Biodegradation of Poly(aspartamide) Based Hydrogels

Juriga, Dávid; Zrı́nyi, Miklós

doi:10.1002/masy.201800194

Cited by 2 publications

(1 citation statement)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For PASPAm derivatives that respond to stimuli, the degradation site and behavior are more diverse. For instance, Juriga et al [119,120] investigated the degradability of cross-linked PASPAm hydrogels containing disulfide linkages with different enzymes (trypsin-EDTA, dispase and collagenase I). Collagenase I showed the best effect for the degradation of hydrogel disk, followed by trypsin-EDTA and then dispase, because collagenase I cleaved the disulfide linkages in the hydrogel.…”

Section: Degradationmentioning

confidence: 99%

Stimuli-Responsive Poly(aspartamide) Derivatives and Their Applications as Drug Carriers

Zhang

Bao

2021

IJMS

View full text Add to dashboard Cite

Poly(aspartamide) derivatives, one kind of amino acid-based polymers with excellent biocompatibility and biodegradability, meet the key requirements for application in various areas of biomedicine. Poly(aspartamide) derivatives with stimuli-responsiveness can usually respond to external stimuli to change their chemical or physical properties. Using external stimuli such as temperature and pH as switches, these smart poly(aspartamide) derivatives can be used for convenient drug loading and controlled release. Here, we review the synthesis strategies for preparing these stimuli-responsive poly(aspartamide) derivatives and the latest developments in their applications as drug carriers.

show abstract

Section: Degradationmentioning

confidence: 99%

Stimuli-Responsive Poly(aspartamide) Derivatives and Their Applications as Drug Carriers

Zhang

Bao

2021

IJMS

View full text Add to dashboard Cite

show abstract

Poly(aspartic acid) in Biomedical Applications: From Polymerization, Modification, Properties, Degradation, and Biocompatibility to Applications

Adelnia

Tran

Little

et al. 2021

ACS Biomater. Sci. Eng.

View full text Add to dashboard Cite

Poly(aspartic acid) (PASP) is an anionic polypeptide that is a highly versatile, biocompatible, and biodegradable polymer that fulfils key requirements for use in a wide variety of biomedical applications. The derivatives of PASP can be readily tailored via the amine-reactive precursor, poly(succinimide) (PSI), which opens up a large window of opportunity for the design and development of novel biomaterials. PASP also has a strong affinity with calcium ions, resulting in complexation, which has been exploited for bone targeting and biomineralization. In addition, recent studies have further verified the biocompatibility and biodegradability of PASP-based polymers, which is attributed to their protein-like structure. In light of growing interest in PASP and its derivatives, this paper presents a comprehensive review on their synthesis, characterization, modification, biodegradation, biocompatibility, and applications in biomedical areas.

show abstract

Biodegradation of Poly(aspartamide) Based Hydrogels

Cited by 2 publications

References 15 publications

Stimuli-Responsive Poly(aspartamide) Derivatives and Their Applications as Drug Carriers

Stimuli-Responsive Poly(aspartamide) Derivatives and Their Applications as Drug Carriers

Poly(aspartic acid) in Biomedical Applications: From Polymerization, Modification, Properties, Degradation, and Biocompatibility to Applications

Contact Info

Product

Resources

About