The paper deals with manned orbital station-hotels built for regular visits of space tourists. The purpose of the study was to find a rational method to dispose waste products from the orbital station operation. For three options of the crew number, we introduce four ways to dispose waste products from tourists --- residents of the near-еarth and near-lunar orbital station-hotels. During the study, we used a system analysis method and developed a mathematical model of the manned space infrastructure. We estimated the effect of each method on economic costs in the design, manufacture and operation of the orbital stations and carried out a comparative analysis of the possible methods of waste disposal. Based on the results obtained, we propose rational options for both orbital stations. As a criterion of rationality, we chose indicators of program costs and unit costs for one visit by one tourist.