Biodegradable Polymer Iron Oxide Nanocomposites: the Future of Biocompatible Magnetism

Meyer, Randall A.; Green, Jordan J.

doi:10.2217/nnm.15.165

Cited by 12 publications

(10 citation statements)

References 22 publications

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“…Previous studies in other labs and our lab have demonstrated the genotoxic potential of pristine iron oxide ENMs (Alarifi et al , 2014; Watson, et al, 2013). The biocompatibility and utility of nanocomposites containing iron oxide is described in various studies (Meyer and Green, 2015). Our observations suggest an enhancement of genotoxicological properties of released particles from thermally decomposed iron containing nanocomposites indicating a potential environmental health and safety concern.…”

Section: 0 Discussionmentioning

confidence: 99%

Toxicological implications of released particulate matter during thermal decomposition of nano-enabled thermoplastics

Watson-Wright¹,

Singh²,

Demokritou³

2017

NanoImpact

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Nano-enabled thermoplastics are part of the growing market of nano-enabled products (NEPs) that have vast utility in several industries and consumer goods. The use and disposal of NEPs at their end of life has raised concerns about the potential release of constituent engineered nanomaterials (ENMs) during thermal decomposition and their impact on environmental health and safety. To investigate this issue, industrially relevant nano-enabled thermoplastics including polyurethane, polycarbonate, and polypropylene containing carbon nanotubes (0.1 and 3% w/v, respectively), polyethylene containing nanoscale iron oxide (5% w/v), and ethylene vinyl acetate containing nanoscale titania (2 and 5% w/v) along with their pure thermoplastic matrices were thermally decomposed using the recently developed lab based Integrated Exposure Generation System (INEXS). The life cycle released particulate matter (called LCPM) was monitored using real time instrumentation, size fractionated, sampled, extracted and prepared for toxicological analysis using primary small airway epithelial cells to assess potential toxicological effects. Various cellular assays were used to assess reactive oxygen species and total glutathione as measurements of oxidative stress along with mitochondrial function, cellular viability, and DNA damage. By comparing toxicological profiles of LCPM released from polymer only (control) with nano-enabled LCPM, potential nanofiller effects due to the use of ENMs were determined. We observed associations between NEP properties such as the percent nanofiller loading, host matrix, and nanofiller chemical composition and the physico-chemical properties of released LCPM, which were linked to biological outcomes. More specifically, an increase in percent nanofiller loading promoted a toxicological response independent of increasing LCPM dose. Importantly, differences in host matrix and nanofiller composition were shown to enhance biological activity and toxicity of LCPM. This work highlights the importance of assessing the toxicological properties of LCPM and raises environmental health and safety concerns of nano-enabled products at their end of life during thermal decomposition/incineration.

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Section: 0 Discussionmentioning

confidence: 99%

Toxicological implications of released particulate matter during thermal decomposition of nano-enabled thermoplastics

Watson-Wright¹,

Singh²,

Demokritou³

2017

NanoImpact

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“…They are preferred for use in biomedicine as they are biocompatible and potentially non-toxic to humans [ 46 ]. Iron oxide is easily degradable and can therefore be useful when used for in vivo applications [ 49 ] such as cancer magnetic therapy [ 50 , 51 ]. Here the iron oxide nanoparticles are loaded with antitumor drugs and remotely directed via an external magnetic field.…”

Section: Introductionmentioning

confidence: 99%

Green synthesis as a simple and rapid route to protein modified magnetic nanoparticles for use in the development of a fluorometric molecularly imprinted polymer-based assay for detection of myoglobin

et al. 2020

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“…This article presents a novel approach to heal large damage by dispersing magnetite (Fe3O4) within an elastomeric thermoreversible covalent network based on the DA chemistry. Magnetic nanoparticles of iron oxides have been intensively studied as a result of their technological applications, pointing out data storage [27], biosensors [28], drug delivery [29], wastewater treatment [30], materials science [31] and catalysis [32,33], among others. Incorporation of magnetic particles within self-healing materials has received research attention for different applications.…”

Section: Introductionmentioning

confidence: 99%

A novel approach for the closure of large damage in self-healing elastomers using magnetic particles

Cerdan

Assche

Puyvelde

et al. 2020

Polymer

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Biodegradable Polymer Iron Oxide Nanocomposites: the Future of Biocompatible Magnetism

Cited by 12 publications

References 22 publications

Toxicological implications of released particulate matter during thermal decomposition of nano-enabled thermoplastics

Toxicological implications of released particulate matter during thermal decomposition of nano-enabled thermoplastics

Green synthesis as a simple and rapid route to protein modified magnetic nanoparticles for use in the development of a fluorometric molecularly imprinted polymer-based assay for detection of myoglobin

A novel approach for the closure of large damage in self-healing elastomers using magnetic particles

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