5 N HCl at 0 C and stabilized at 2 C overnight.…”

Section: Sol-gel Phase Transition Measurementmentioning

confidence: 99%

“…16,[35][36][37][38][39][40] As shown in Fig. The sol state of polymer solution allows homogenous formulation with bioactive molecules, and the sol-to-gel phase transition guarantees that the injected hydrogel precursor solution forms the hydrogel depot for subsequently controlled release of loaded bioactive molecules.…”

Section: Sol-gel Phase Transitionmentioning

confidence: 99%

“…Temperature-sensitive self-assembled hydrogels have been widely investigated for their potential applications in biomedical engineering, including copolymers based on poly(ethylene glycol) (PEG), [17][18][19] poly(D,L lactide), 20,21 poly(lactide-co-glycolide) (PLGA), 16,[22][23][24] poly(caprolactone) (PCL), 25 poly(caprolactone-co-lactide) (PCLA), 26 poly(trimethylene carbonate) (PTMC), 27 poly(phosphazene), 28 and natural polymers. Ionic copolymers based on poly(b-amino ester) (PAE), 31 poly(amido amine) (PAA), 32 poly(b-amino urethane) (PAU), 33 poly(b-amino urea urethane) (PAUU), 34 poly(b-amino ester urethane) (PAEU), [35][36][37][38][39][40] chitosan, [41][42][43] polypicolyamine, 44 and polysulfamethazine 45,46 have been widely investigated as hydrogel systems for the delivery of genes, proteins, growth factors, and anticancer drugs. pH/ temperature-sensitive polymers containing ionic functional groups further offer electrostatic interaction with ionic bioactive molecules.…”

Section: Introductionmentioning

confidence: 99%

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Intraarterial gelation of injectable cationic pH/temperature-sensitive radiopaque embolic hydrogels in a rabbit hepatic tumor model and their potential application for liver cancer treatment

et al. 2016

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Poly(amino ester urethane) (PAEU) block copolymers have been reported as potential hydrogel systems for drug delivery because of such advantages as their non-toxicity, ability to form electrostatic linkages and hydrogen bonds with bioactive agents, and ability to exhibit a sol-to-gel phase transition after injection into the body to form a hydrogel to act as a depot for the subsequent controlled release of loaded bioactive molecules. In this study, PAEU bock copolymers were synthesized, and their chemical structures and properties were characterized. In aqueous solution, the copolymers exhibited a sol-to-gel phase transition with increasing pH, or a gel-to-sol phase transition with increasing temperature. The formation of in situ gels has been observed within 20 min of subcutaneous injection of copolymer solutions into SD rats due to the sol-to-gel phase transition which occurs in response to local pH and temperature. The prepared polymers were employed for the fabrication of injectable radiopaque embolic materials, which are mixtures of an aqueous copolymer solution and a commercial long-lasting X-ray contrast agent, Lipiodol. The formulated radiopaque embolic hydrogel precursor solutions were then intraarterialy injected via the hepatic arteries feeding the VX2 hepatic tumors in rabbits using a 2.0 Fr microcatheter to investigate their gelability for potential application in liver cancer treatment. CT images and histological examination of excised tumor tissues confirmed the formation of hydrogels in the hepatic arteries and tumors. Doxorubicin (DOX), an anticancer drug, was released from hydrogels with or without Lipiodol in sustained fashion, and the released DOX fully retained its bioactivity via inhibiting the proliferation of cancer cells in vitro. These results have demonstrated that the synthesized PAEU block copolymers can be used to prepare radiopaque embolic solutions, which then exhibit a solto-gel phase transition to form hydrogels acting as anticancer drug depots to induce chemoembolization after being injected into tumor-feeding arteries, and therefore offer potential applications for TACE in liver cancer.A 500 MHz spectrometer (Varian Unity Inova 500NB, Varian Inc., USA) was used to record the proton NMR of the HBP monomer and synthesized copolymers using CDCl 3 as a solvent. 47688 | RSC Adv., 2016, 6, 47687-47697 This journal isFig. 10 (A) Digital images of the excised tumors (inside yellow circles) at 5 h after intraarterial injection, (B) and (C) H&E staining of the harvested tumors (arrow-indicated gel regions) of (1) formulation D1 and (2) formulation D2.This journal is

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“…The degradation and water content of the copolymers can be adjusted by the fraction of hydrophobic lactide segments [131,132] but solubility of the copolymer in aqueous solution was adversely affected by increasing the lactide content [133]. In addition, other hydrolytically degradable polymers including polyphosphoesters [134,135], poly(ester amides) [136] and poly(amino-ester urethanes) [137] have been used to synthesize degradable hydrogels. Degradable micellar hydrogels with a wide range of degradation rate have been synthesized using star-shape PEG macromers chain-extended with short hydroxy acid segments [104,108,118].…”

Section: Degradationmentioning

confidence: 99%

Hydrogels for Cell Encapsulation and Bioprinting

Shariati

Moeinzadeh

Jabbari

2015

Bioprinting in Regenerative Medicine

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Resumo: An in vitro encapsulation platform utilizing hydrogels and bone matrix (BM) scaffolds to investigate the effects of microenvironmental parameters on encapsulated goat mesenchymal stem cells (gMSC) was presented. The base encapsulation matrix was composed of a biocompatible hydrogel formed through a photoinitiated polymerization process. Different polymer concentrations were used to compare the effects of hydrogel crosslinking density on physical properties, as well as on cell viability. The potential of BM to support the growth and differentiation of gMSC was also analyzed. Both methods were compared in order to analyze viability. Structures that better allow flow of oxygen showed more promising results, whereas BM structures require a better evaluation method for concrete results.

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Biodegradable pH- and temperature-sensitive multiblock copolymer hydrogels based on poly(amino-ester urethane)s

Cited by 24 publications

References 34 publications

Gelation characteristics, physico-mechanical properties and degradation kinetics of micellar hydrogels

Gelation characteristics, physico-mechanical properties and degradation kinetics of micellar hydrogels

Intraarterial gelation of injectable cationic pH/temperature-sensitive radiopaque embolic hydrogels in a rabbit hepatic tumor model and their potential application for liver cancer treatment

Hydrogels for Cell Encapsulation and Bioprinting

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