The research was conducted at the experimental field, Southwest University of Science and Technology in three experimental phases; (1) Field trials were carried out in a Randomized Complete Blocked Design. The chemical compounds, nitrogen, phosphorus and potassium concentrations (N: P: K; 24:8:8) were applied to the xikamai-18 cultivar. Stellaria medium grew more than ordinary chickweed with NPK treatment. (2) Glasshouse trials were carried out single fertilizer of N (blank, 0.062, 0.070, 0.78 and 0.086g plant -1 ); P (blank, 0.079, 0.089, 0.099 and 0.108g plant -1 ) and K (blank, 0.018, 0.020, 0.023 and 0.025g plant -1 ), and the results were shown the effect of N on shoot and root growth in wheat T3. Moreover, the same treatment was decreased in weed. The growth of shoot and root in wheat T2 was affected using P treatment and also same treatment was decreased in weed. K treatment was affected on the growth of shoot and root in wheat T3, and same treatment decreased weed. (3) The Clodinafop-propargyl 0.05; 0.1; 0.2 and 0.3%/100ml, and Starane applied at 0.025, 0.05, 0.1 and 0.2g/100ml concentration were applied for seed germination with same experiments. Herbicide Clodinafop-propargyl was affected more in T2, and herbicide Starane in T3 on weeds. The physiological (Length, number and diameter of shoot and root), and biochemical (POD) parameters were measured. POD enzyme showed more activity in N: P: K fertilizers in T-4. It showed that (Starane and fertilizer concentration (N, P, K) 3.91g/m 2 , 4.455g/m 2 and 1.155g/m 2 ) resulted in optimum wheat physiological growth.