Biodegradable polyurethane composite scaffolds containing Bioglass® for bone tissue engineering

Ryszkowska, Joanna; Auguścik, Monika; Sheikh, Ann; Boccaccını, Aldo R.

doi:10.1016/j.compscitech.2010.05.011

Cited by 126 publications

(95 citation statements)

References 80 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…However, the work by Srinivasan et al showed a decrease in porosity ratio by addition of more nano-bioglass [30]. Overall, the ideal porosity percentage can be defined by the final application and also when there is a compromise between mechanical and biological properties [34].…”

Section: Thermal Analysismentioning

confidence: 99%

Fabrication and characterization of poly(octanediol citrate)/gallium-containing bioglass microcomposite scaffolds

et al. 2014

View full text Add to dashboard Cite

Bone can be affected by osteosarcomae requiring surgical excision of the tumor as part of the treatment regime. Complete removal of cancerous cells is difficult and conventionally requires the removal of a margin of safety around the tumor to offer improved patient prognosis. This work considers a novel series of composite scaffolds based on poly(octanediol citrate) (POC) impregnated with galliumbased bioglass microparticles for possible incorporation into bone following tumor removal. The objective of this research was to fabricate and characterize these scaffolds and subsequently report on their mechanical and biological properties. The porous microcomposite scaffolds with various concentrations of bioglass (10, 20, 30 wt%) incorporated were fabricated using a salt leaching technique. The scaffolds exhibited compression modulus in the range of 0.3-7 MPa. The addition of bioglass increased the mechanical properties even though porosity increased. Furthermore, increasing the concentration of bioglass had a significant influence on glass transition temperature from 2.5°C for the pure polymer to around 25°C for 30 % bioglass-containing composite. The ion release study revealed that composites containing 10 % bioglass had the highest ion release ratio after 28 days of soaking in phosphate buffered saline. The interaction of bioglass phase with POC led to the formation of additional ionic crosslinks aside from covalent crosslinks which further resulted in increased stiffness and decreased weight loss. The osteoblast cells were well attached and growth on composites and collagen synthesis increased particularly with the 10 % bioglass concentration.

show abstract

Section: Thermal Analysismentioning

confidence: 99%

Fabrication and characterization of poly(octanediol citrate)/gallium-containing bioglass microcomposite scaffolds

et al. 2014

View full text Add to dashboard Cite

show abstract

“…20 Composite scaffolds containing polymers and bioactive inorganic materials have attracted growing attention for bone tissue regeneration. 21 Therefore, it can be suggested that the introduction of the bioactive material n-BD into PCL-PEG-PCL was a good method to prepare bioactive composite scaffolds for bone repair.…”

Section: Results and Discussion Composition And Structure Of N-bd Andmentioning

confidence: 99%

Degradability, cytocompatibility, and osteogenesis of porous scaffolds of nanobredigite and PCL–PEG–PCL composite

Hou

Donghui

Zhao

et al. 2016

IJN

View full text Add to dashboard Cite

Biocomposite scaffolds were fabricated by incorporation of nanobredigite (n-BD) into the polymer of poly(ε-caprolactone)–poly(ethyleneglycol)–poly(ε-caprolactone) (PCL–PEG–PCL). The results revealed that the addition of n-BD into PCL–PEG–PCL significantly improved water absorption, compressive strength, and degradability of the scaffolds of n-BD/PCL–PEG–PCL composite (n-BPC) compared with PCL–PEG–PCL scaffolds alone. In addition, the proliferation and alkaline phosphatase activity of MG63 cells cultured on n-BPC scaffolds were obviously higher than that cultured on PCL–PEG–PCL scaffolds. Moreover, the results of the histological evaluation from the animal model revealed that the n-BPC scaffolds significantly improved new bone formation compared with the PCL–PEG–PCL scaffolds, indicating good osteogenesis. The n-BPC scaffolds with good biocompatibility could stimulate cell proliferation, differentiation, and bone tissue regeneration and would be an excellent candidate for bone defect repair.

show abstract

“…This could be explained by considerable structural changes connected with the reduction of chain lengths followed by eventual physical crosslinking of macromolecules after degradation [18,24].…”

Section: Resultsmentioning

confidence: 99%

Polyurethanes Based on Atactic Poly[(R,S)-3-hydroxybutyrate]: Preliminary Degradation Studies in Simulated Body Fluids

et al. 2014

View full text Add to dashboard Cite

The aliphatic polyurethanes based on atactic poly [(R,S)-3-hydroxybutyrate] (a-PHB) and commercial oligomerols: poly(e-caprolactone)diol and polyoxytetramethylenediol were investigated. a-PHB was obtained by anionic ring-opening polymerization of (R,S)-b-butyrolactone. The 4,4 0 -methylenedicyclohexyl diisocyanate and 1,4-butanediol were used as contributors of hard segments. The aim of the study was to determine the influence of synthetic, atactic a-PHB in soft segments of polyurethanes on their degradability in simulated body fluids (SBF) and Ringer solution. The incubation of polymer samples in both degradative solutions was carried out for 36 weeks. It was concluded that the presence of a-PHB in polyurethane structure accelerated their degradation in SBF and in Ringer solution and, protected the calcification process.

show abstract

Biodegradable polyurethane composite scaffolds containing Bioglass® for bone tissue engineering

Abstract: polyurethane composite scaffolds containing Bioglass® for bone tissue engineering.

Cited by 126 publications

References 80 publications

Fabrication and characterization of poly(octanediol citrate)/gallium-containing bioglass microcomposite scaffolds

Fabrication and characterization of poly(octanediol citrate)/gallium-containing bioglass microcomposite scaffolds

Degradability, cytocompatibility, and osteogenesis of porous scaffolds of nanobredigite and PCL–PEG–PCL composite

Polyurethanes Based on Atactic Poly[(R,S)-3-hydroxybutyrate]: Preliminary Degradation Studies in Simulated Body Fluids

Contact Info

Product

Resources

About

Biodegradable polyurethane composite scaffolds containing Bioglass® for bone tissue engineering

Abstract: polyurethane composite scaffolds containing Bioglass® for bone tissue engineering.

Cited by 126 publications

References 80 publications

Fabrication and characterization of poly(octanediol citrate)/gallium-containing bioglass microcomposite scaffolds

Fabrication and characterization of poly(octanediol citrate)/gallium-containing bioglass microcomposite scaffolds

Degradability, cytocompatibility, and osteogenesis of porous scaffolds of nanobredigite and PCL&ndash;PEG&ndash;PCL composite

Polyurethanes Based on Atactic Poly[(R,S)-3-hydroxybutyrate]: Preliminary Degradation Studies in Simulated Body Fluids

Contact Info

Product

Resources

About

Degradability, cytocompatibility, and osteogenesis of porous scaffolds of nanobredigite and PCL–PEG–PCL composite