Biodegradation behavior of ultra-high-strength hydroxyapatite/poly (l-lactide) composite rods for internal fixation of bone fractures

Furukawa, Taizo; Matsusue, Yoshitaka; Yasunaga, Tsunoru; Shikinami, Yasuo; Okuno, Masaki; Nakamura, Takashi

doi:10.1016/s0142-9612(99)00232-x

Cited by 204 publications

(114 citation statements)

References 37 publications

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“…Due to the high viscosity of the polymer melt, it is difficult to gain a good impregnation and wet-out of the fibre surface by using the LS technique, which often result in poor fibre/matrix adhesion. Poor interfacial bonding is more vulnerable to fluid ingress through the interfaces under aqueous environments, which leads to a rapid loss of mechanical properties and early stage failure of the composites [18]. As such, it is of paramount importance for bioresorbable fibre reinforced composites to achieve strong fibre/matrix adhesion in order for their successful application in the field of hard tissue repair.…”

Section: Introductionmentioning

confidence: 99%

In-situ polymerisation of fully bioresorbable polycaprolactone/phosphate glass fibre composites: In vitro degradation and mechanical properties

Chen

Parsons

Felfel

et al. 2016

Journal of the Mechanical Behavior of Biomedical Materials

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Fully bioresorbable composites have been investigated in order to replace metal implant plates used for hard tissue repair. Retention of the composite mechanical properties within a physiological environment has been shown to be significantly affected due to loss of the integrity of the fibre/matrix interface. This study investigated phosphate based glass fibre (PGF) reinforced polycaprolactone (PCL) composites with 20%, 35% and 50% fibre volume fractions (Vf) manufactured via an in-situ polymerisation (ISP) process and a conventional laminate stacking (LS) followed by compression moulding. Reinforcing efficiency between the LS and ISP manufacturing process was compared, and the ISP composites revealed significant improvements in mechanical properties when compared to LS composites. The degradation profiles and mechanical properties were monitored in phosphate buffered saline (PBS) at 37°C for 28 days. ISP composites revealed significantly less media uptake and mass loss (p<0.001) throughout the degradation period. The initial flexural properties of ISP composites were substantially higher (p<0.0001) than those of the LS composites, which showed that the ISP manufacturing process provided a significantly enhanced reinforcement effect than the LS process. During the degradation study, statistically higher flexural property retention profiles were also seen for the ISP composites compared to LS composites. SEM micrographs of fracture surfaces for the LS composites revealed dry fibre bundles and poor fibre dispersion with polymer rich zones, which indicated poor interfacial bonding, distribution and adhesion. In contrast, evenly distributed fibres without dry fibre bundles or polymer rich zones, were clearly observed for the ISP composite samples, which showed that a superior fibre/matrix interface was achieved with highly improved adhesion.

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Section: Introductionmentioning

confidence: 99%

In-situ polymerisation of fully bioresorbable polycaprolactone/phosphate glass fibre composites: In vitro degradation and mechanical properties

Chen

Parsons

Felfel

et al. 2016

Journal of the Mechanical Behavior of Biomedical Materials

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“…This indicates that the osteoconductive effect of the biomaterial, similar to the examined ones, is necessary for higher levels of osteogenesis and complete healing. In the subgroup where HAp-PLLA composite was implanted, 24 weeks after implantation, besides intensive formation of a new bone, increased binding, as well as migration and distribution of vascular and osteogenic cells within remnants of implanted material were noticed, which confirmed the osteoconductive effect of that biocomposite [9][10][11][12][13][14].…”

Section: Discussionmentioning

confidence: 85%

“…The same final results as in the case of the HAp-PLLA composite biomaterial used alone, were found after the intraperitoneal implantation of a mixture of bone powder and the HAp-PLLA composite. The HAp-PLLA composite material was successfully used in the form of rods and tested for internal fixation of bone fractures [14][15][16].…”

Section: Introductionmentioning

confidence: 99%

Repair of Bone Tissue Affected by Osteoporosis with Hydroxyapatite-Poly-L-lactide (HAp-PLLA) With and Without Blood Plasma

et al. 2005

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The aim of this study is to examine the reparatory ability of the synthetic biomaterial hydroxyapatite-poly-L-lactide (HAp-PLLA), the replacement of alveolar ridge, and rehabilitation of bone defects caused by osteoporosis, in an experimental group of animals. The experiments are performed on syngeneic Sprague Dawley rats. Osteoporosis is induced by glucocorticoids in rats during a 12-week period. After this, the experimental group of animals is divided into five subgroups. An artificial defect is made in the alveolar bone on the left side of the mandible. In one group of animals, the defect is left to heal by itself, while in other groups, pure HAp-PLLA or one mixed with plasma is implanted. The best results are achieved by the implantation of the HAp-PLLA composite biomaterial mixed with autologous plasma. Formation of a new mandibular bone is seen, growing intensely, leading to rapid osteogenesis.

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“…Furukawa et al and Heidemann et al have already investigated the incorporation of hydroxyapatite and sodium hydrogenphosphate to aliphatic polyesters. All results are based on injection or compression moulded parts respectively foils [11][12][13][14][15][16][17][18][19][20][21][22][23][24][25]. The incorporation of buffer systems into melt spun fibres was investigated from Schuster et al In various works the incorporation of buffer systems in fibres could be shown [26][27][28].…”

Section: Introductionmentioning

confidence: 99%

Microgel-functionalised fibres with pH-optimised degradation behaviour – a promising approach for short-term medical applications

et al. 2015

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Resorbable polymers have been established for several decades in biomedical applications. The most frequently used resorbable polymers are still the aliphatic polyesters polylactides (PLA), polyglycolid (PGA) and polycaprolactone (PCL) homo-and copolymers. However, inherent pH dropping during degradation of some biomaterials may provoke inflammation and, thus, hamper the healing process. In this study we investigate the manufacturing method of microgel functionalised PLA Fibres in a dry-spinning process and the buffering effect of the poly(N-vinylcaprolactam-co-acetoacetoxyethyl methacrylate) vinylimidazole (VCL/AAEM/Vlm) microgels during the degradation of the fibres. Furthermore we examine the biocompatibility of the produced fibres and established a mathematical model to describe and analyse the pH level in the vicinity of the PLA fibre.

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Biodegradation behavior of ultra-high-strength hydroxyapatite/poly (l-lactide) composite rods for internal fixation of bone fractures

Cited by 204 publications

References 37 publications

In-situ polymerisation of fully bioresorbable polycaprolactone/phosphate glass fibre composites: In vitro degradation and mechanical properties

In-situ polymerisation of fully bioresorbable polycaprolactone/phosphate glass fibre composites: In vitro degradation and mechanical properties

Repair of Bone Tissue Affected by Osteoporosis with Hydroxyapatite-Poly-L-lactide (HAp-PLLA) With and Without Blood Plasma

Microgel-functionalised fibres with pH-optimised degradation behaviour – a promising approach for short-term medical applications

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