Biodegradation of Silk Biomaterials

Cao, Yang; Wang, Bochu

doi:10.3390/ijms10041514

Cited by 586 publications

(470 citation statements)

References 52 publications

Supporting

Mentioning

459

Contrasting

Unclassified

Order By: Relevance

“…These results demonstrated that the overall enzymatic degradation of the silk component was mediated by surface erosion. [41] To evaluate the effect of enzyme exposure, the electrical resistance was monitored during the incubation period in buffered protease XIV solution or PBS as controls (Figure 8a). The sheet resistivity increased from 0.6 to ~5.4 kΩ sq -1 upon 10 days exposure to the enzyme solution, roughly 9 times compared with its original value.…”

Section: Enzymatic Degradation Of Sf-ppy Filmmentioning

confidence: 99%

Toward Biodegradable Mg–Air Bioelectric Batteries Composed of Silk Fibroin–Polypyrrole Film

Jia

Wang

Zhao

et al. 2016

Adv Funct Materials

107

View full text Add to dashboard Cite

Biodegradable active implantable devices can be used to diagnose and/or treat disease and eventually disappear without surgical removal. If an "external" energy source is required for effective operation then a biocompatible and biodegradable battery would be ideal. In this study, a partially biodegradable Mg-air bioelectric battery (biobattery) is demonstrated using a silk fibroin-polypyrrole (SF-PPy) film cathode coupled with bioresorbable Mg alloy anode in phosphate buffered saline (PBS) electrolyte. PPy is chemically coated onto one side of the silk substrate. SF-PPy film shows a conductivity of ≈1.1 S cm−1 and a mild catalytic activity toward oxygen reduction. It degrades in a concentrated buffered protease XIV solution, with a weight loss of 82% after 15 d. The assembled Mg-air biobattery exhibits a discharge capacity up to 3.79 mA h cm−2 at a current of 10 μA cm−2 at room temperature, offering a specific energy density of ≈4.70 mW h cm−2. This novel partially biodegradable battery provides another step along the route to biodegradable batteries. Abstract:Biodegradable active implantable devices can be used to diagnose and/or treat disease and eventually disappear without surgical removal. If an "external" energy source is required for effective operation then a biocompatible and biodegradable battery would be ideal. In this study, a partially biodegradable Mg-air bioelectric battery (bio-battery) was demonstrated using a silk fibroin-polypyrrole (SF-PPy) film cathode coupled with bioresorbable Mg alloy anode in phosphate buffered saline (PBS) electrolyte. Polypyrrole (PPy) is chemically coated onto one side of the silk substrate. SF-PPy film shows a conductivity of ~1.1 S cm -1 and a mild catalytic activity towards oxygen reduction. It degrades in a concentrated buffered 2 protease XIV solution, with a weight loss of 82% after 15 days. The assembled Mg-air biobattery exhibit a discharge capacity up to 3.79 mA h cm -2 at a current of 10 µA cm -2 at room temperature, offering a specific energy density of ∼4.70 mW h cm -2 . This novel partially biodegradable battery provides another step along the route to biodegradable batteries.

show abstract

Section: Enzymatic Degradation Of Sf-ppy Filmmentioning

confidence: 99%

Toward Biodegradable Mg–Air Bioelectric Batteries Composed of Silk Fibroin–Polypyrrole Film

Jia

Wang

Zhao

et al. 2016

Adv Funct Materials

107

View full text Add to dashboard Cite

show abstract

“…Regarding the first assumption, it is known that amorphous regions are easily degraded due to better accessibility of degradation agents such as VOCs, water vapour, oxygen [9][10][11]50], unlike tightly packed crystalline regions. The second assumption has its consequences in the calculation of DP.…”

Section: Kinetics Of Degradationmentioning

confidence: 99%

“…Ordered crystalline regions making up about 60 % of the fibroin mass [6] are interspersed with amorphous regions located in the area of the light chain [7]. These regions are richer in the hydrophilic amino acids such as serine, threonine, arginine and lysine, which are more susceptible to degradation [8][9][10][11][12].…”

Section: Introductionmentioning

confidence: 99%

Evaluating the impact of different exogenous factors on silk textiles deterioration with use of size exclusion chromatography

et al. 2016

View full text Add to dashboard Cite

Size exclusion chromatography (SEC), especially coupled with multiple angle laser light scattering detector (MALLS) is a powerful tool in diagnostics of deterioration of historic and art objects to evaluate their condition. In this paper, SEC-UV-MALLS-DRI technique was applied to study degradation of silk fibroin samples (Bombyx mori) artificially aged under various conditions: in the presence of oxygen, in different amount of water vapour and in volatile organic products (VOCs), all at temperature of 90°C. Conditions were chosen in such a way that it mimicked real conditions of textiles' storing during exhibitions and in show cases. The influence of temperature, moisture and VOCs content on the state of silk textiles was examined with the use of size exclusion chromatography. Pseudo-zero-order Ekenstam equation was applied to study degradation rates of fibroin with use of the approximated values of DP of fibroin.

show abstract

“…An ideal biomaterial is one that is nonimmunogenic, biocompatible, and biodegradable, which can be functionalized with bioactive proteins and chemicals. In particular, biodegradability is one of the essential properties of the biomaterials [11]. It must be emphasized that the key factors in biomaterial usage are its biocompatibility, biofunctionality, and availability to a lesser extent.…”

Section: Historymentioning

confidence: 99%

Natural Products: A Minefield of Biomaterials

Ige

Umoru

Aribo

2012

ISRN Materials Science

157

View full text Add to dashboard Cite

The development of natural biomaterials is not regarded as a new area of science, but has existed for centuries. The use of natural products as a biomaterial is currently undergoing a renaissance in the biomedical field. The major limitations of natural biomaterials are due to the immunogenic response that can occur following implantation and the lot-to-lot variability in molecular structure associated with animal sourcing. The chemical stability and biocompatibility of natural products in the body greatly accounts for their utilization in recent times. The paper succinctly defines biomaterials in terms of natural products and also that natural products as materials in biomedical fields are considerably versatile and promising. The various types of natural products and forms of biomaterials are highlighted. Three main areas of applications of natural products as materials in medicine are described, namely, wound management products, drug delivery systems, and tissue engineering. This paper presents a brief history of natural products as biomaterials, various types of natural biomaterials, properties, demand and economic importance, and the area of application of natural biomaterials in recent times.

show abstract

Biodegradation of Silk Biomaterials

Cited by 586 publications

References 52 publications

Toward Biodegradable Mg–Air Bioelectric Batteries Composed of Silk Fibroin–Polypyrrole Film

Toward Biodegradable Mg–Air Bioelectric Batteries Composed of Silk Fibroin–Polypyrrole Film

Evaluating the impact of different exogenous factors on silk textiles deterioration with use of size exclusion chromatography

Natural Products: A Minefield of Biomaterials

Contact Info

Product

Resources

About