Biodegradable, spun nanocomposite polymeric fibrous dressings loaded with bioactive biomolecules for an effective wound healing: A review

Felgueiras, Helena P.; Tavares, Tânia D.; Amorim, M. T. Pessoa de

doi:10.1088/1757-899x/634/1/012033

Cited by 26 publications

(16 citation statements)

References 45 publications

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“…This technique allows to control the morphology, porosity and fiber diameter of the scaffold, to fit the requirements of specific applications, by adjusting the processing parameters, using simple and low maintenance settings [7]. These important adaptable characteristics make the electrospinning technique particularly suitable for the production of biomimetic nanofibrous scaffolds, providing new 2 of 33 generation strategies to restore, maintain or improve tissue functions [8,9]. These essential trademarks instigate cell adhesion, attachment, proliferation, differentiation and migration [10], while meeting the material requirements of biocompatibility, biodegradability, mechanical stability and nutrient transport throughout the assembly [11][12][13][14][15].…”

Section: Introductionmentioning

confidence: 99%

Poly(Vinyl Alcohol)-Based Nanofibrous Electrospun Scaffolds for Tissue Engineering Applications

2019

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Tissue engineering (TE) holds an enormous potential to develop functional scaffolds resembling the structural organization of native tissues, to improve or replace biological functions and prevent organ transplantation. Amongst the many scaffolding techniques, electrospinning has gained widespread interest because of its outstanding features that enable the production of non-woven fibrous structures with a dimensional organization similar to the extracellular matrix. Various polymers can be electrospun in the form of three-dimensional scaffolds. However, very few are successfully processed using environmentally friendly solvents; poly(vinyl alcohol) (PVA) is one of those. PVA has been investigated for TE scaffolding production due to its excellent biocompatibility, biodegradability, chemo-thermal stability, mechanical performance and, most importantly, because of its ability to be dissolved in aqueous solutions. Here, a complete overview of the applications and recent advances in PVA-based electrospun nanofibrous scaffolds fabrication is provided. The most important achievements in bone, cartilage, skin, vascular, neural and corneal biomedicine, using PVA as a base substrate, are highlighted. Additionally, general concepts concerning the electrospinning technique, the stability of PVA when processed, and crosslinking alternatives to glutaraldehyde are as well reviewed.

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Section: Introductionmentioning

confidence: 99%

Poly(Vinyl Alcohol)-Based Nanofibrous Electrospun Scaffolds for Tissue Engineering Applications

2019

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“…Most AMPs are produced by specific cells, at all times; however, there are those whose production is inducible. Still, they are quickly mobilized after microbial infection and act rapidly to neutralize a broad range of microbes (Figure 3) [149,150,[153][154][155][156]. To date, hundreds of AMPs have been identified and their importance in the innate immune system explored.…”

Section: Antimicrobial Peptides (Amps)mentioning

confidence: 99%

Biofunctionalization of Natural Fiber-Reinforced Biocomposites for Biomedical Applications

et al. 2020

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In the last ten years, environmental consciousness has increased worldwide, leading to the development of eco-friendly materials to replace synthetic ones. Natural fibers are extracted from renewable resources at low cost. Their combination with synthetic polymers as reinforcement materials has been an important step forward in that direction. The sustainability and excellent physical and biological (e.g., biocompatibility, antimicrobial activity) properties of these biocomposites have extended their application to the biomedical field. This paper offers a detailed overview of the extraction and separation processes applied to natural fibers and their posterior chemical and physical modifications for biocomposite fabrication. Because of the requirements for biomedical device production, specialized biomolecules are currently being incorporated onto these biocomposites. From antibiotics to peptides and plant extracts, to name a few, this review explores their impact on the final biocomposite product, in light of their individual or combined effect, and analyzes the most recurrent strategies for biomolecule immobilization.

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“…Engineered skin tissue and high-performance wound dressings would be an excellent solution. Although allografts and autografts have been the most obvious choice in the past, lately, temporary three-dimensional tissue engineering constructs mimicking the skin architecture and loaded with fibroblasts, keratinocytes and endothelial cells have gained more attention [10,125]. Biodegradable fiber-based structures have been proposed for the healing of dermal and epidermal injuries.…”

Section: Skinmentioning

confidence: 99%

“…In biomolecule delivery systems, the compatibility of the drug (antibiotic, growth factors, antimicrobial peptide, essential oil, plant extract, etc.) with the polymer is crucial for a successful outcome [5,9,10]. Still, challenges remain on this front due to the degradation or denaturation of the biological molecules when combined with organic solvents.…”

Section: Introductionmentioning

confidence: 99%

Spun Biotextiles in Tissue Engineering and Biomolecules Delivery Systems

et al. 2020

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Nowadays, tissue engineering is described as an interdisciplinary field that combines engineering principles and life sciences to generate implantable devices to repair, restore and/or improve functions of injured tissues. Such devices are designed to induce the interaction and integration of tissue and cells within the implantable matrices and are manufactured to meet the appropriate physical, mechanical and physiological local demands. Biodegradable constructs based on polymeric fibers are desirable for tissue engineering due to their large surface area, interconnectivity, open pore structure, and controlled mechanical strength. Additionally, biodegradable constructs are also very sought-out for biomolecule delivery systems with a target-directed action. In the present review, we explore the properties of some of the most common biodegradable polymers used in tissue engineering applications and biomolecule delivery systems and highlight their most important uses.

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Biodegradable, spun nanocomposite polymeric fibrous dressings loaded with bioactive biomolecules for an effective wound healing: A review

Cited by 26 publications

References 45 publications

Poly(Vinyl Alcohol)-Based Nanofibrous Electrospun Scaffolds for Tissue Engineering Applications

Poly(Vinyl Alcohol)-Based Nanofibrous Electrospun Scaffolds for Tissue Engineering Applications

Biofunctionalization of Natural Fiber-Reinforced Biocomposites for Biomedical Applications

Spun Biotextiles in Tissue Engineering and Biomolecules Delivery Systems

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