Biodegradable suture threads as controlled drug delivery systems

Silva, Milena Costa da; Leal, Rita de Cássia A.; Silva, Henrique Nunes da; Fook, Marcus Vinícius Lia

doi:10.1080/14328917.2019.1619982

Cited by 6 publications

(3 citation statements)

References 18 publications

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“…Tensile strength was measured using an universal testing machine (UTM; Instron, Norwood, MA, USA) with a length of approximately 10 mm as the distance of the clamps along the axis of the specimens, a crosshead speed of testing of 50 mm/min, a load cell of 100 N, a room temperature of approximately 20 • C, and a relative humidity of approximately 51% [21,22]. Moreover, elongation was measured as the displacement of the thread before its breakage during the measurement of its tensile strength [23].…”

Section: Methodsmentioning

confidence: 99%

Biomechanical Properties and Biocompatibility of a Non-Absorbable Elastic Thread

Choi¹,

Kang²,

Choi³

et al. 2019

JFB

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To date, extensive studies have been conducted to assess diverse types of sutures. But there is a paucity of data regarding biomechanical properties of commonly used suture materials. In the current experiment, we compared biomechanical properties and biocompatibility, such as tensile strength and elongation, the degree of bovine serum albumin (BSA) release, in vitro cytotoxicity and ex vivo frictional properties, between a non-absorbable elastic thread (NAT; HansBiomed Co. Ltd., Seoul, Korea) (NAT-R: NAT with a rough surface, NAT-S: NAT with a smooth surface) and the Elasticum® (Korpo SRL, Genova, Italy). The degree of tensile strength and elongation of Si threads was significantly higher in both the NAT-R and -S as compared with the Elasticum® (p < 0.05). Moreover, the degree of tensile strength and elongation of PET threads was significantly lower in both NAT-R and -S as compared with the Elasticum® (p < 0.05). Furthermore, the degree of tensile strength and elongation of braided Si/PET threads was significantly lower in NAT-S as compared with NAT-R and Elasticum® (p < 0.05). The degree of BSA release was significantly higher in the NAT-R as compared with Elasticum® and NAT-S throughout a 2-h period in the descending order (p < 0.05). The degree of cell viability was significantly higher in both NAT-R and -S as compared with Elasticum® (p < 0.05). The degree of coefficient of friction as well as the frictional force and strength was significantly higher in NAT-R as compared with NAT-S and Elasticum® (p < 0.05). NAT had a higher degree of biomechanical properties and biocompatibility as compared with Elasticum®. But further experimental and clinical studies are warranted to compare the efficacy, safety, and potential role as a carrier for drug delivery between NAT and Elasticum®.

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Section: Methodsmentioning

confidence: 99%

Biomechanical Properties and Biocompatibility of a Non-Absorbable Elastic Thread

Choi¹,

Kang²,

Choi³

et al. 2019

JFB

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“…The chitosan yarns were prepared using the wet spinning method adapted from previous work of Da Silva, Leal, Da Silva, and Fook (2019). First, the chitosan solution (3% w/v) was prepared by dissolving the polymer in aqueous solution of glacial acetic acid (1% v/v) in a volumetric flask, measuring the final volume of 100 ml.…”

Section: Methodsmentioning

confidence: 99%

Tubular chitosan device for use as prosthesis coating in vascular surgery

Macêdo

Lucena

Cerqueira

et al. 2021

RSD

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Chitosan is a natural, biodegradable, non-toxic and biocompatible polymer, with characteristics such as a healing, hemostatic, antimicrobial agent, among others. Therefore, the aim of this study is to develop a tubular chitosan device for use as a prosthetic coating application in vascular surgery. The chitosan wires were obtained by the spinning method in a 2M sodium hydroxide coagulant solution (NaOH) and used in the form of wires and screens as a reinforcement structure to obtain the tubes. In order to characterize the tubes, optical microscopy, contact angle, degree of swelling, in vitro biodegradation, cytotoxicity and tensile strength were used. The results indicated that the tubes have uniformity over the entire length and as for the resistance to the trace, the tube reinforced with mesh presented greater deformation, while the tube reinforced with wire presented a higher value of rupture stress. The degree of swelling was higher in chitosan tubes with mesh. As for the biodegradation test, it was observed that the lysozyme samples showed greater loss of mass and the cytotoxicity test confirmed the cell viability of the material, concluding that the tubes reinforced with chitosan wires are promising for use in vascular surgeries.

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“…CS solution (4% w / v ) was prepared as previously reported [ 22 , 23 , 24 ]. In short, CS was dissolved in a lactic acid aqueous solution (0.206 mol/L), in stoichiometric relationship with CS amine groups, at constant stirring (200 rpm) at 25 ± 1 °C for 2 h. The obtained CS solution was transferred to a syringe (20 mL capacity and 1 mm diameter outlet tip) for subsequent wet spinning.…”

Section: Methodsmentioning

confidence: 99%

Chitosan Woven Meshes: Influence of Threads Configuration on Mechanical, Morphological, and Physiological Properties

Silva

Santos

et al. 2020

Polymers

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This study aimed to develop meshes from the weaving of mono- and multifilament wet-spun chitosan (CS), for possible biomedical applications. In the wet-spinning process, CS solution (4% w/v) was extruded in a coagulation bath containing 70% sodium hydroxide solution (0.5 M), and 30% methanol was used. The multifilament thread was prepared by twisted of two and three monofilaments. CS threads obtained were characterized by tensile tests and scanning electron microscopy (SEM). Moreover, it was verified from the morphological tests that threads preserve the characteristics of the individual filaments and present typical “skin-core” microstructure obtained by wet spinning. CS woven meshes obtained were evaluated by optical microscopy (OM), tensile test, swelling degree, and in vitro enzymatic biodegradation. Mechanical properties, biodegradation rate, and amount of fluid absorbed of CS woven meshes were influenced by thread configuration. Hydrated CS meshes showed a larger elastic zone than the dry state. Therefore, CS woven meshes were obtained with modular properties from thread configuration used in weaving, suggesting potential applications in the biomedical field, like dressings, controlled drug delivery systems, or mechanical support.

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Biodegradable suture threads as controlled drug delivery systems

Cited by 6 publications

References 18 publications

Biomechanical Properties and Biocompatibility of a Non-Absorbable Elastic Thread

Biomechanical Properties and Biocompatibility of a Non-Absorbable Elastic Thread

Tubular chitosan device for use as prosthesis coating in vascular surgery

Chitosan Woven Meshes: Influence of Threads Configuration on Mechanical, Morphological, and Physiological Properties

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