Biodegradable π-Conjugated Oligomer Nanoparticles with High Photothermal Conversion Efficiency for Cancer Theranostics

Li, Xiaozhen; Liu, Lu; Li, Shengliang; Wan, Yingpeng; Chen, Jia‐Xiong; Tian, Shuang; Huang, Zhongming; Xiao, Yafang; Cui, Xiao; Xiang, Chengyang; Tan, Qinglong; Zhang, Xiaohong; Guo, Weisheng; Liang, Xing‐Jie; Lee, Chun‐Sing

doi:10.1021/acsnano.9b05383

Cited by 219 publications

(155 citation statements)

References 61 publications

Supporting

Mentioning

154

Contrasting

Unclassified

Order By: Relevance

“…Interestingly, owing to the strong TICT effect, its absorption can be red‐shifted to the NIR‐region, further benefiting photothermal conversion under laser irradiation of 808 nm. The maximum PTCE of C6TI in the aggregation state thus can reach 90.0 %, which is much higher than most reported photothermal agents including ICG (Table S1) . Thanks to its excellent PTCE, C6TI serves as a NIR‐triggered PTT agent that can locally heat the tumor region to 53.4 °C and further induce complete cell necrosis (Figures S2–4).…”

Section: Methodsmentioning

confidence: 90%

A Photoinduced Nonadiabatic Decay‐Guided Molecular Motor Triggers Effective Photothermal Conversion for Cancer Therapy

Zhang

Yang

et al. 2020

Angewandte Chemie

View full text Add to dashboard Cite

It remains highly challenging to identify small molecule‐based photothermal agents with a high photothermal conversion efficiency (PTCE). Herein, we adopt a double bond‐based molecular motor concept to develop a new class of small photothermal agents to break the current design bottleneck. As the double‐bond is twisted by strong twisted intramolecular charge transfer (TICT) upon irradiation, the excited agents can deactivate non‐radiatively through the conical intersection (CI) of internal conversion, which is called photoinduced nonadiabatic decay. Such agents possess a high PTCE of 90.0 %, facilitating low‐temperature photothermal therapy in the presence of a heat shock protein 70 inhibitor. In addition, the behavior and mechanism of NIR laser‐triggered molecular motions for generating heat through the CI pathway have been further understood through theoretical and experimental evidence, providing a design principle for highly efficient photothermal and photoacoustic agents.

show abstract

Section: Methodsmentioning

confidence: 90%

A Photoinduced Nonadiabatic Decay‐Guided Molecular Motor Triggers Effective Photothermal Conversion for Cancer Therapy

Zhang

Yang

et al. 2020

Angewandte Chemie

View full text Add to dashboard Cite

show abstract

“…Herein, many immense efforts have been devoted to designing photo‐driven ROS‐ECBs that transform endogenous H 2 O 2 to O 2 for alleviating tumor hypoxia. These photo‐driven ROS‐ECBs could be partitioned into three categories, including catalase, MnO 2 , and the other alternative types (Fan et al, 2015; Li, Cheng, et al, 2017; Li, Wang, et al, 2017; Li et al, 2019). It has been demonstrated that catalase could efficiently catalyze H 2 O 2 to provide O 2 and subsequently relieve tumor hypoxia (Phua et al, 2019).…”

Section: Energy‐converting Biomaterials For Cancer Therapymentioning

confidence: 99%

“…Semiconducting polymers‐based photo‐converted H‐ECBs, such as polyaniline, polyaniline (PANI), polypyrrole (PPy), and conjugated donor–acceptor (D‐A) structures, are emerging as the distinctive hyperthermia agents due to their excellent optical and photothermal properties (Li, Liu, et al, 2019; Liu et al, 2020; Wang, Ma, Sheng, Wang, & Xu, 2018; Yang et al, 2020). For instance, Li, Xie, et al (2018) constructed a semiconducting polymer amphiphile (PCB1) with photothermic activity for enhanced cancer therapy (Figure 7c).…”

Section: Energy‐converting Biomaterials For Cancer Therapymentioning

confidence: 99%

Energy‐converting biomaterials for cancer therapy: Category, efficiency, and biosafety

Dong

Sun

et al. 2020

WIREs Nanomed Nanobiotechnol

View full text Add to dashboard Cite

Energy‐converting biomaterials (ECBs)‐mediated cancer‐therapeutic modalities have been extensively explored, which have achieved remarkable benefits to overwhelm the obstacles of traditional cancer‐treatment modalities. Energy‐driven cancer‐therapeutic modalities feature their distinctive merits, including noninvasiveness, low mammalian toxicity, adequate therapeutic outcome, and optimistical synergistic therapeutics. In this advanced review, the prevailing mainstream ECBs can be divided into two sections: Reactive oxygen species (ROS)‐associated energy‐converting biomaterials (ROS‐ECBs) and hyperthermia‐related energy‐converting biomaterials (H‐ECBs). On the one hand, ROS‐ECBs can transfer exogenous or endogenous energy (such as light, radiation, ultrasound, or chemical) to generate and release highly toxic ROS for inducing tumor cell apoptosis/necrosis, including photo‐driven ROS‐ECBs for photodynamic therapy, radiation‐driven ROS‐ECBs for radiotherapy, ultrasound‐driven ROS‐ECBs for sonodynamic therapy, and chemical‐driven ROS‐ECBs for chemodynamic therapy. On the other hand, H‐ECBs could translate the external energy (such as light and magnetic) into heat for killing tumor cells, including photo‐converted H‐ECBs for photothermal therapy and magnetic‐converted H‐ECBs for magnetic hyperthermia therapy. Additionally, the biosafety issues of ECBs are expounded preliminarily, guaranteeing the ever‐stringent requirements of clinical translation. Finally, we discussed the prospects and facing challenges for constructing the new‐generation ECBs for establishing intriguing energy‐driven cancer‐therapeutic modalities. This article is categorized under: Nanotechnology Approaches to Biology >Nanoscale Systems in Biology

show abstract

“…[12][13][14][15] Diverse photothermal agents, including inorganic and organic materials, have been developed. [16][17][18][19][20][21] In general, photothermal agents can also simultaneously achieve photoacoustic imaging (PAI) owing to their efficient heating output that generates ultrasonic vibration within biological tissue. [22][23][24][25] The main advantage of PAI is the light in/sound out paradigm that would achieve an ultra-deep (5-7 cm) tissue imaging with high spatial resolution, which makes it a very useful tool for deep-tissue imaging.…”

Section: Introductionmentioning

confidence: 99%

Single‐Photomolecular Nanotheranostics for Synergetic Near‐Infrared Fluorescence and Photoacoustic Imaging‐Guided Highly Effective Photothermal Ablation

Xiao

Xiang

et al. 2020

Small

Self Cite

View full text Add to dashboard Cite

Multi‐modality imaging‐guided cancer therapy is considered as a powerful theranostic platform enabling simultaneous precise diagnosis and treatment of cancer. However, recently reported multifunctional systems with multiple components and sophisticate structures remain major obstacles for further clinical translation. In this work, a single‐photomolecular theranostic nanoplatform is fabricated via a facile nanoprecipitation strategy. By encapsulating a semiconductor oligomer (IT‐S) into an amphiphilic lipid, water‐dispersible IT‐S nanoparticles (IT‐S NPs) are prepared. The obtained IT‐S NPs have a very simple construction and possess ultra‐stable near‐infrared (NIR) fluorescence (FL)/photoacoustic (PA) dual‐modal imaging and high photothermal conversion efficiency of 72.3%. Accurate spatiotemporal distribution profiles of IT‐S NPs are successfully visualized by NIR FL/PA dual‐modal imaging. With the comprehensive in vivo imaging information provided by IT‐S NPs, tumor photothermal ablation is readily realized under precise manipulation of laser irradiation, which greatly improves the therapeutic efficacy without any obvious side effects. Therefore, the IT‐S NPs allow high tumor therapeutic efficacy under the precise guidance of FL/PA imaging techniques and thus hold great potential as an effective theranostic platform for future clinical applications.

show abstract

Biodegradable π-Conjugated Oligomer Nanoparticles with High Photothermal Conversion Efficiency for Cancer Theranostics

Cited by 219 publications

References 61 publications

A Photoinduced Nonadiabatic Decay‐Guided Molecular Motor Triggers Effective Photothermal Conversion for Cancer Therapy

A Photoinduced Nonadiabatic Decay‐Guided Molecular Motor Triggers Effective Photothermal Conversion for Cancer Therapy

Energy‐converting biomaterials for cancer therapy: Category, efficiency, and biosafety

Single‐Photomolecular Nanotheranostics for Synergetic Near‐Infrared Fluorescence and Photoacoustic Imaging‐Guided Highly Effective Photothermal Ablation

Contact Info

Product

Resources

About