Biodegradation pathway of penicillins by β-lactamase encapsulated in metal-organic frameworks

Yang, Ling; Hu, Dehua; Liu, Hailing; Wang, Xiangfeng; Liu, Yuan; Xia, Qianshu; Deng, Suimin; Huang, Yun; Jin, Yuhao; Xie, Mengxia

doi:10.1016/j.jhazmat.2021.125549

Cited by 39 publications

(11 citation statements)

References 64 publications

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“…As the matured technology of enzyme immobilization exhibited its advantages in many facets, researchers have shifted their focus to other enzymes. , Such as thermostable S -adenosylmethionine synthetase (SAMS) was immobilized in nickel-based MOF (Ni-BDC) via one-pot synthesis and evaluated under high temperature and acid solutions . Kinase, another family of enzymes with pivotal roles in organisms, has also been surface attached in MIL-101-NH 2 together with a Fe nanoparticle .…”

Section: Mofs As Enzyme Supportersmentioning

confidence: 99%

Bioinspired Framework Catalysts: From Enzyme Immobilization to Biomimetic Catalysis

et al. 2023

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Enzymatic catalysis has fueled considerable interest from chemists due to its high efficiency and selectivity. However, the structural complexity and vulnerability hamper the application potentials of enzymes. Driven by the practical demand for chemical conversion, there is a long-sought quest for bioinspired catalysts reproducing and even surpassing the functions of natural enzymes. As nanoporous materials with high surface areas and crystallinity, metal−organic frameworks (MOFs) represent an exquisite case of how natural enzymes and their active sites are integrated into porous solids, affording bioinspired heterogeneous catalysts with superior stability and customizable structures. In this review, we comprehensively summarize the advances of bioinspired MOFs for catalysis, discuss the design principle of various MOF-based catalysts, such as MOF−enzyme composites and MOFs embedded with active sites, and explore the utility of these catalysts in different reactions. The advantages of MOFs as enzyme mimetics are also highlighted, including confinement, templating effects, and functionality, in comparison with homogeneous supramolecular catalysts. A perspective is provided to discuss potential solutions addressing current challenges in MOF catalysis.

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Section: Mofs As Enzyme Supportersmentioning

confidence: 99%

Bioinspired Framework Catalysts: From Enzyme Immobilization to Biomimetic Catalysis

et al. 2023

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“…As shown in Fig. 2c, the synthesized ZIF-8 and Fe 3 O 4 @ZIF-8@MBLs both exhibited typical I-type isotherms, 34,35,42 indicating the presence of a large number of microporous structures in these composites. The surface areas of ZIF-8 and Fe 3 O 4 @ZIF-8@MBLs were 935 m 2 g −1 and 838 m 2 g −1 , respectively, which illustrated that the encapsulation of MBLs slightly decreased the surface area of the ZIF-8.…”

Section: Preparation and Characterization Of Zif-8-based Compositesmentioning

confidence: 84%

“…4d and S2b-d †). 34 Within 1 h, the strongest apparent degradation effect was observed for MER, followed by PG and CEF. As for PG, however, the activity of ZIF-8 would be stronger compared to Fe 3 O 4 @ZIF-8@MBLs.…”

Section: Stability and Selectivitymentioning

confidence: 99%

Metallo-β-lactamases immobilized by magnetic zeolitic imidazolate frameworks-8 for degradation of β-lactam antibiotics in an aqueous environment

Wang,

Sun,

Zhao

et al. 2023

RSC Adv.

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“…In most recently, several research using βlactamase to realize penicillin biodegradation. Although it is exhibited high efficiency, the degradation pathway is relatively simple, and only achieve the hydroxylation of penicillin without further mineralization degradation [44,45]. Our present work was using light irradiation to stimulate the catalytic efficiency of whole cell of KDSPL-02 and also our work realized the mineralization degradation of penicillin.…”

Section: Pathway Analysis Of Penicillin G Biodegradation By Parococcu...mentioning

confidence: 91%

Assessment of the efficiency of synergistic photocatalysis on penicillin G biodegradation by whole cell Paracoccus sp

et al. 2021

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Background The Paracoccus sp. strain isolated from sludge was identified and evaluated for catalytic activity in the degradation of penicillin G. Results High degradation efficiency and synergistic catalytic effects of the whole cell and visible light without additional catalysts were observed. The key factors influencing the degradation and kinetics of penicillin G were investigated. The results showed the phenylacetic acid, which was produced during penicillin G biodegradation, exhibited stronger inhibiting effects on KDSPL-02. However, this effect was reduced by visible light irradiation without any additional photocatalyst; furthermore, the rate of penicillin G biodegradation was accelerated, reaching a 100% rate in 12 h at a penicillin G concentration of 1.2 g/L. Four key intermediates produced during penicillin G degradation were isolated and identified by LC–MS, 1H NMR, and 13C NMR. Enzymes involved in the PAA pathway were proposed from a genomic analysis of KDSPL-02. Conclusions These results provide a new method for bio-degrading of penicillin or other antibiotic pollutants using photoaccelerating biocatalysts with greater efficiency and more environmentally friendly conditions.

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Biodegradation pathway of penicillins by β-lactamase encapsulated in metal-organic frameworks

Cited by 39 publications

References 64 publications

Bioinspired Framework Catalysts: From Enzyme Immobilization to Biomimetic Catalysis

Bioinspired Framework Catalysts: From Enzyme Immobilization to Biomimetic Catalysis

Metallo-β-lactamases immobilized by magnetic zeolitic imidazolate frameworks-8 for degradation of β-lactam antibiotics in an aqueous environment

Assessment of the efficiency of synergistic photocatalysis on penicillin G biodegradation by whole cell Paracoccus sp

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