Biodegradable polymeric wires: monofilament and multifilament

Silva, Milena Costa da; Silva, Henrique Nunes da; Holanda, Samuell Aquino; Silva, Alan Roger Oliveira; Fook, Marcus Vinícius Lia

doi:10.1080/14328917.2019.1622256

Cited by 5 publications

(6 citation statements)

References 33 publications

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“…Torsion of the CS filaments contributes to formed pores in the structure of threads, leading to uneven load distribution through the thread cross-section, causing a reduction in tensile strength [ 28 , 29 ]. This effect was also observed in our study previously reported [ 23 ].…”

Section: Resultssupporting

confidence: 92%

“…CS solution (4% w / v ) was prepared as previously reported [ 22 , 23 , 24 ]. In short, CS was dissolved in a lactic acid aqueous solution (0.206 mol/L), in stoichiometric relationship with CS amine groups, at constant stirring (200 rpm) at 25 ± 1 °C for 2 h. The obtained CS solution was transferred to a syringe (20 mL capacity and 1 mm diameter outlet tip) for subsequent wet spinning.…”

Section: Methodsmentioning

confidence: 99%

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Chitosan Woven Meshes: Influence of Threads Configuration on Mechanical, Morphological, and Physiological Properties

Silva

Santos

et al. 2020

Polymers

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This study aimed to develop meshes from the weaving of mono- and multifilament wet-spun chitosan (CS), for possible biomedical applications. In the wet-spinning process, CS solution (4% w/v) was extruded in a coagulation bath containing 70% sodium hydroxide solution (0.5 M), and 30% methanol was used. The multifilament thread was prepared by twisted of two and three monofilaments. CS threads obtained were characterized by tensile tests and scanning electron microscopy (SEM). Moreover, it was verified from the morphological tests that threads preserve the characteristics of the individual filaments and present typical “skin-core” microstructure obtained by wet spinning. CS woven meshes obtained were evaluated by optical microscopy (OM), tensile test, swelling degree, and in vitro enzymatic biodegradation. Mechanical properties, biodegradation rate, and amount of fluid absorbed of CS woven meshes were influenced by thread configuration. Hydrated CS meshes showed a larger elastic zone than the dry state. Therefore, CS woven meshes were obtained with modular properties from thread configuration used in weaving, suggesting potential applications in the biomedical field, like dressings, controlled drug delivery systems, or mechanical support.

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Section: Resultssupporting

confidence: 92%

Section: Methodsmentioning

confidence: 99%

Chitosan Woven Meshes: Influence of Threads Configuration on Mechanical, Morphological, and Physiological Properties

Silva

Santos

et al. 2020

Polymers

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“…A study that evaluated the surface of a chitosan thread by electron microscopy confirmed the possibility of producing a compact monofilament with a smooth surface, absence of porosity, and cylindrical shape. 15 The results obtained here are in agreement with those observed by other authors, who stated that the monofilament thread does not have capillarity, which limits the drainage of luminal fluid into the abdominal cavity, reduces the formation of biofilm and bacterial proliferation, and generates a low coefficient of friction, facilitating the passage between tissues, minimizing tissue trauma, and, consequently, reducing tissue reaction. 40 The proliferative phase is assumed to be one of the most important in cases of intestinal repair, given that a rapid and logarithmic increase in the tensile strength of intestinal wounds was observed in this period.…”

Section: Notesupporting

confidence: 92%

“…The material has the advantages of monofilament production, smooth surface, and hydrolysis absorption. [8][9][10][11][12][13][14][15] Chitosan suture thread is also expected to replicate hemostatic, 16 antiadherent, 17 and angiogenic potentials, stimulate fibroplasia 18 and proliferation of granulation tissue, 19 and promote the chemotaxis of macrophages 20 and fibroblasts, 21 actions evidenced with other biomaterials based on this organic polymer. [16][17][18][19][20][21] However, this suture thread was submitted to animal experimentation and evaluation of its effects on tissue repair on only three occasions.…”

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confidence: 99%

Chitosan thread in the healing of the cecal wall of rabbits (Oryctolagus cuniculus) submitted to cecorrhaphy

Filho¹,

Moura

Queiroz

et al. 2023

J Biomed Mater Res

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The development and evaluation of synthesis materials are crucial to reducing the morbidity and magnitude of post‐enterorrhaphy surgical complications. Despite the possibility of production, chitosan thread has not yet been used in enterorrhaphy, and its effects on intestinal healing have not been evaluated. Therefore, this study aimed to evaluate the effects of chitosan thread on the intestinal wall repair of rabbits submitted to cecorrhaphy. For this, 42 rabbits were allocated into two groups with 21 animals. One group was submitted to cecorrhaphy with chitosan suture thread (CG) and the other with poliglecaprone suture thread (PG). The occurrence of postoperative complications, the intensity of edema, cellular response, formation of granulation tissue, as well as the deposition and maturation of collagen fibers, and the intensity of vascular endothelial growth factor (VEGF‐α) expression, were evaluated during the intestinal wall repair process. The evaluations occurred on the 5th, 15th, and 25th postoperative (PO) days. The animals did not develop peritonitis, but adherence was observed in six animals from CG and seven from PG, with no difference between groups. The polymorphonuclear infiltrate showed higher intensity and higher amount of type III collagen fibers in CG on the 15th PO day. In contrast, a lower amount of type I collagen fibers was observed in CG samples on the 25th PO day. Therefore, the chitosan thread used for cecorrhaphy in rabbits results in minimal postoperative complications, presents biocompatibility, and bioactively assists the tissue repair process of the cecal wall, inducing minimal tissue reaction, stimulating the deposition of type III collagen fibers in the proliferative phase, with sustained VEGF‐α expression, but with reduced deposition of type I fibers, indicating a delay in collagen maturation.

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“…A large number of coagulation systems like 1M sodium hydroxide (NaOH) [ 13 ], a mixture of 10% solutions of NaOH and ethanol (EtOH) [ 14 ], NaOH–sodium sulfate [ 15 ], NaOH–methanol, and calcium chloride or calcium acetate saturated water-methanol [ 16 ] have been evaluated in combination with different solvents such as acetic acid [ 12 , 17 ], lactic acid [ 18 ], formic acid [ 19 ], and glycine chloride [ 3 ] to prepare wet spun chitosan fibers. The crosslinking of chitosan fibers is usually performed to improve the mechanical properties of the fibers [ 20 ].…”

Section: Introductionmentioning

confidence: 99%

New Solvent and Coagulating Agent for Development of Chitosan Fibers by Wet Spinning

et al. 2021

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Adipic acid was evaluated as a novel solvent for wet spinning of chitosan fibers. A solvent with two carboxyl groups could act as a physical crosslinker between the chitosan chains, resulting in improved properties of the fibers. The performance of adipic acid was compared with conventional solvents, i.e., lactic, citric, and acetic acids. Chitosan solutions were injected into a coagulation bath to form monofilaments. Sodium hydroxide (NaOH) and its mixture with ethanol (EtOH) were used as coagulation agents. Scanning electron microscopy confirmed the formation of uniform chitosan monofilaments with an even surface when using adipic acid as solvent. These monofilaments generally showed higher mechanical strength compared to that of monofilaments produced using conventional solvents. The highest Young’s modulus, 4.45 GPa, was recorded for adipic acid monofilaments coagulated in NaOH-EtOH. This monofilament also had a high tensile strength of 147.9 MPa. Furthermore, taking advantage of chitosan insolubility in sulfuric acid (H2SO4) at room temperature, chitosan fibers were successfully formed upon coagulation in H2SO4-EtOH. The dewatering of fibers using EtOH before drying resulted in a larger fiber diameter and lower mechanical strength. Adipic acid fibers made without dehydration illustrated 18% (for NaOH), 46% (for NaOH-EtOH), and 91% (for H2SO4-EtOH) higher tensile strength compared to those made with dehydration.

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Biodegradable polymeric wires: monofilament and multifilament

Cited by 5 publications

References 33 publications

Chitosan Woven Meshes: Influence of Threads Configuration on Mechanical, Morphological, and Physiological Properties

Chitosan Woven Meshes: Influence of Threads Configuration on Mechanical, Morphological, and Physiological Properties

Chitosan thread in the healing of the cecal wall of rabbits (Oryctolagus cuniculus) submitted to cecorrhaphy

New Solvent and Coagulating Agent for Development of Chitosan Fibers by Wet Spinning

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