Biodegradation of metformin and guanylurea by aerobic cultures enriched from sludge

Briones, Rowena M.; Zhuang, Wei-Qin; Sarmah, Ajit K.

doi:10.1016/j.envpol.2018.08.075

Cited by 34 publications

(19 citation statements)

References 14 publications

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“…The inoculum from AMS was also able to remove GUA in chemostat after 70 days of incubation. Very few studies reported the biodegradation of both MET and GUA 29,31 in batch or chemostat systems. The catabolic pathway leading to the consumption of GUA is unknown but microbial communities are suspected to use MET and GUA as alternative nitrogen sources under nitrogen limited condition.…”

Section: Exposure Treatmentsmentioning

confidence: 99%

“…The catabolic pathway leading to the consumption of GUA is unknown but microbial communities are suspected to use MET and GUA as alternative nitrogen sources under nitrogen limited condition. 31 Finally, bacteria from the genus Aminobacter were shown to be involved in the transformation of MET to GUA. 29 However, in depth investigation of the inocula composition could not correlate the abundance of Aminobacter related bacteria with the biodegradation level of MET, which means that other members of the community must be responsible for the biodegradation of MET in this experiment.…”

Section: Exposure Treatmentsmentioning

confidence: 99%

“…MET is biotransformed into a metabolite, guanylurea (GUA), which is thought to be even more environmentally persistent, 27 while recent studies succeed to degrade this product under laboratory conditions. 29,31 4CA is a building block used in the synthesis of pesticides, pharmaceuticals and dyes. It is also an intermediate produced of the microbial transformation of chlorinated pesticides and has been detected in the aquatic environment and wastewater.…”

Section: Introductionmentioning

confidence: 99%

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Influence of short- and long-term exposure on the biodegradation capacity of activated sludge microbial communities in ready biodegradability tests

Dalmijn

Poursat

Spanning

et al. 2021

Environ. Sci.: Water Res. Technol.

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Section: Exposure Treatmentsmentioning

confidence: 99%

Section: Exposure Treatmentsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Influence of short- and long-term exposure on the biodegradation capacity of activated sludge microbial communities in ready biodegradability tests

Dalmijn

Poursat

Spanning

et al. 2021

Environ. Sci.: Water Res. Technol.

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“…Recent reports have indicated that there are also high concentrations of metformin in domestic wastewater treatment plants’ influent [12]. This is because it is excreted un-metabolized from the human body in urine and ends up in wastewater and aquatic environments [14]. Metformin is the pharmaceutical compound with the highest concentration in domestic wastewater (i.e., 64–98 µg/L) [15].…”

Section: Introductionmentioning

confidence: 99%

Treatment of Metformin-Containing Wastewater by a Hybrid Vertical Anaerobic Biofilm-Reactor (HyVAB)

Janka

Carvajal

Wang

et al. 2019

IJERPH

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Several series of batch and continuous experiments were performed to investigate the removal of metformin and other contaminants from two wastewaters: wastewater I (WWI) containing 4 mg/L metformin and wastewater II (WWII) containing 110 g/L butanol. Biomethane potential (BMP) tests on WWII showed 77% of total chemical oxygen demand (tCOD = 110 g/L) degradability, and no apparent inhibition effects were observed. BMP tests on WWI showed an apparent inhibitory effect reflected in lower biogas production with increasing metformin concentration in the wastewater. Continuous flow hybrid vertical anaerobic biofilm (HyVAB®) experiments were consistent with the batch test findings. It was necessary to co-digest WWI (metformin) with WWII (easily degradable organics) to achieve complete metformin removal. After a period of adaptation, WWI and WWII co-digestion achieved up to 98% tCOD removal and 100% metformin removal. Most of the contaminants were removed in the anaerobic section of the HyVAB®, which implies that higher chemical oxygen demand (COD) loads than tested here are possible, given some optimization. The pilot reactor was able to manage organic loads of 11 g COD/d and above 10 mg/L metformin with a removal of 98% and 100% for tCOD and metformin, respectively.

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“…Metformin was reported to get bio-transformed to its metabolite guanylurea 176 . Other report suggested the autocatalytic degradation behaviour of metformin, i.e., the degradation of metformin was rapidly increased by the presence of its metabolite guanyl-urea at particular concentration in the solution 177 . Also, guanyl-urea was reported to be degraded when glucose is provided as an energy and carbon source 177 .…”

Section: Fate Of Organic Mps In Wastewater Treatment Plantmentioning

confidence: 98%

Investigating the fate of organic micropollutants due to the dosing of iron salt or iron rich drinking water treatment sludge in urban wastewater system

Kulandaivelu¹

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Hydrogen sulfide production in the sewer network is the major cause for sewer corrosion and odour related issues. Iron (Fe) salt dosing is one of the efficient methods for sulfide control in the sewer network by precipitating the biologically formed sulfide to iron sulfide (FeS) particles. Though Fe salt is efficient in controlling sulfide, it requires continuous dosing that necessitates the search for alternative cheap sources.Meanwhile, water utilities are seeking an efficient management strategy for the discharge of sludge by-product from the drinking water treatment process. This byproduct also known as drinking water treatment sludge (DWTS) is either Fe-rich or aluminium (Al)-rich based on the coagulant used. The high Fe content in Fe-DWTS, could potentially be used to replace Fe salts for sulfide control in the sewer network.During Fe salt/Fe-DWTS dosing, formation of FeS particles is considered as the major sulfide control mechanism in the sewer network. Previous studies explored the multiple benefits of upstream sewer Fe dosing in the downstream processes such as phosphates removal in the bioreactor and sulfide mitigation in the anaerobic digester of the receiving wastewater treatment plant (WWTP). However, it is also well known that Fe salt is an effective coagulant for organic micropollutants (MPs) removal in the water treatment processes. As organic MPs such as pharmaceuticals, licit and illicit drugs, food additives etc., are ubiquitous in wastewater, the impact of dosing Fe salt/Fe-DWTS in the sewer network on the fate of these MPs is important but largely unknown. This thesis aims to address this research gap by investigating the impact of upstream Fe salt/Fe-DWTS dosing in sewers on the fate of organic MPs in the downstream sewer network and treatment process.Firstly, the impact of Fe salt dosing on the fate of selected organic MPs (8 compounds) was studied in a lab-scale rising main sewer reactor. The sulfide produced by sewer biofilms reacted with Fe 3+ forming black coloured FeS. Among the selected MPs, morphine, methadone and atenolol had >90% initial rapid removal within 5 min of Fedosing in the sewer reactor. The ultimate removal after 6 hr of retention time in the reactor reached 93-97%. Other compounds, ketamine, codeine, carbamazepine and acesulfame had 30-70% decrease of aqueous concentrations. The ultimate removal varied between 35 and 70% depending on their biodegradability. In contrast, paracetamol had no initial removal. Adsorption to the surface of FeS particles was likely responsible for the rapid MPs removal. viii Contribution by others to the thesisThis thesis contains some significant and substantial contribution from others as described below.

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Biodegradation of metformin and guanylurea by aerobic cultures enriched from sludge

Cited by 34 publications

References 14 publications

Influence of short- and long-term exposure on the biodegradation capacity of activated sludge microbial communities in ready biodegradability tests

Influence of short- and long-term exposure on the biodegradation capacity of activated sludge microbial communities in ready biodegradability tests

Treatment of Metformin-Containing Wastewater by a Hybrid Vertical Anaerobic Biofilm-Reactor (HyVAB)

Investigating the fate of organic micropollutants due to the dosing of iron salt or iron rich drinking water treatment sludge in urban wastewater system

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