Biodegradation evaluation of poly (lactic acid) for stent application: Role of mechanical tension and temperature

Amnieh, Sasan Khalaj; Mosaddegh, Peiman; Mashayekhi, ‪Mohammadreza; Kharaziha, Mahshid

doi:10.1002/app.50389

Cited by 14 publications

(6 citation statements)

References 59 publications

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“…It is known that the primary factor of PLA degradation is hydrolysis, which is influenced by temperature conditions and results in the weakening of mechanical properties. [ 42 ] Nevertheless, as already shown in a previous work, [ 8,9 ] PET yarns are the primary providers of tensile strength for the produced hybrid braids and, consequently, for the final medical device. As such, the mechanical properties of the previously optimized hybrid braids are maintained after both treatments and can still fulfill the high mechanical demands of tissues such as tendons or ligaments.…”

Section: Resultsmentioning

confidence: 87%

Amination of Polymeric Braid Structures to Improve Tendon Healing: An Experimental Comparison

Peixoto

Silva

Rodrigues

et al. 2022

Macro Materials & Eng

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Several polymers are researched for tendon repair as polyethylene terephthalate (PET) and polylactic acid (PLA). These are biocompatible and useful in scaffolding repair though with minimal success due to long-term failure. There is a need to improve such scaffolds' design and physical-chemical nature. This work concerns surface functionalization of polymeric braids (PET and PLA) that fulfill the high mechanical demands of tissues such as tendons. The functionalization aims to incorporate amine groups in the braids' surface, improve cell adhesion, and consequently, the poor healing rate of these tissues and the biointegration of the braids. Two approaches are compared: the direct application of NH 3 plasma and the surface grafting of EDA after O 2 plasma activation. X-ray photoelectron spectroscopy (XPS) shows that amine groups are effectively introduced onto the samples' surfaces. Besides, the plasma parameters chosen do not compromise the topography and tensile behavior of the braids. Resazurin assay and scanning electron microscopy show that the NH 3 treatment improves cell-biomaterial interaction as improved cell adhesion and proliferation are observed. Both approaches are safe for biomedical applications. The NH 3 plasma approach is more environmentally friendly, faster, and easier to scale-up, showing potential for application in the final hybrid medical device.

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Section: Resultsmentioning

confidence: 87%

Amination of Polymeric Braid Structures to Improve Tendon Healing: An Experimental Comparison

Peixoto

Silva

Rodrigues

et al. 2022

Macro Materials & Eng

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“…The steps for stress relaxation testing are as follows: compress the test lumen from its original diameter of 9.5 mm to a diameter of 4 mm at a speed of 2.5mmÁmin À1 , hold for a certain amount of time, and then open the test lumen at the same speed so that stents recoils to the unloaded state. 26,34 Throughout the experiment, the axial length of stents does not exceed the length of the test lumen.…”

Section: Preparation Of Plla Braided Stentsmentioning

confidence: 99%

Evaluation of the stress relaxation behavior of poly (L‐lactic acid) self‐expanding braided stents

Cheng,

Zhao,

et al. 2023

Polymers for Advanced Techs

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Stress relaxation of poly (L‐lactic acid) (PLLA) braided stents generated after crimping will significantly influence the radial properties of the stents, due to the viscoelasticity of PLLA. In particular, the environmental temperature and duration in the relaxation process are two vital effects on these radial performances. Thereby, a serious of crimping temperatures and holding durations were adopted in this study to investigate their influence on the radial properties of stents. The radial properties of the stent, including peak compression force, chronic outward force and energy loss, were characterized by radial mechanical tests. Results showed that the stress relaxation rates of PLLA braided stents increased with the increase of the crimp‐holding temperature and time. Specifically, the stress relaxation rates at 25, 37 and 42°C were 22.81%, 28.41% and 36.10% at hold time of 300 s. Moreover, the increase of stress relaxation can reduce chronic outward force of stents, which will furtherly cause complications such as insufficient supporting and the shift of stent and so on. Therefore, decreasing the crimp‐holding temperature and duration of stents is an effective method to reduce the stent stress relaxation. This work provides experimental references for the comprehensive evaluation of mechanical properties of PLLA braided stent in clinical application.

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“…Poly(lactic acid) is considered as the best candidate for biomedical implant replacement due to its biodegradable and biocompatibility properties. Its degradation occurs through hydrolysis at molecular level whereby the breakage of backbone bonds occur by water penetration [36]. The degradation hydrolysis rate is affected by temperature conditions and stress imposed [36].…”

Section: Poly(lactic Acid) (Pla)mentioning

confidence: 99%

Biodegradable Polymeric Stent: Poly(lactic acid) Variation

Jumat,

Vangetaraman,

Ahmad Shafi

et al. 2023

HumEnTech

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Stenting is a treatment procedure to insert an implant-like needle into the blood vessel for the purpose of removing plaque and thrombosis while supporting the weak blood vessel. This procedure will enlarge the narrow blood vessel and restore blood circulation. Specifically, stent implantation is being combined with coronary angioplasty procedure to be known as percutaneous coronary intervention (PCI), which is an approach to treat cardiovascular diseases (CVD). There are three main variations of commercialized stents: Bare metal stent, drug-eluting stent and biodegradable stent. These three variations are focusing on the utilization of metal as the base material. Biodegradable metallic stent is a metallic stent which can be degraded into the physiological environment following an implantation. Even though forthcoming complications of permanent stent can be overcome with this type of stent, the degradation products often trigger inflammation and disturb the cascaded physiological processes. Therefore, researchers are moving towards biodegradable polymeric stents that are able to degrade while not harming the implanted lesion and surrounding tissues. This review article is intended to expose the information on biodegradable polymeric stent specifically to the implementation of poly(lactic acid) (PLA) and its variation as the polymeric materials.

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Biodegradation evaluation of poly (lactic acid) for stent application: Role of mechanical tension and temperature

Cited by 14 publications

References 59 publications

Amination of Polymeric Braid Structures to Improve Tendon Healing: An Experimental Comparison

Amination of Polymeric Braid Structures to Improve Tendon Healing: An Experimental Comparison

Evaluation of the stress relaxation behavior of poly (L‐lactic acid) self‐expanding braided stents

Biodegradable Polymeric Stent: Poly(lactic acid) Variation

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