Biodegradable Thermoresponsive Microparticle Dispersions for Injectable Cell Delivery Prepared Using a Single‐Step Process

Abstract

Surface‐engineered microparticles with a biodegradable polymer core and a programmable thermoresponsive biocompatible copolymer corona are produced. The particles form free‐flowing dispersions below 37 °C, but form porous space‐filling gels above this temperature, as a result of chain collapse of the copolymer corona. When particles are mixed with biological materials, they form encapsulating gels that can support cell growth.

Thermo‐Switchable Materials Prepared Using the OEGMA‐Platform

“…[ 55,56 ] poly( ε -caprolactone) particles) with OEGMA-based copolymers. [ 73,74 ] Above the LCST of these thermoresponsive shells, these microparticles aggregated into compact biocompatible scaffolds, which allowed the 3D encapsulation of living cells (Figure 2 ).…”

Copolymers based on azidopentyl-2-oxazoline: Synthesis, characterization and LCST behavior

“…These ''smart" polymers can respond to stimuli such as pH, temperature, ionic strength, electric or magnetic field, light and/or chemical and biological stimuli and consequently have a wide range of applications that include sensors, drug delivery, gene delivery and tissue engineering. In cases where the external stimulus applied is temperature, the polymer is said to exhibit thermoresponsive properties [4][5][6]. While both upper critical solution temperature (UCST) and lower critical solution temperature (LCST) behaviors are reported for polymer solutions, hydrophilic polymers exhibiting a LCST behavior are more frequently used for biomedical applications.…”

Synthesis and aggregation properties in water solution of comblike methacrylic polymers with oligo(propylene glycol)‐block‐oligo(ethylene glycol) as side chains

“…However, the controlled copolymerization of both monomers OEGMA and OPGMA has been carried out, leading to polymers with interesting properties and applicability in the delivery of drugs and cells. 9,10,26 Taking all these facts into account, in this work is explored a novel route to prepare new well-controlled amphiphilic block methacrylic copolymers based on oligo(ethylene glycol) (OEG) and OPGMA. In a first step, P(OPGMA) with different molecular weights was obtained by the ATRP of OPGMA macromonomer end capped with a hydroxyl group.…”