Biodegradation of the major rabbit retinal gangliosides, studied in vivo

Holm, M.

doi:10.1016/0014-5793(77)80239-1

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Gangliosides I N Retinal Dystrophy1

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1980

1985

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Cited by 4 publications

(1 citation statement)

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“…Holm and coworkers found that the most abundant mammalian retinal ganglioside, GD3, differed from the other major retinal gangliosides in both structure and metabolic activity (Holm et al, 1972;Holm and Mansson, 1974u,b,c;Holm, 1977). Because of these differences, they suggested that the cellular localization of GD3 was different from that of the other retinal gangliosides.…”

Section: Gangliosides I N Retinal Dystrophymentioning

confidence: 99%

Retinal Gangliosides in RCS Mutant Rats

Seyfried

Miyazawa

et al. 1982

Journal of Neurochemistry

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The distribution of retinal gangliosides was studied in normal and mutant rats with retinal dystrophy at 30 and 180 days of age. The loss of photoreceptor cells in the retinal dystrophic RCS rats was not associated with a significant reduction in the relative distribution of any of the major retinal gangliosides. The loss of photoreceptors, however, caused a marked increase in total retinal ganglioside concentration. These findings suggest that photoreceptor cells contain a low concentration of gangliosides and that no major retinal ganglioside is localized or concentrated in these cells. The cellular localization and function of the most abundant retinal ganglioside, GD3, is discussed.

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Section: Gangliosides I N Retinal Dystrophymentioning

confidence: 99%