Biodegradable polyester-based nano drug delivery system in cancer chemotherapy: a review of recent progress (2021–2023)

Abstract

Cancer presents a formidable threat to human health, with the majority of cases currently lacking a complete cure. Frequently, chemotherapy drugs are required to impede its progression. However, these drugs frequently suffer from drawbacks such as poor selectivity, limited water solubility, low bioavailability, and a propensity for causing organ toxicity. Consequently, a concerted effort has been made to seek improved drug delivery systems. Nano-drug delivery systems based on biodegradable polyesters have emerged as a subject of widespread interest in this pursuit. Extensive research has demonstrated their potential for offering high bioavailability, effective encapsulation, controlled release, and minimal toxicity. Notably, poly (ε-caprolactone) (PCL), poly (lactic-co-glycolic acid) (PLGA), and polylactic acid (PLA) have gained prominence as the most widely utilized options as carriers of the nano drug delivery system. This paper comprehensively reviews recent research on these materials as nano-carriers for delivering chemotherapeutic drugs, summarizing their latest advancements, acknowledging their limitations, and forecasting future research directions.

Biotinylated Theranostic Amphiphilic Polyurethane for Targeted Drug Delivery

“…Thus, the synthesized enzyme and H 2 S degradable self-assembled polyurethane can be considered as an excellent theranostic drug delivery system (DDS) with cancer cell targeting ability. Such endogenous stimuli triggered main chain degradable DDS resolves the issues of unwanted organ accumulation of nanocarriers along with clearance from blood circulation …”

“…Such endogenous stimuli triggered main chain degradable DDS resolves the issues of unwanted organ accumulation of nanocarriers along with clearance from blood circulation. 60 ■ ASSOCIATED CONTENT * sı Supporting Information…”

Macrophage membrane-coated nanoparticles for the treatment of infectious diseases

“…On the other hand, cell membranes serve as shells to protect nanomedicines from rapid degradation in complex biological environments to prolong their blood circulation time [73,74]. In addition, systemically administered bare nanoparticles are recognized as foreign elements that are quickly cleared by the immune system or phagocytosed by the reticuloendothelial system [75,76]. Although polyethylene glycol (PEG) modification significantly reduces the probability of phagocytosis of nanoparticles by phagocytes, anti-PEG immunoglobulin M (IgM) is generated after the first injection of PEGylated nanoparticles and is quickly cleared [77].…”

A Review of Recent Developments in Biopolymer Nano-Based Drug Delivery Systems with Antioxidative Properties: Insights into the Last Five Years

“…For these purposes, the mainly used biopolymers are polysaccharides (chitosan, alginate, cellulose, starch, hyaluronic acid, dextran), polynucleotides, polyesters (polylactide, poly(lactide-co-glycolide), polycaprolactone, etc. ), and proteins (silk fibroin, collagen, gelatine, and albumin) [33,[38][39][40][41][42][43]. Proteins are biopolymers made up of amino acid monomers linked by peptide bonds [44].…”