Biodegradation of Carbon Nanotubes by Macrophages

Yang, Mei; Zhang, Minfang

doi:10.3389/fmats.2019.00225

Cited by 63 publications

(40 citation statements)

References 71 publications

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“…Similar results have been documented several times in vitro when sp 2 -hybridized carbon nanomaterials, including GBMs, were exposed to oxidizing chemicals, 19 peroxidase family enzymes, 17 , 18 , 23 and other enzymes such as cellular nicotinamide adenine dinucleotide phosphate-oxidase (NADPH oxidase) or induced nitrogen oxide synthase (iNOS). 92 In terms of a possible mechanism by which the GO sheets were being biodegraded intracellularly, based on the extensive work concerning CNT degradation in macrophages, 93 it can be envisioned that following phagocytosis in MZMs membrane-bound NADPH oxidase was activated and catalyzed the production of superoxide. Superoxide dismutase could then convert the superoxide into hydrogen peroxide, which could react with free radical nitric oxide to generate reactive peroxynitrite.…”

Section: Go Sheets Biodegrade In the Marginal Zone Macrophages Over Nmentioning

confidence: 99%

Splenic Capture and In Vivo Intracellular Biodegradation of Biological-Grade Graphene Oxide Sheets

et al. 2020

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Carbon nanomaterials, including 2D graphene-based materials, have shown promising applicability to drug delivery, tissue engineering, diagnostics, and various other biomedical areas. However, to exploit the benefits of these materials in some of the areas mentioned, it is necessary to understand their possible toxicological implications and long-term fate in vivo . We previously demonstrated that following intravenous administration, 2D graphene oxide (GO) nanosheets were largely excreted via the kidneys; however, a small but significant portion of the material was sequestered in the spleen. Herein, we interrogate the potential consequences of this accumulation and the fate of the spleen-residing GO over a period of nine months. We show that our thoroughly characterized GO materials are not associated with any detectable pathological consequences in the spleen. Using confocal Raman mapping of tissue sections, we determine the sub-organ biodistribution of GO at various time points after administration. The cells largely responsible for taking up the material are confirmed using immunohistochemistry coupled with Raman spectroscopy, and transmission electron microscopy (TEM). This combination of techniques identified cells of the splenic marginal zone as the main site of GO bioaccumulation. In addition, through analyses using both bright-field TEM coupled with electron diffraction and Raman spectroscopy, we reveal direct evidence of in vivo intracellular biodegradation of GO sheets with ultrastructural precision. This work offers critical information about biological processing and degradation of thin GO sheets by normal mammalian tissue, indicating that further development and exploitation of GO in biomedicine would be possible.

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Section: Go Sheets Biodegrade In the Marginal Zone Macrophages Over Nmentioning

confidence: 99%

Splenic Capture and In Vivo Intracellular Biodegradation of Biological-Grade Graphene Oxide Sheets

et al. 2020

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“…The history of nanotubes [1,2] and fullerenes [3] spans several decades; the most important stages in understanding of their nature and properties are well represented in recent reviews and books [4][5][6][7][8][9][10]. The main directions of practical application of such nanoobjects are connected with creation of new materials [4,[7][8][9][10][11][12][13][14], applications in pharmacy and medicine [15][16][17][18][19][20][21][22][23][24] and wastewater treatment [25]. These possibilities resulted mainly from the formation of endohedral complexes of fullerenes and nanotubes; the first example, synthesis of lanthanum complexes of C 60 , was described in [26].…”

Section: Introductionmentioning

confidence: 99%

Stereochemistry of Simple Molecules inside Nanotubes and Fullerenes: Unusual Behavior of Usual Systems

Кузнецов

2020

Molecules

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Over the past three decades, carbon nanotubes and fullerenes have become remarkable objects for starting the implementation of new models and technologies in different branches of science. To a great extent, this is defined by the unique electronic and spatial properties of nanocavities due to the ramified π-electron systems. This provides an opportunity for the formation of endohedral complexes containing non-covalently bonded atoms or molecules inside fullerenes and nanotubes. The guest species are exposed to the force field of the nanocavity, which can be described as a combination of electronic and steric requirements. Its action significantly changes conformational properties of even relatively simple molecules, including ethane and its analogs, as well as compounds with C−O, C−S, B−B, B−O, B−N, N−N, Al−Al, Si−Si and Ge−Ge bonds. Besides that, the cavity of the host molecule dramatically alters the stereochemical characteristics of cyclic and heterocyclic systems, affects the energy of pyramidal nitrogen inversion in amines, changes the relative stability of cis and trans isomers and, in the case of chiral nanotubes, strongly influences the properties of R- and S-enantiomers. The present review aims at primary compilation of such unusual stereochemical effects and initial evaluation of the nature of the force field inside nanotubes and fullerenes.

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“…[24] CNTs can be degraded by peroxidases as well as by neutrophils and macrophages, although complete biodegradation in the body was not demonstrated yet. [184][185][186] Both CNTs and the graphene family nanomaterials have also demonstrated some potential for regenerative medicine and tissue engineering. [187][188][189] The intrinsic fluorescent properties of NDs with high photostability may be exploited further for biomedical imaging and clinical diagnosis.…”

Section: Clinical Translation Of Carbon Nanomaterialsmentioning

confidence: 99%

Carbon Nanomaterials Applied for the Treatment of Inflammatory Diseases: Preclinical Evidence

Soltani

Guo

Bianco

et al. 2020

Advanced Therapeutics

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In the last decade, graphene‐based nanomaterials and carbon dots have joined the family of carbon materials mainly composed of graphite, diamond, fullerene, and carbon nanotubes. Carbon nanomaterials have been widely exploited in various fields from electronics and materials science to nanomedicine. The studies on their effect on the immune system have revealed that they possess intrinsic anti‐inflammatory properties, reducing the production of proinflammatory cytokines and modulating immune cell maturation. In addition, their large specific surface area associated with high biocompatibility allows their use as carriers for the delivery of anti‐inflammatory agents. They can also contribute to the diagnosis of inflammatory diseases as biosensors for low‐limit detection and quantification of inflammation‐related biomarkers in body fluids and tissues allowing to monitor the concentration of drugs in urine and guide personalized drug usage. Finally, they are used as adsorbents for blood plasma purification in the clinical treatment of sepsis through efficient removal of certain cytokines. This review focuses on the intrinsic anti‐inflammatory properties of carbon nanomaterials. An overview is provided on their use as carriers of anti‐inflammatory drugs, as biosensors, and for blood purification in the context of inflammatory diseases. The potential of carbon nanomaterials for clinical translation is also critically discussed.

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Biodegradation of Carbon Nanotubes by Macrophages

Cited by 63 publications

References 71 publications

Splenic Capture and In Vivo Intracellular Biodegradation of Biological-Grade Graphene Oxide Sheets

Splenic Capture and In Vivo Intracellular Biodegradation of Biological-Grade Graphene Oxide Sheets

Stereochemistry of Simple Molecules inside Nanotubes and Fullerenes: Unusual Behavior of Usual Systems

Carbon Nanomaterials Applied for the Treatment of Inflammatory Diseases: Preclinical Evidence

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