Biodegradation and Biocompatibility of Polyorganophosphazene

Abstract

We investigated biodegradation and biocompatibility of poly(organophosphazenes). We prepared poly(organophosphazenes) having different side chain groups. The blood compatibility of poly(organophosphazenes) containing fluorinated side groups, poly(bis[trifluoroethoxy]phosphazene) (PbFP) and poly([trifluoroethoxy][ethyl glycinate]phosphazene) (PFGP), without heparinization were evaluated in vitro. The deformation and aggregation of platelets adhered on PbFP and PFGP were not observed and they suppressed platelet activation. Additionally, PbFP and PFGP showed a higher degradation rate, despite their high hydrophobic nature. We found that the high mobility of water in PbFP and PFGP was one of the important factors facilitating their degradation. Their polymer structures were formed in a more open nature, indicating that water easily attacked the backbone of the phosphorus and nitrogen atoms in the poly(organophosphazene). On the other hand, the proliferation of HeLa cells cultured on poly(organophosphazene) was reduced compared with that on the control tissue culture polystyrene.

Polímeros usados como sistemas de transporte de princípios ativos

“…Com o objetivo de aplicação como biomateriais, foram sugeridos como grupos substituintes, diferentes aminoácidos, uma vez que estes últimos conferem biocompatibilidade e biodegradabilidade ao polímero. Além disso, a presença do grupo imidazol parece aumentar a degradação hidrolítica originando intermediários relativamente estáveis e, finalmente, moléculas fisiológicas de baixo valor de MM [76] . Allcock et al [77,78] prepararam derivados de poliorganofosfazenos para várias aplicações biomédicas.…”

Sonochemical synthesis of cyclophosphazene bridged mesoporous organosilicas and their application in methyl orange, congo red and Cr(vi) removal

“…The phosphazene and cyclophosphazene-based materials have number of applications in various fields due to their excellent thermal properties, biocompatibility, and biodegradability. [24][25] With the increase in the industrialization, there was a drastic increase in the pollutants in the ground water. Both synthetic organic dyes and heavy metals are major contributor for this ground water pollution, which is a big concern for the environment.…”

Influence of degradation on inflammatory profile of polyphosphazene coated PMMA and trisacryl gelatin microspheres in a sheep uterine artery embolization model

“…These first coated embolization microsphere are constituted of a PMMA hydrogel core and a PP coating. PP is a family of inorganic polymers with the repeating unit (eRRP ¼ Ne) [16] which are generally used in the manufacturing of biodegradable devices including drug release system [17,18] and matrices [19,20]. The PP formulation for PMMA-PPms coating is poly[bis(trifluoroethoxy)phosphazene], also known as Polyzene Ò -F (CeloNova BioSciences), where R radical chains are trifluoroethoxyl groups (eOCH 2 CF 3 ).…”