Biodegradable poly(L‐lactide) and polycaprolactone block copolymer networks

Abstract

New biodegradable block copolymer networks were synthesized from methacrylate‐terminated poly(L‐lactide) (mLA) and polycaprolactone (mCL) macromers. This allowed the realization of a series of materials in which the macromer ratio can be used to tailor the physical and mechanical properties of the materials. The synthesis of the macromers was characterized using Fourier transform infrared (FTIR) spectroscopy and 1H NMR spectroscopy. Poly(mCL) and poly(mLA) networks were prepared by photopolymerization of the macromers, and copolymers were also prepared from the two macromers in various proportions. The phase microstructure of the new systems and the network architecture were investigated using differential scanning calorimetry, FTIR spectroscopy, dynamic mechanical analysis and thermogravimetry studies. Copyright © 2010 Society of Chemical Industry

Synthesis and properties of caprolactone and ethylene glycol copolymers for neural regeneration

“…Polyesters like poly lactic acid (PLLA), poly glycolic acid (PGA) and their copolymers poly(lactic-co-glycolic acid) (PLGA) were one of the first polymers used because of their biodegradability through hydrolytic mechanisms, availability, and their ease of processing [8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24]. Hadlock et al [25] made a PLLA foam conduit materials seeded with Schwann cells to promote guide regeneration in the peripheral nerve.…”