Biodegradable polyurethane acrylate/HEMA-grafted nanodiamond composites with bone regenerative potential applications: structure, mechanical properties and biocompatibility

Alishiri, M.; Shojaei, Akbar; Abdekhodaie, Mohammad J.

doi:10.1039/c5ra19669h

Cited by 44 publications

(37 citation statements)

References 61 publications

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“…To obtain HEMA functionalized NDs (ND‐HEMA), ND‐COOH was first activated by thionyl chloride to obtain intermediate acyl chloride grafted ND (ND‐COCl), and then ND‐COCl was grafted by HEMA using the esterification reaction. Further details for the synthesis of ND‐HEMA can be found elsewhere . Scheme summarizes the steps used to modify the exterior surface of NDs with HEMA.…”

Section: Methodsmentioning

confidence: 99%

Morphology development and mechanical properties of unsaturated polyester resin containing nanodiamonds

Hashemi

Shojaei

2017

Polymer International

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Unsaturated polyester/styrene (UP) resin was filled with nanodiamonds (NDs) containing carboxyl and methacrylate functionalities using mechanical mixing. Field emission SEM exhibited a uniform dispersion of tightly bound aggregates of nanosized spherical NDs with good interfacial interaction. Rheological measurements exhibited a step increment in the shear viscosity of a UP/ND suspension at 0.6 wt% ND resembling a percolation state at this loading. Shear viscosity data supported by dynamic mechanical analysis results suggested the development of effective ND particles in which ND aggregates were covered by only polyester macromolecules. Accordingly, the morphology of UP/ND composites approached a quasi‐percolation state at 0.6 wt% in which effective ND particles were connected thoroughly, instead of direct ND−ND contact, forming a co‐continuous polyester phase covering the ND particles. Based on such morphology, DSC and Fourier transform infrared analysis suggested the development of heterogeneous microgels in cured UP resin containing NDs which in turn governed the overall mechanical properties of the composites. © 2017 Society of Chemical Industry

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Section: Methodsmentioning

confidence: 99%

Morphology development and mechanical properties of unsaturated polyester resin containing nanodiamonds

Hashemi

Shojaei

2017

Polymer International

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“…ND was also shown to be able to improve significantly the mechanical properties of non‐polar polymer (polyethylene) when suitable functionalization (alkyl functionalization) was used . The ability of ND to enhance the mechanical properties of biodegradable polymers was also investigated by Zhang et al with poly( l ‐lactide) using octadecylamine‐functionalized ND, by Alishiri et al with acrylated polyurethane using hydroxyethyl methacrylate‐functionalized ND and by Morimune et al with poly(vinyl alcohol) using untreated ND.…”

Section: Introductionmentioning

confidence: 99%

Morphological and mechanical properties of polyamide 6/nanodiamond composites prepared by melt mixing: effect of surface functionality of nanodiamond

Karami

Shojaei

2016

Polymer International

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Surface chemistry of as‐received nanodiamond (ND) was first tailored by dry thermal oxidation to obtain carboxylated ND (ND‐COOH) and by wet chemistry to obtain ethylenediamine‐functionalized ND (ND‐EDA). Then, the surface‐functionalized ND particles were dispersed in polyamide 6 (PA6) using the melt‐mixing method. Transmission optical and scanning electron microscopies indicated a fine dispersion at low nanodiamond concentrations, e.g. 0.25 wt%, particularly with ND‐EDA. Differential scanning calorimetry revealed that ND‐EDA favoured the α‐phase crystal and enhanced the degree of crystallinity of PA6. Experimental data indicated that ND‐EDA had considerably improved tensile properties at low concentration of 0.25 wt% compared to ND‐COOH, which was correlated to the fine dispersion and stronger and thicker interphase in the case of ND‐EDA. It was also found that the toughness of PA6 was improved on incorporation of ND‐EDA due to development of microcracking and crazing. © 2016 Society of Chemical Industry

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“…Further chemical modification of PUU macro chains by 0.03 and 0.06 mol of FKF also does not cause changes in the shape and angular position of amorphous halo, but only leads to the gradual decrease in its intensity, compared with the same diffraction peaks at diffraction of PUU (DADPh) and PUU (DADPh)-1 (curves [1][2][3][4]. This indicates the dominant contribution of DP and confirm the particularly amorphous structure of PUU.…”

Section: Figure 2 Dsc Studies Of Samples Puu (Dadph) (1) Puu (Dadphmentioning

confidence: 95%

“…Polyurethane is a biocompatible polymer with low cytotoxicity which makes it the potential candidate for applications in tissue engineering, material science, and drug delivery [2]. For example, new rapid hemostatic and mild polyurethane-urea foam (PUUF) wound dressing was prepared by the particle leaching method and vacuum freeze-drying method using 4,4-Methylenebis (cyclohexyl isocyanate), 4,4-diaminodicyclohexylmethane and poly (ethylene glycol) as raw materials.…”

Section: Introductionmentioning

confidence: 99%

Thermophysical Properties and X-Ray Structure Investigations of Polyurethane Ureas, Containing Folate Derivative of Ferrocene

Kulyk¹

2017

AJPC

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Thermophysical properties of polyurethane ureas by thermogravimetry and differential scanning calorimetry were studied. It was shown, that investigated polyurethane ureas are heat-resistant up to 523 K. The structure of polyurethane ureas, containing folate derivative of ferrocene, by wide-angle and small angle X-ray method for different content of folate-derivative of ferrocene was investigated. Wide-angle X-ray diffraction data revealed that the introduction of 0.01 mole of folate derivative of ferrocene to the PUU structure leads to the change of period alternating arrangement of flexible and rigid blocks of PUU, significant degradation of heterogeneous structure, but does not cause changes in amorphous structure of the polymer.

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Biodegradable polyurethane acrylate/HEMA-grafted nanodiamond composites with bone regenerative potential applications: structure, mechanical properties and biocompatibility

Abstract: It was found that ND-HEMA enhanced considerably the mechanical properties of biocompatible APUA at low concentrations, i.e. 1 wt%, while it retained the biocompatibility of the PAUA.

Cited by 44 publications

References 61 publications

Morphology development and mechanical properties of unsaturated polyester resin containing nanodiamonds

Morphology development and mechanical properties of unsaturated polyester resin containing nanodiamonds

Morphological and mechanical properties of polyamide 6/nanodiamond composites prepared by melt mixing: effect of surface functionality of nanodiamond

Thermophysical Properties and X-Ray Structure Investigations of Polyurethane Ureas, Containing Folate Derivative of Ferrocene

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