Biodegradable PMMA coated Zn–Mg alloy with bimodal grain structure for orthopedic applications - A promising alternative

Diaa, Alia A.; El-Mahallawy, Nahed; Shoeib, Madiha; Mouillard, Flavien; Ferté, Tom; Masson, Patrick; Carradò, Adele

doi:10.1016/j.bioactmat.2024.05.031

Bioactive Materials

2024

DOI: 10.1016/j.bioactmat.2024.05.031

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Biodegradable PMMA coated Zn–Mg alloy with bimodal grain structure for orthopedic applications - A promising alternative

Alia A. Diaa,

Nahed El-Mahallawy,

Madiha Shoeib

et al.

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Cited by 2 publications

References 64 publications

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Study on the Enhanced Degradable Rate of the Zn-0.4Li Alloys as Biodegradable Implants by Anodization

Zhong,

Zhao,

et al. 2024

Langmuir

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Biodegradable Zn-0.4Li alloys have been considered as medical implants due to their excellent mechanical properties and desirable biocompatibility. In this work, anodization was applied to modified corrosion resistance of the Zn-0.4Li alloy by forming a uniform and neat flower-like nanowire coating on the surface. After anodization for 7 min, the anodized Zn-0.4Li alloy had a yield strength of 253.6 MPa, ultimate tensile strength of 389.5 MPa, and elongation at a break of 66.0%. The corrosion rate of the Zn-0.4Li-7 min sample reached 0.5741 mm/y in the SBF, which was almost 18 times higher than that of the Zn-0.4Li alloy. The anodized Zn-0.4Li alloy exhibited higher antibacterial properties than that of the Zn-0.4Li alloy against Escherichia coli and Staphylococcus aureus. These results suggested that anodization may be an effective method to modulate the corrosion behavior of zinc alloys, which can be applied in the surface modification of biodegradable implants.

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Study on the Enhanced Degradable Rate of the Zn-0.4Li Alloys as Biodegradable Implants by Anodization

Zhong,

Zhao,

et al. 2024

Langmuir

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Mechanical Properties, Microstructure, Degradation Behavior, and Biocompatibility of Zn-0.5Ti-0.5Fe and Zn-0.5Ti-0.5Mg Guided Bone Regeneration Barrier Membranes Prepared Using a Powder Metallurgy Method

Chu,

Fu,

Liu

et al. 2024

ACS Biomater. Sci. Eng.

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Pure zinc exhibits low mechanical properties, making it unsuitable for use in guided bone regeneration (GBR) membranes. The present study focused on the preparation of Zn alloy GBR films using powder metallurgy, resulting in Zn-0.5Ti-0.5Fe and Zn-0.5Ti-0.5Mg alloy GBR films. The tensile strength of the pure Zn GBR film measured 85.9 MPa, while an elongation at break was 13.5%. In contrast, Zn-0.5Ti-0.5Fe and Zn-0.5Ti-0.5Mg alloy GBR films demonstrated significantly higher tensile strengths of 145.3 and 164.4 MPa, respectively, whereas elongations at break were 30.2% and 19.3%. The addition of Ti, Fe, and Mg substantially enhanced the mechanical properties of the zinc alloys. Corrosion analysis revealed that Zn-0.5Ti-0.5Fe and Zn-0.5Ti-0.5Mg alloy GBR membranes exhibited corrosion potentials of −1.298 and −1.316 V, respectively, with corresponding corrosion current densities of 12.11 and 13.32 μA/cm2. These values were translated to corrosion rates of 0.181 and 0.199 mm/year, indicating faster corrosion rates compared to pure Zn GBR membranes, which displayed a corrosion rate of 0.108 mm/year. Notably, both Zn-based alloy GBR membranes demonstrated excellent cytocompatibility, with a cytotoxicity rating of 0–1 in 25% leachate. Additionally, these membranes exhibited favorable osteogenic ability, as evidenced by the quantitative bone volume/tissue volume ratios (BV/TV) of new bone formation, which reached 30.3 ± 1.4% and 65.5 ± 1.8% for the Zn-0.5Ti-0.5Fe and Zn-0.5Ti-0.5Mg alloy GBR membranes, respectively, after 12 weeks of implantation. These results highlighted the significant potential for facilitating new bone growth. The proposed Zn-0.5Ti-0.5Fe and Zn-0.5Ti-0.5Mg alloy GBR membranes showed promise as viable biodegradable materials for future clinical studies.

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Biodegradable PMMA coated Zn–Mg alloy with bimodal grain structure for orthopedic applications - A promising alternative

Cited by 2 publications

References 64 publications

Study on the Enhanced Degradable Rate of the Zn-0.4Li Alloys as Biodegradable Implants by Anodization

Study on the Enhanced Degradable Rate of the Zn-0.4Li Alloys as Biodegradable Implants by Anodization

Mechanical Properties, Microstructure, Degradation Behavior, and Biocompatibility of Zn-0.5Ti-0.5Fe and Zn-0.5Ti-0.5Mg Guided Bone Regeneration Barrier Membranes Prepared Using a Powder Metallurgy Method

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