Biodegradable phenylboronic acid-modified ε-polylysine for glucose-responsive insulin delivery <i>via</i> transdermal microneedles

Shen, Di; Yu, Haojie; Chen, Xiang; Feng, Jingyi; Zhang, Qian; Wei, Xicheng; Pan, Jin; Yin, Hang; Liu, Xiaowei

doi:10.1039/d1tb00880c

Cited by 32 publications

(70 citation statements)

References 53 publications

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“…Three different PCL- b -PFPBA with FPBA/Lys (mol/mol) ratios of 30, 43, and 57% were used, and the as-prepared CMs were denoted as CMs-L, CMs-M, and CMs-H, respectively (Table S1). PFPBA is soluble in alkaline aqueous solution but became insoluble at pH 7.4 because of the transformation of FPBA from a negatively charged tetrahedral form to a neutral triangle form. , This induced microphase separation in the mixed PEG/PFPBA shell and resulted in the formation of hydrophobic domains on the surface of the PCL core because of the collapse of PFPBA chains. The hydrophilic PEG surrounded the PCL core and sterically stabilized the micelles.…”

Section: Resultsmentioning

confidence: 99%

Glucose-Responsive Nanochaperones Mediate Exendin-4 Delivery for Enhancing Therapeutic Effects

Yang

Dèng

et al. 2022

ACS Appl. Mater. Interfaces

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Exendin-4 (Ex-4) is a promising therapeutic peptide for the clinical treatment of type 2 diabetes, but its instability and immunogenicity result in a short circulating half-life and low bioavailability, which severely limit its clinical application. Here, complex micelles with 4-carboxy-3-fluorophenylboronic acid (FPBA)-modified and positively charged hydrophobic domains on the surface were devised as nanochaperones to mediate the delivery of Ex-4. The nanochaperones can bind Ex-4 on the surface via the synergy of electrostatic and hydrophobic interactions, leading to efficient loading and stabilization of Ex-4. More importantly, the immunogenic site of Ex-4 was shielded by the nanochaperones, thereby effectively reducing the immune clearance and prolonging the half-life. Hyperglycemia-triggered release of Ex-4 was achieved by the hydrophobic to the hydrophilic transformation of the FPBA-modified domains and the introduced negative charge because of the binding of glucose by FPBA. The Ex-4-loaded nanochaperones exhibited an enhanced therapeutic effect on type 2 diabetic mice.

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Section: Resultsmentioning

confidence: 99%

Glucose-Responsive Nanochaperones Mediate Exendin-4 Delivery for Enhancing Therapeutic Effects

Yang

Dèng

et al. 2022

ACS Appl. Mater. Interfaces

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“…The modeling method of type I diabetic rats and full-thickness excisional circular wound are outlined our group’s previous work . In detail, 50 mg/kg of STZ was used to induced diabetic SD rats (200–220 g) per day via intraperitoneal injection until the blood glucose levels reached 300 mg dL –1 .…”

Section: Methodsmentioning

confidence: 99%

“…The modeling method of type I diabetic rats and full-thickness excisional circular wound are outlined our group's previous work. 40 In detail, 50 mg/kg of STZ was used to induced diabetic SD rats (200−220 g) per day via intraperitoneal injection until the blood glucose levels reached 300 mg dL −1 . After 1 week of stabilization, the rats were anesthetized, and 4 round full-thickness wounds were created on the back of rats using a puncher.…”

Section: Minimum Inhibitory Concentrationmentioning

confidence: 99%

Multistage ROS-Responsive and Natural Polyphenol-Driven Prodrug Hydrogels for Diabetic Wound Healing

Huang

et al. 2022

ACS Appl. Mater. Interfaces

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The high level of reactive oxygen species (ROS) and bacterial infection impede wound healing of the diabetic wound. Here, benefiting from the antioxidation effects of tannic acid (TA) and ROS-responsive phenylborate ester (PBAE), a series of ROS-responsive anti-inflammatory TA-conjugated nanoparticle hydrogels (PPBA-TA-PVA) can be obtained by conveniently mixing TA, phenylboric acid modified polyphosphazene (PPBA), and poly(vinyl alcohol) (PVA). The obtained PPBA-TA-PVA hydrogels could effectively inhibit the growth of Escherichia coli (antibacterial rate = 93.1 ± 1.1%) within 4 h and effectively scavenge both 2,2-diphenyl-1-picrylhydrazyl (DPPH) radicals and •OH radicals in vitro. Besides, the cell migration rate of HDFa cells treated with PPBA-TA-PVA hydrogels (84.2 ± 4.6%) was twice the rate of normal cells (43.8 ± 8.1%) after 24 h of cocultivation. The clinical relevance was demonstrated further by assessing the PPBA-TA-PVA hydrogels in full-thickness excisional wounds in a streptozotocin (STZ)-induced diabetic rat model. The PPBA-TA-PVA hydrogels could act as effective ROS-scavenging agents to alleviate inflammation and accelerate wound closure by decreasing the proinflammatory cytokines (IL-6, IL-1β) and increasing the gene expression of TGF-β1, COL-1, and COL-3, which resulted in faster re-epithelialization and increased formation of granulation tissue.

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“…The noncytotoxicity was evaluated by MTT assay and hemolysis test according to the previous work. [ 48 ]…”

Section: Methodsmentioning

confidence: 99%

Instant and Tough Adhesives for Rapid Gastric Perforation and Traumatic Pneumothorax Sealing

Liu

Yang

et al. 2022

Adv Healthcare Materials

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Hydrogel adhesives are hot spots due to their ubiquity and practical relevance. However, achieving a robust wet adhesion is still a challenge due to the preferential formation of hydrogen bonds between interfacial fluids and bulk hydrogel, as well as targeted substrates. Herein, a half‐dry adhesive consisting of a silk fibroin (SF) semi‐interpenetrating network and poly(acrylic acid) covalent network, which can allow a rapid liquid adsorption and repulsion process encountering a wet tissue, is reported. The remaining water enables excellent hydrogel flexibility to a dynamic surface, while the β‐sheet fold endows its tough bulk strength under the peeling‐off process. Notably, the wet adhesion energy versus porcine skin is 1440 J m−2 due to the combination of hydrogen bonds, electrostatic interactions, and chain entanglement derived from SF. In particular, both in vitro and in vivo outcomes indicate excellent hemostatic effects and result in incision closure of skin, artery, gastric perforation, and lung. After the first‐stage closure, polyacrylic‐silk fibroin adhesive (PSA) sealants can detach from the lung surface, fitting well to the healing period. By virtue of the reliable adhesion and good noncytotoxicity, PSA may be a prospective candidate for tissue sealant and drug carrier applications.

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Biodegradable phenylboronic acid-modified ε-polylysine for glucose-responsive insulin delivery via transdermal microneedles

Abstract: Microneedles with insulin-loaded glucose-responsive particles are promising to control the blood glucose levels of diabetic patients.

Cited by 32 publications

References 53 publications

Glucose-Responsive Nanochaperones Mediate Exendin-4 Delivery for Enhancing Therapeutic Effects

Glucose-Responsive Nanochaperones Mediate Exendin-4 Delivery for Enhancing Therapeutic Effects

Multistage ROS-Responsive and Natural Polyphenol-Driven Prodrug Hydrogels for Diabetic Wound Healing

Instant and Tough Adhesives for Rapid Gastric Perforation and Traumatic Pneumothorax Sealing

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