Biodegradation of the cross-linked cationic poly(amino acid) hydrogels by proteolytic enzymes

Polyion complex fiber and capsule formed by self-assembly of chitosan and gellan at solution interfaces

“…The results themselves are scientifically interesting and might offer some clues towards the understanding of biological counterion interaction such as blood and extracellular material systems, as well as understanding its biomimesis, which undoubtedly includes a protein and/or polysaccharide interaction process, together with biodegradation by microorganisms and enzymes 15,[30][31][32] involved in keeping both land and sea ecology clean.…”

Self‐assembling capsule and fiber formations of polyion complexes of chitosan and poly( α , L ‐glutamic acid)

“…Silman and Sela have summarized biological applications of poly (amino acid)s 22) . Furthermore, both poly(amino acid) and chitosan are biodegradable materials 12,[22][23][24] , which are important criterion in the future industrial applications. Thus, the PLG-chitosan PIC fiber look very promising in their diverse medical, agricultural, and fiber industrial applications.…”

Photoresponsive Peptide and Polypeptide Systems. 13. Photoinduced Cross-Linked Gel and Biodegradation Properties of Copoly(l-lysine) Containing ε-7-Coumaryloxyacetyl-l-lysine Residues

“…Table 2, poly[Lys 90-95 Lys(Cou) ] at 10-30% (w/v) exhibit the strong and expandable photo-cross-linked hydrogels, while the photo-cross-linked poly[LysLys-(Cou)] containing more than 33 mol % Lys(Cou) are fragile. Figure 4 shows the photographs of the photocross-linked copoly[Lys 95 Lys(Cou) 5 ] and copoly[Lys 90 -Lys(Cou) 10 ] gels, which were prepared from the 20% (w/ v) solutions upon being irradiated for 24 h in water. The extent of cross-linking among the coumarin moieties was estimated to be 27.8% in the case of photo-crosslinked copoly[Lys 95 Lys(Cou) 5 ] gels and to be 18.5% in the case of copoly[Lys 90 Lys(Cou) 10 ] gels from the Flory equation (assuming that is 0.35).…”

“…4,5 In the course of our studies on bioadhesive material science, 6 we have reported some characterstics of polyamino acid hydrogels such as swelling properties, anion adsorption capability, adhesion, and biodegradation by proteolytic enzymes and microbial organisms. [7][8][9][10][11][12] In this article, we describe first synthesis of utilized photochemical techniques for the development of an artificial three-dimensional matrix and preparation of the photo-cross-linked poly(L-lysine) hydrogels, 2, from water-soluble copoly[LysLys(Cou)], 1, containing -7-coumaryloxyacetyl-L-lysine [Lys(Cou)] residues. Into the cross-linked hydrogel matrixes many bioreactive materials can be incorporated.…”

“…[10][11][12] The present article describes secondarily the biodegradation characteristics and the possibility for its use as biodegradable materials of photo-cross-linked hydrogels, since polylysine and coumarin are nontoxic biomaterials.…”