Biodegradable polymers: Which, when and why?

Kotwal, VB; Saifee, Maria; Inamdar, Nazma; Bhise, Kiran

doi:10.4103/0250-474x.38465

Cited by 17 publications

(2 citation statements)

References 60 publications

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“…As CS has a pKa of 5.3-6 and vinorelbine tartarate has a pKa of 4, the rise in the concentration of vinorelbine tartarate reduced the ionization of CS. 2,25,32 The burst release of Vinorelbine tartarate for PEC 1:3 Polyelectrolytic complexes are due to less-than-ideal NH 3 -COO ionic interaction, larger percentage (w/w) of CS results in increased degree of swelling in acidic conditions. With increase in GKG (5 w/w) concentration in the Polyelectrolytic complexes, GKG is a hydrophilic polymer and can facilitate the entry of solution into the particles, generating maximum swelling, vinorelbine tartarate was found to be enhanced.…”

Section: Parameters (Units) Valuesmentioning

confidence: 99%

The Development, Formulation, and Assessment of Polyelectrolytic Complexes of an Anticancer Compound (Vinorelbine Tartarate)

Mohsen,

Nagasree,

Patil

2024

Ind. J. Pharm. Edu. Res

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Section: Parameters (Units) Valuesmentioning

confidence: 99%

The Development, Formulation, and Assessment of Polyelectrolytic Complexes of an Anticancer Compound (Vinorelbine Tartarate)

Mohsen,

Nagasree,

Patil

2024

Ind. J. Pharm. Edu. Res

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“…Smart polymers have been utilized in a pharmaceutical formulation of many drug delivery systems due to their biodegradability, biocompatibility, ease of application, site-specific drug delivery actions and extended release mechanisms. These polymers may be either natural, such as alginate, dextran, cellulose, chitosan, and lipids, or synthetic such as poly(amides), poly(amino acids), poly (anhydrides), poly(cyanoacrylates), polyesters, poly(ε-caprolactone) (PCL), poly(glycolic acids), and poly(lactic acids) 7,8. Some smart polymers have been investigated in recent years, but most of the marketed ISG products are based on poly(lactic acid) and poly(lactic-co-glycolic acid) (PLGA) 9.…”

Section: Introductionmentioning

confidence: 99%

<p>An Optimized Surfactant-Based PEG-PLCL In Situ Gel Formulation For Enhanced Activity Of Rosuvastatin In Poloxamer-Induced Hyperlipidemic Rats</p>

Ahmed

Mussari

Abdel-Hady

et al. 2019

DDDT

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BackgroundInjectable in situ gel (ISG) systems suffer from high initial drug release that may result in toxic effects.ObjectiveThis work aimed to develop an injectable sustained release rosuvastatin (RSV) ISG formulation with minimum initial drug burst and improved hyperlipidemic efficacy.MethodsSix formulation factors that affect RSV release after 0.5, 2 and 24 hrs have been screened and the significant ones were optimized utilizing an experimental design tool. The optimum ISG formulation components were physicochemically characterized. Kinetic treatment, dissolution efficiency and mean dissolution time were investigated for the developed ISG formulations. Pharmacodynamic effects of the optimized ISG formulation were studied and compared to ISG formulation loaded with free RSV and to a marketed oral drug product.ResultsThe concentration polylactide-co-ε-caprolactone (25: 75), the surfactant hydrophilic lipophilic balance (HLB) and the ratio of surfactant to polyethylene glycol 400 were significantly affecting the release of RSV during the first 24 h. Physicochemical characterization demonstrated complete dispersion of RSV in the polymeric matrix with slight changes in the drug crystalline structure. The optimized formulation demonstrated acceptable syringeability, good flow rate and was able to extend the in vitro drug release for 34 days. The ISG formulations complied with Weibull model. Pharmacodynamic study revealed a sustained reduction in the lipid profile that lasted for 21 days with a marked decrease in the lipid level during the first 24 hrs from the ISG system loaded with free RSV.ConclusionThe optimized RSV ISG formulation could be considered a promising strategy due to a reduction in dosing frequency and enhancement in hypolipidemic efficacy.

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Preparation and evaluation in vitro of salicylic acid-pachyman nanoparticles

Zhang

Shao

Xiao

et al. 2011

J. Wuhan Univ. Technol.-Mat. Sci. Edit.

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Pachyman based nanoparticles loading salicylic acid as model drug (SA-PNPs) were prepared by an inverse microemulsion crosslinking approach using epichlorohydrin (ECH) as crosslinker. The effects of crosslinking reaction time, initial volume ratio of oil to aqueous phase and dosage of crosslinker on the particle size of SA-PNPs were optimized by orthogonal experimental design. SA-PNPs prepared under the optimal conditions had the average size of 230 nm and high encapsulation effi ciency of 90%. The in vitro drug release was also investigated and the release data were analyzed using zero order, fi rst order and Higuchi's kinetics model. According to the determined coeffi cients, release data fi tted to Higuchi's model, which suggested that the release of SA from SA-PNPs in phosphate buffer (pH 7.4) was diffusion controlled release. The experimental results indicated that pachyman possesses a promising potential to be applied as nanocarriers for controlled drug release.

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Biodegradable polymers: Which, when and why?

Cited by 17 publications

References 60 publications

The Development, Formulation, and Assessment of Polyelectrolytic Complexes of an Anticancer Compound (Vinorelbine Tartarate)

The Development, Formulation, and Assessment of Polyelectrolytic Complexes of an Anticancer Compound (Vinorelbine Tartarate)

<p>An Optimized Surfactant-Based PEG-PLCL In Situ Gel Formulation For Enhanced Activity Of Rosuvastatin In Poloxamer-Induced Hyperlipidemic Rats</p>

Preparation and evaluation in vitro of salicylic acid-pachyman nanoparticles

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