Biodegradable poly(D,L-lactide-co-glycolide)/poly(L-γ-glutamic acid) nanoparticles conjugated to folic acid for targeted delivery of doxorubicin

Jaimes-Aguirre, Laura; Morales-Ávila, Enrique; Ocampo‐García, Blanca; Medina, Luis Alberto; López-Téllez, Gustavo; Gibbens-Bandala, Brenda; Izquierdo-Sánchez, Vanessa

doi:10.1016/j.msec.2017.03.145

Cited by 45 publications

(23 citation statements)

References 56 publications

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“…Poly(γ-glutamic acid) (γ-PGA), a natural biopolymer that is water-soluble, non-toxic, edible and biodegradable 21,22 has shown potential in tissue engineering. The structure of the polymer containing a large number of carboxyl groups 23 can load drugs 21 and has strong hydrophilicity, 24 so it can improve the hydrophobicity and SOD loading of the hydrogels. Zhuang et al 25 prepared a poly(γ-glutamic acid)-based hydrogel loaded with superoxide dismutase (SOD) to accelerate wound healing.…”

Section: Introductionmentioning

confidence: 99%

<p>Poly(N-Isopropyl-Acrylamide)/Poly(γ-Glutamic Acid) Thermo-Sensitive Hydrogels Loaded with Superoxide Dismutase for Wound Dressing Application</p>

Dong¹,

Zhuang²,

Hao³

et al. 2020

IJN

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Introduction: Chronic trauma repair is an important issue affecting people's healthy lives. Thermo-sensitive hydrogel is injectable in situ and can be used to treat large-area wounds. In addition, antioxidants play important roles in promoting wound repair. Methods: The purpose of this research was to prepare a novel thermo-sensitive hydrogelpoly(N-isopropyl-acrylamide)/poly(γ-glutamic acid) (PP) loaded with superoxide dismutase (SOD) to improve the effect for trauma treatment. The micromorphology of the hydrogel was observed by scanning electron microscope and the physical properties were measured. The biocompatibility of hydrogel was evaluated by MTT experiment, and the effect of hydrogel on skin wound healing was evaluated by in vivo histological staining. Results: Gelling behavior and differential scanning calorimeter outcomes showed that the PP hydrogels possessed thermo-sensitivity at physiological temperature and the phase transformation temperature was 28.2°C. The high swelling rate and good water retention were conducive to wound healing. The activity of SOD in vitro was up to 85% at 10 h, which was advantageous to eliminate the superoxide anion. MTT assay revealed that this hydrogel possessed good biocompatibility. Dressings of PP loaded with SOD (SOD-PP) had a higher wound closure rate than other treatments in vivo in diabetic rat model. Discussion: The SOD-PP thermo-sensitive hydrogels can effectively promote wound healing and have good application prospects for wound repair.

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Section: Introductionmentioning

confidence: 99%

<p>Poly(N-Isopropyl-Acrylamide)/Poly(γ-Glutamic Acid) Thermo-Sensitive Hydrogels Loaded with Superoxide Dismutase for Wound Dressing Application</p>

Dong¹,

Zhuang²,

Hao³

et al. 2020

IJN

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“…Many studies have focused on the biodegradable polymers over recent decades because of their large potential applications in the field of food packaging, biomedical and pharmaceutical use, agricultural films, and single‐use disposable items . Development of consumer products from biodegradable and renewable materials is currently an area of great interest for researchers.…”

Section: Introductionmentioning

confidence: 99%

Improvement of compatibility and mechanical properties of the poly(lactic acid)/poly(butylene adipate‐co‐terephthalate) blends and films by reactive extrusion with chain extender

Yan

Yang

et al. 2017

Polymer Engineering & Sci

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Biodegradable poly(lactic acid)/poly(butylene adipate‐co‐terephthalate) (PLA/PBAT) blends and films were prepared by melt blending and blowing films technique in the presence of chain extender. The Joncryl ADR‐4370F (ADR) was used as the chain extender. The effect of ADR on the mechanical properties, rheological behavior, morphology, and thermal behavior of PLA/PBAT blends was investigated. The mechanical properties were markedly improved by incorporation of 0.15 phr ADR, for example, the elongation at break increased from 23.5% to 410.3% and the notched Izod impact strength increased from 7.5 to 33.4 KJ/m2 for the PLA/PBAT/ADR blends. The elongation at break increased from 17.7% to 264.6% and the tensile strength increased from 28.0 to 40.7 MPa for the PLA/PBAT/ADR films in the transverse direction. The tensile strength and tear strength of the films increased from 28.0 to 40.7 MPa and from 135.5 to 163.8 kN/m in the machine direction, respectively. Morphological observation through scanning electron microscopy revealed that the compatibility of the PLA/PBAT blends was greatly enhanced by the incorporation of ADR. The interfacial adhesion was improved between PLA phase and PBAT phase. These findings contributed new knowledge to the additives area and gave important implications for manufacturing biodegradable polymer packaging material. POLYM. ENG. SCI., 58:1868–1878, 2018. © 2017 Society of Plastics Engineers

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“…Additionally, particles with a higher size are easily recognized by the mononuclear phagocyte system, as they are removed from the body before they can perform their designed therapeutic function [ 36 ]. In this sense, it is desirable that nanoparticles aimed to be used as drug delivery systems present a size lower than 600 nm [ 37 , 38 ].…”

Section: Resultsmentioning

confidence: 99%

Cashew Gum Polysaccharide Nanoparticles Grafted with Polypropylene Glycol as Carriers for Diclofenac Sodium

et al. 2021

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This investigation focuses on the development and optimization of cashew gum polysaccharide (CGP) nanoparticles grafted with polypropylene glycol (PPG) as carriers for diclofenac sodium. The optimization of parameters affecting nanoparticles formulation was performed using a central composite rotatable design (CCRD). It was demonstrated that the best formulation was achieved when 10 mg of CGP was mixed with 10 μL of PPG and homogenized at 22,000 rpm for 15 min. The physicochemical characterization evidenced that diclofenac was efficiently entrapped, as increases in the thermal stability of the drug were observed. The CGP-PPG@diclofenac nanoparticles showed a globular shape, with smooth surfaces, a hydrodynamic diameter around 275 nm, a polydispersity index (PDI) of 0.342, and a zeta potential of −5.98 mV. The kinetic studies evidenced that diclofenac release followed an anomalous transport mechanism, with a sustained release up to 68 h. These results indicated that CGP-PPG nanoparticles are an effective material for the loading/release of drugs with similar structures to diclofenac sodium.

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Biodegradable poly(D,L-lactide-co-glycolide)/poly(L-γ-glutamic acid) nanoparticles conjugated to folic acid for targeted delivery of doxorubicin

Cited by 45 publications

References 56 publications

<p>Poly(N-Isopropyl-Acrylamide)/Poly(γ-Glutamic Acid) Thermo-Sensitive Hydrogels Loaded with Superoxide Dismutase for Wound Dressing Application</p>

<p>Poly(N-Isopropyl-Acrylamide)/Poly(γ-Glutamic Acid) Thermo-Sensitive Hydrogels Loaded with Superoxide Dismutase for Wound Dressing Application</p>

Improvement of compatibility and mechanical properties of the poly(lactic acid)/poly(butylene adipate‐co‐terephthalate) blends and films by reactive extrusion with chain extender

Cashew Gum Polysaccharide Nanoparticles Grafted with Polypropylene Glycol as Carriers for Diclofenac Sodium

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