Biodegradation and Medical Application of Microbial Poly(3-hydroxybutyrate)

Artsis, M. I.; Бонарцев, А. П.; Иорданский, А. Л.; Бонарцева, Г. А.; Заиков, Г. Е.

doi:10.1080/15421401003726519

Cited by 21 publications

(27 citation statements)

References 110 publications

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“…The average number of bond cleavage per PHBV polymer molecule ( N ) was calculated using the Eq. (2):

{N = \overset{M}{true}}_{n}^{0} / {\overset{false¯}{M}}_{n} - 1

where

{\overset{false¯}{M}}_{n}^{0}

and

{\overset{false¯}{M}}_{n}

are the number average molecular weights of the PHBV powder and scaffolds, respectively …”

Section: Methodsmentioning

confidence: 99%

Akermanite reinforced PHBV scaffolds manufactured using selective laser sintering

Diermann

Dargusch

et al. 2019

J Biomed Mater Res

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Scaffold assisted tissue engineering presents a promising approach to repair diseased and fractured bone. For successful bone repair, scaffolds need to be made of biomaterials that degrade with time and promote osteogenesis. Compared to the commonly used ß‐tricalcium phosphate scaffolds, Akermanite (AKM) scaffolds were found to degrade faster and promote more osteogenesis. The objective of this study is to synthesize AKM micro and nanoparticle reinforced poly(3‐hydroxybutyrate‐co‐3‐hydroxyvalerate; PHBV) composite scaffolds using selective laser sintering (SLS). The synthesized composite scaffolds had an interconnected porous microstructure (61–64% relative porosity), large specific surface areas (31.1–64.2 mm−1) and pore sizes ranging from 303 to 366 and 279 to 357 μm in the normal and lateral direction, respectively, which are suitable for bone tissue repair. The observed hydrophilic nature of the scaffolds and the swift water uptake was due to the introduction of numerous carboxylic acid groups on the scaffold surface after SLS, circumventing the need for postprocessing. For the composite scaffolds, large amounts of AKM particles were exposed on the skeleton surface, which is a requirement for cell attachment. In addition, the particles embedded inside the skeleton helped to significantly reinforce the scaffold structure. The compressive strength and modulus of the composite scaffolds were up to 7.4 and 103 MPa, respectively, which are 149 and 197% of that of the pure PHBV scaffolds. © 2019 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 107B:2596–2610, 2019.

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“…The average number of bond cleavage per PHBV polymer molecule ( N ) was calculated using the Eq. (2):

{N = \overset{M}{true}}_{n}^{0} / {\overset{false¯}{M}}_{n} - 1

where

{\overset{false¯}{M}}_{n}^{0}

and

{\overset{false¯}{M}}_{n}

are the number average molecular weights of the PHBV powder and scaffolds, respectively …”

Section: Methodsmentioning

confidence: 99%

Akermanite reinforced PHBV scaffolds manufactured using selective laser sintering

Diermann

Dargusch

et al. 2019

J Biomed Mater Res

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“…39,40 According to the ISO/TR 7405-1984(f), a sample is considered hemolytic only when the hemolytic activity is above 5%. In our study, the hemolysis levels were very low (0.8% for MNS, 1.0% for MNC_DSW, and 1.4% for MNS_RP).…”

Section: Hemolytic Activity Of Phbv Mns and Mncmentioning

confidence: 99%

Biocompatibility of Dead Sea Water and retinyl palmitate carrying poly(3-hydroxybutyrate-co-3-hydroxyvalerate) micro/nanoparticles designed for transdermal skin therapy

Eke

Goñi‐de‐Cerio

Suárez-Merino

et al. 2015

Journal of Bioactive and Compatible Polymers

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In this study, novel drug carriers were developed for the treatment of skin conditions such as psoriasis, aging, or ultraviolet damage using micro/nanocapsules and micro/nanospheres of poly(3-hydroxybutyrate-co-3-hydroxyvalerate). The sizes of the particles were in the micron range and were loaded with retinyl palmitate and Dead Sea Water. In some tests, MgCl 2 was used as a substitute for Dead Sea Water for accurate determination of released ions of Dead Sea Water. Encapsulation efficiency and loading of water-soluble excipients Dead Sea Water and MgCl 2 were almost eight times lower than the hydrophobic compound retinyl palmitate. The particles were not cytotoxic as determined with the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide test using L929 mouse fibroblasts, BALB/3T3 mouse embryo fibroblasts, and HaCaT human keratinocytes. Ames test showed that the carriers were not genotoxic. The particles penetrated the membrane of human osteosarcoma cells Saos 2 and accumulated in their cytoplasm. No reactive oxygen species production could be detected which indicated low or

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“…It elicits minimal acute inflammation, abscesses, and tissue necrosis (Artsis et al, 2010). It elicits minimal acute inflammation, abscesses, and tissue necrosis (Artsis et al, 2010).…”

Section: Synthetic Biomaterialsmentioning

confidence: 99%

“…It elicits minimal acute inflammation, abscesses, and tissue necrosis (Artsis et al, 2010). However, the intermediate degradation product of PHB is biocompatible and not acidic unlike that of PGA and PLA (Artsis et al, 2010). PHB evokes a mild tissue response similar to that of PGA and PLA.…”

Section: Synthetic Biomaterialsmentioning

confidence: 99%

The Acquired Immune System Response to Biomaterials, Including Both Naturally Occurring and Synthetic Biomaterials

Fishman

Wiles²,

Wood

2015

Host Response to Biomaterials

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Biodegradation and Medical Application of Microbial Poly(3-hydroxybutyrate)

Cited by 21 publications

References 110 publications

Akermanite reinforced PHBV scaffolds manufactured using selective laser sintering

Akermanite reinforced PHBV scaffolds manufactured using selective laser sintering

Biocompatibility of Dead Sea Water and retinyl palmitate carrying poly(3-hydroxybutyrate-co-3-hydroxyvalerate) micro/nanoparticles designed for transdermal skin therapy

The Acquired Immune System Response to Biomaterials, Including Both Naturally Occurring and Synthetic Biomaterials

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