Biodegradable urethral stents

Tammela, Teuvo L.J.; Talja, Martti

doi:10.1046/j.1464-410x.2003.04496.x

Cited by 29 publications

(17 citation statements)

References 53 publications

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“…Biodegradable stents, drug-eluting stents, or radioisotopefilled balloon dilation are under investigation to prevent tissue hyperplasia [13][14][15]. For urethral stents, biodegradable stents will obviate the need for removal, and drugeluting stents or radioisotope-filled balloon dilation will make removal easier.…”

Section: Discussionmentioning

confidence: 99%

Removal of retrievable self-expandable urethral stents: experience in 58 stents

et al. 2006

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The purpose of this study was to retrospectively evaluate the safety and efficacy of removing retrievable self-expandable urethral stents using a retrieval hook wire. Under fluoroscopic guidance, the removal of 58 polyurethane or PTFE (polytetrafluoroethylene)-covered stents was attempted in 33 patients using a retrieval hook wire. Indications for removal were elective removal (n = 21), stent migration (n = 19), formation of tissue hyperplasia around or inside of the stent (n = 14), stent deformity (n = 3), and severe pain (n = 1). The mean time the stents remained in place was 64.8 +/- 42.9 days (range, 1-177 days). Fifty-six (97%) of the 58 stents were successfully removed using the retrieval hook wire despite the following difficulties; hook wire disconnection (n = 2), untied drawstrings (n = 3), and polyurethane membrane disruption/separation (n = 4). The removal procedure using a retrieval hook wire failed in two stents (3%) which had migrated into the urinary bladder. One of the two stents with migration into the urinary bladder was removed using a snare through the cystostomy route. The overall complication rate was 14% (seven hematuria cases and one urethral tear case), and all were minor and spontaneously resolved without further treatment. In conclusion, removal of retrievable urethral stents using a retrieval hook wire was safe and effective despite some technical difficulties. It is a useful method for allowing temporary stent placement and solving various complications of stent use.

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Section: Discussionmentioning

confidence: 99%

Removal of retrievable self-expandable urethral stents: experience in 58 stents

et al. 2006

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“…The ''proof-of-concept'' of biodegradable urethral stents should be credited to Torma¨la¨and co-workers in the early 1990s in Finland. After extensive experience gathered on the usage of biodegradable polymers as orthopedic fixation devices, the first biodegradable urethral stent made of selfreinforced poly(L-lactic acid) was tested in rabbits in 1993, 70 but still today, concerns about the true benefits of the employment of urethral stents, either permanent or temporary, exist among urologists. 47 Nevertheless, the group has published innumerable experimental studies, either in vivo or in vitro, regarding different aspects of biodegradable stent technology that reach far beyond the urologic application, such as e.g.…”

Section: Absorbable Polymer Stentsmentioning

confidence: 99%

Biodegradable Stents: Biomechanical Modeling Challenges and Opportunities

Moore

Soares

Rajagopal

2010

Cardiovasc Eng Tech

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Biodegradable implants show great potential in many areas of medicine, and have already demonstrated success in simple applications such as sutures. For more complex devices, such as vascular stents, there are considerable challenges associated with the use of biodegradable materials. These materials typically are weaker than the metals currently used to construct stents, so it is difficult to ensure sufficient strength to prop open the artery and alleviate symptoms acutely. It is even more challenging to design a stent that provides structural support for a predictable, appropriate time to facilitate artery healing. These challenges are evident when one considers that there are no biodegradable stents on the US market despite more than 20 years of development efforts. This review summarizes previous efforts at implementing biodegradable stents, discusses the specific challenges involved, and presents a recently developed biodegradable material modeling framework that can benefit this exciting field.

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“…The failure criteria for maximum strength as a function of degradation time have traditionally been modeled according to a first order kinetics. Many examples of this kind of design challenge can be found in the medical field, ranging from biodegradable sutures [19], pins and screws for orthopedic surgery [27], local drug delivery devices [18], tissue engineering scaffolds [20], biodegradable ligaments [37], biodegradable endovascular [10] and urethral stents [31]. [6] In this work, hyper elastic constitutive models, such as the Neo-Hokean, the MooneyRivlin modified and the second reduced order will also be discussed.…”

Section: Introductionmentioning

confidence: 99%