Biodegradable Polycaprolactone Nanoparticles Based Drug Delivery Systems: A Short Review

Abstract

Nanoparticles based drug delivery systems showing greater potential in various biomedical applications to deliver the drugs/bioactive molecules in controlled manner to the targeted site. Polycaprolactone, biodegradable polyester, owing its tailorable properties, various forms of polycaprolactone are used as drug carrier for a range of biomedical applications. Nanoprecipitation is a simple method to prepare the polycaprolactone nanoparticles to improve the bioavailability and therapeutic potential of various drugs/bioactive molecules. This short review focused on the preparation of polycaprolactone nanoparticles using nanoprecipitation method, nanoparticles-drug formulations and its use in various drug delivery applications.

Amphotericin B Loaded Polymeric Nanoparticles for Treatment of Leishmania Infections

“…The mechanism of Amp B release and the kinetics order of drug release from the polymeric nanoparticles were studied by fitting the in vitro drug release data of the formulation at different pH into different kinetic models, which were the zero-order, first-order, Higuchi and Korsmeyer–Peppas models [ 13 ]. Zero-order release kinetics describe systems where the drug release rate is constant over a period of time and independent of the concentration of drug in the polymeric system (Equation (1)) [ 28 ]: where M t is the absolute cumulative amount of drug released at time t , M ∞ is the absolute cumulative amount of drug released at infinite time and k is the constant of the considered system.…”

“…In consideration of such challenges, the design and development of drug delivery systems based on the blending of PCL with other polymers or its copolymers can be considered in principle to improve the control release of drugs at various pH levels and to tune the permeability of PCL for achieving a desirable delivery [27]. The mechanism of Amp B release and the kinetics order of drug release from the polymeric nanoparticles were studied by fitting the in vitro drug release data of the formulation at different pH into different kinetic models, which were the zero-order, first-order, Higuchi and Korsmeyer-Peppas models [13]. Zero-order release kinetics describe systems where the drug release rate is constant over a period of time and independent of the concentration of drug in the polymeric system (Equation 1) [28]:…”

“…The Higuchi model describes the release of a drug from porous matrices as the square root of the time dependent process, based on Fickian diffusion [29]. It was derived under pseudo-steady state assumptions and it is given in its simplest form as: The mechanism of Amp B release and the kinetics order of drug release from the polymeric nanoparticles were studied by fitting the in vitro drug release data of the formulation at different pH into different kinetic models, which were the zero-order, first-order, Higuchi and Korsmeyer-Peppas models [13]. Zero-order release kinetics describe systems where the drug release rate is constant over a period of time and independent of the concentration of drug in the polymeric system (Equation (1)) [28]:…”

“…Furthermore, to the best of our knowledge, Amp B nanoparticles have not previously been formulated and explored in detail using polycaprolactone (PCL) as the only ingredient. Polycaprolactone is a biodegradable polymer used for the delivery of various active moieties through different routes and especially for topical drug delivery [13][14][15]. This approach is able to eliminate the use of relatively scarce and costly ingredients, overcoming economic issues.…”

Development and Evaluation of Alginate Membranes with Curcumin-Loaded Nanoparticles for Potential Wound-Healing Applications

“…Despite the CNp zeta potential value not being in this range, it should be considered that Pluronic ® F-68 was added as a stabilizer of nanoparticles, which provides them with stability by means of a repulsion effect through a steric mechanism [24]. Likewise, CNp possesses a negative charge, which is related to the carboxylic end group of PCL [25]; thus, negatively charged nanoparticles could permeate adequately in conjunction with the negative charges existing on the skin [26].…”