Biodegradable polyester/modified mesoporous silica composites for effective bone repair with self‐reinforced properties

Abstract

A series novel composites based on poly(L‐lactide) (PLLA) oligomer modified mesoporous silica (MCM41) homogeneous dispersed into poly(L‐lactide‐co‐trimethylene carbonate‐co‐glycolide) (PLTG) terpolymer has been successfully prepared. The structure of PLTG terpolymer was characterized by 1H NMR. The structure and properties of modified and unmodified MCM41 were attested by Fourier transform infrared spectroscopy (FTIR), thermogravimetric analyzer (TGA), X‐ray diffraction (XRD), N2 adsorption–desorption, scanning electron microscope (SEM), and transmission electron microscope (TEM), which demonstrated that the MCM41 was successfully grafted by the PLLA oligomer. The effect of different concentration of modified MCM41 in PLTG matrix on thermal properties, mechanical properties, and hydrophilicity was investigated by TGA, differential scanning calorimetry (DSC), mechanical testing, contact angle measurement, and SEM. The results of mechanical tests showed that 5 wt% of modified MCM41 nanoparticles gave rise to optimal reinforcing effect. The tensile strength, Young's modulus, and elongation at break of the PLTG/PLLA‐MCM41 (5%) composites were 33.2 Mpa, 1.58 Gpa, and 268.7%, respectively, which were all higher than the PLTG/MCM41 (5%) composites and pristine PLTG matrix, which were due to good interfacial adhesion between the PLTG matrix and MCM41 nanoparticles. TGA and DSC have shown that 5% modified MCM41 in the PLTG increased the temperature of composite degradation and Tg. Water contact angle measurement showed the hydrophilicity of the composites increases with the increase of modified MCM41 content. The live/dead assay showed that the modified MCM41 existing on the PLTG matrix presents very excellent cytocompatibility. Therefore, the novel composite material represents promising way for bone tissue engineering application.

Multi-Responsive Nanocarriers Based on β-CD-PNIPAM Star Polymer Coated MSN-SS-Fc Composite Particles

“…The TGA curves of MSNs, MSN-SH, MSN-SS-NH2, and MSN-SS-Fc are shown in Figure 3B, clearly indicating the successful modification of the nanoparticles. The initial weight loss of all samples from 50 to 100 °C was due to the physically adsorbed water [24]. Compared to the weight loss of the blank MSNs, the additional weight loss of about 8.72% for MSN-SH was assigned to the removal of the organosilane portion.…”

Mesoporous Silica Based Nanostructures for Bone Tissue Regeneration

“…A notable amount of mineralization with a bone shell formation surrounding the bone marrow cavity was observed upon treatment with (G3) confirming the superior osteogenic potential of the dual bioactive factor loaded porous nanofibrous scaffolds. Wang et al (2019) reported the synthesis of poly (L-lactide) (PLLA) oligomer based novel biodegradable polyester modified MSNs for bone tissue repair. Initially, a PLLA-TMC-GA terpolymer (PLTG) was synthesized by ring-opening polymerization at 130°C for 72 h using L-lactide (LLA)/ trimethylene carbonate (TMC)/glycolide (GA) at a ratio of 90:5:5 in the presence of Sn (Oct) 2 as a catalyst.…”

Mesoporous silica nanoparticles for tissue‐engineering applications

“…Similarly, the mechanical property and micropore size of photo‐crosslinked gelatin hydrogel scaffold was also altered by blending MSNs in the preparation process (Wang et al, ). Other types of scaffolds, such as electrospun nanofibers (Mehrasa et al, ; Mehrasa, Asadollahi, Ghaedi, Salehi, & Arpanaei, ; Qiu et al, ), polymer scaffolds (Wang et al, ), elastomers (Li, Guo, Ge, Ma, & Lei, ), and even the 3D‐printed scaffolds (Baumann et al, ; Zhu, Li, Zhu, Zhang, & Ye, ), have also been reported with altered mechanical properties, structures,, or cell–scaffold interactions after doping of MSNs. Besides, MSNs could even regulate the degradation rate of a scaffold.…”