Biodegradable polymeric occluder for closure of atrial septal defect with interventional treatment of cardiovascular disease

Li, Boning; Xie, Zhaofeng; Wang, Qunsong; Chen, Xianmiao; Liu, Qingsong; Wang, Wei; Shen, Yang; Li, Anning; Li, Yifan; Gui, Zhilun; Liu, Jianxiong; Zhang, Deyuan; Liu, Cong; Wang, Shushui; Xie, Yumei; Zhang, Zhiwei; Ding, Jiandong

doi:10.1016/j.biomaterials.2021.120851

Cited by 46 publications

(39 citation statements)

References 69 publications

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“…Properties of interfaces and surfaces of implanted biomaterials, such as biochemical composition, ligand organization, stiffness, viscoelasticity, topology, and even nanoscale cues, have been proved effective for triggering cell responses. − Among these, RGD (Arg–Gly–Asp) peptides can enhance cell–substrate interactions and can also regulate cell behaviors like adhesion, migration, proliferation, differentiation, dedifferentiation, etc. − In the present work, RGD peptides were used for surface modification to explore whether its nanospacing can regulate relative cell migration speeds among different cell types. ECs and SMCs were chosen as representative cell types.…”

Section: Introductionmentioning

confidence: 99%

Enlargement, Reduction, and Even Reversal of Relative Migration Speeds of Endothelial and Smooth Muscle Cells on Biomaterials Simply by Adjusting RGD Nanospacing

Liu

Zheng

et al. 2021

ACS Appl. Mater. Interfaces

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Although many tissue regeneration processes after biomaterial implantation are related to migrations of multiple cell types on material surfaces, available tools to adjust relative migration speeds are very limited. Herein, we put forward a nanomaterial strategy to employ surface modification with arginine–glycine–aspartate (RGD) nanoarrays to tune in vitro cell migration using endothelial cells (ECs) and smooth muscle cells (SMCs) as demonstrated cell types. We found that migrations of both cell types exhibited a nonmonotonic trend with the increase of RGD nanospacing, yet with different peaks74 nm for SMCs but 95 nm for ECs. The varied sensitivities afford a facile way to regulate the relative migration speeds. Although ECs migrated at a speed similar to SMCs on a non-nano surface, the migration of ECs could be controlled to be significantly faster or slower than SMCs simply by adjusting the RGD nanospacing. This study suggests a potential application of surface modification of biomaterials on a nanoscale level.

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Section: Introductionmentioning

confidence: 99%

Enlargement, Reduction, and Even Reversal of Relative Migration Speeds of Endothelial and Smooth Muscle Cells on Biomaterials Simply by Adjusting RGD Nanospacing

Liu

Zheng

et al. 2021

ACS Appl. Mater. Interfaces

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“…These additional treatments to accelerate polymer dissolution work well in labs, yet are unsuitable in many situations such as in hospitals where there is an instant demand. While much progress has been made in the fields of polymers and biomaterials, 45–52 the instant dissolution of a biomedical polymer in water has rarely been achieved. So far, no theory has been provided for the rapid dissolution of polymers without using additional treatments.…”

Section: Discussionmentioning

confidence: 99%

A coordination strategy to achieve instant dissolution of a biomedical polymer in water via manual shaking

et al. 2022

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“…Polymer science and biomedical materials have recently seen great progress. [18][19][20][21][22][23] Here, we suggest a strategy for an intelligent paper-free sprayable skin mask schematically presented in Figure 1A. The material containing the substance is in the solution state before use.…”

Section: Introductionmentioning

confidence: 99%

Intelligent Paper‐Free Sprayable Skin Mask Based on an In Situ Formed Janus Hydrogel of an Environmentally Friendly Polymer

Cai

Tang

Zhang

et al. 2022

Adv Healthcare Materials

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Traditional skin care masks usually use a piece of paper to hold the aqueous essences, which are not environmentally friendly and not easy to use. While a paper-free mask is desired, it is faced with a dilemma of moisture holding and rapid release of encapsulated bioactive substances. Herein, a paper-free sprayable skin mask is designed from an intelligent material-a thermogel which undergoes sol-gel-suspension transitions upon heating-to solve this dilemma. A synthesized block copolymer of poly(ethylene glycol) and poly(lactide-co-glycolide) with appropriate ratios can be dissolved in water, and thus easily mixed with a biological substance. The mixture is sprayable. After spraying, a Janus film is formed in situ with a physical gel on the outside and a suspension on the inside facing skin. Thus, both moisture holding and rapid release are achieved. Such a thermogel composed of biodegradable amphiphilic block copolymers loaded with nicotinamide as a skin mask is verified to reduce pigmentation on a 3D pigmented reconstructed epidermis model and further in a clinical study. This work might be stimulating for investigations and applications of biodegradable and intelligent soft matter in the fields of drug delivery and regenerative medicine.

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Biodegradable polymeric occluder for closure of atrial septal defect with interventional treatment of cardiovascular disease

Cited by 46 publications

References 69 publications

Enlargement, Reduction, and Even Reversal of Relative Migration Speeds of Endothelial and Smooth Muscle Cells on Biomaterials Simply by Adjusting RGD Nanospacing

Enlargement, Reduction, and Even Reversal of Relative Migration Speeds of Endothelial and Smooth Muscle Cells on Biomaterials Simply by Adjusting RGD Nanospacing

A coordination strategy to achieve instant dissolution of a biomedical polymer in water via manual shaking

Intelligent Paper‐Free Sprayable Skin Mask Based on an In Situ Formed Janus Hydrogel of an Environmentally Friendly Polymer

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