Biodegradable scaffolds facilitate epiretinal transplantation of hiPSC-Derived retinal neurons in nonhuman primates

Luo, Ziming; Xian, Bikun; Li, Kang; Li, Kaijing; Yang, Runcai; Chen, Mengfei; Xu, Chaochao; Tang, Mingjun; Rong, Hui-feng; Hu, Dongpeng; Ye, Meifang; Yang, Sijing; Lu, Shoutao; Zhang, Haijun; Ge, Junbo

doi:10.1016/j.actbio.2021.07.040

Cited by 21 publications

(6 citation statements)

References 42 publications

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“…Thus, a cell replacement strategy was considered a potential therapy to treat RGC loss. In the past decade, scientists have been able to differentiate human stem cells into RGC-like cells [ 188 – 192 ]. However, how to scale up donor cells, promote long-term cell survival and enhance synaptic integration into the visual circuit remains a challenge for stem cell therapy [ 193 ].…”

Section: Current Therapy For Retinal Degenerationmentioning

confidence: 99%

The interplay of autophagy and oxidative stress in the pathogenesis and therapy of retinal degenerative diseases

et al. 2022

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Oxidative stress is mainly caused by intracellular reactive oxygen species (ROS) production, which is highly associated with normal physiological homeostasis and the pathogenesis of diseases, particularly ocular diseases. Autophagy is a self-clearance pathway that removes oxidized cellular components and regulates cellular ROS levels. ROS can modulate autophagy activity through transcriptional and posttranslational mechanisms. Autophagy further triggers transcription factor activation and degrades impaired organelles and proteins to eliminate excessive ROS in cells. Thus, autophagy may play an antioxidant role in protecting ocular cells from oxidative stress. Nevertheless, excessive autophagy may cause autophagic cell death. In this review, we summarize the mechanisms of interaction between ROS and autophagy and their roles in the pathogenesis of several ocular diseases, including glaucoma, age-related macular degeneration (AMD), diabetic retinopathy (DR), and optic nerve atrophy, which are major causes of blindness. The autophagy modulators used to treat ocular diseases are further discussed. The findings of the studies reviewed here might shed light on the development and use of autophagy modulators for the future treatment of ocular diseases.

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Section: Current Therapy For Retinal Degenerationmentioning

confidence: 99%

The interplay of autophagy and oxidative stress in the pathogenesis and therapy of retinal degenerative diseases

et al. 2022

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“…In addition to replacing dead cells, SC-derived RGCs also improve endogenous RGC survival [119,120]. A study in non-human primates showed that axons from donor RGCs were observed in the brain [121], suggesting that SC-derived RGC transplantation may restore the axon loss in the optic nerve with OPG. Whether the microenvironment of OPG in the optic nerve would affect donor RGC survival and their axon growth would be an interesting direction for future study.…”

Section: Discussionmentioning

confidence: 99%

The Neuroimmune Regulation and Potential Therapeutic Strategies of Optic Pathway Glioma

Irshad,

Huang,

Rodriguez

et al. 2023

Brain Sciences

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Optic pathway glioma (OPG) is one of the causes of pediatric visual impairment. Unfortunately, there is as yet no cure for such a disease. Understanding the underlying mechanisms and the potential therapeutic strategies may help to delay the progression of OPG and rescue the visual morbidities. Here, we provide an overview of preclinical OPG studies and the regulatory pathways controlling OPG pathophysiology. We next discuss the role of microenvironmental cells (neurons, T cells, and tumor-associated microglia and macrophages) in OPG development. Last, we provide insight into potential therapeutic strategies for treating OPG and promoting axon regeneration.

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“…One should be cautious in using biodegradable scaffolds in patients, as the by-products of biodegradation might be toxic to retinal cells. Moreover, bio-safety of scaffolds and its ability to support graft survival has been proven ( 54 , 55 ), further studies are required to determine the scaffold's role in establishing visual recovery.…”

Section: Polymeric Biomaterials and Posterior Segment Applicationsmentioning

confidence: 99%

“…Important aspects such as bio-distribution, metabolism and excretion mechanisms can affect the biocompatibility of the polymer significantly. While the systemic pharmacokinetics of polymers like PEG and PCL may have been established previously, their effects on local ocular tissue structure and function still needs to be studied in order to better understand the safety and clearance path of the byproducts while polymers are degrading ( 54 ).…”

Section: Translational Hurdlesmentioning

confidence: 99%

Polymeric biomaterials in the treatment of posterior segment diseases

et al. 2022

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Polymeric biomaterials are biological or synthetic substances which can be engineered to interact with biological systems for the diagnosis or treatment of diseases. These biomaterials have immense potential for treating eyes diseases, particularly the retina—a site of many inherited and acquired diseases. Polymeric biomaterials can be engineered to function both as an endotamponade agent and to prevent intraocular scarring in retinal detachment repair surgeries. They can also be designed as a drug delivery platform for treatment of retinal diseases. Finally, they can be used as scaffolds for cellular products and provide non-viral gene delivery solutions to the retina. This perspective article explains the role of polymeric biomaterials in the treatment of retinal conditions by highlighting recent advances being translated to clinical practice. The article will also identify potential hurdles to clinical translation as future research directions in the field.

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Biodegradable scaffolds facilitate epiretinal transplantation of hiPSC-Derived retinal neurons in nonhuman primates

Cited by 21 publications

References 42 publications

The interplay of autophagy and oxidative stress in the pathogenesis and therapy of retinal degenerative diseases

The interplay of autophagy and oxidative stress in the pathogenesis and therapy of retinal degenerative diseases

The Neuroimmune Regulation and Potential Therapeutic Strategies of Optic Pathway Glioma

Polymeric biomaterials in the treatment of posterior segment diseases

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