Biodistribution and Biocompatibility of DMSA-Stabilized Maghemite Magnetic Nanoparticles in Nonhuman Primates (
            <i>Cebus</i>
            Spp.)

Monge-Fuentes, Victoria; Garcia, Mônica Pereira; Tavares, Maria Clotilde Henriques; Valois, Caroline R.A.; Lima, E.C.D.; Teixeira, Danilo Simonini; Morais, P.C.; Tomaz, Carlos; Azevedo, Ricardo Bentes

doi:10.2217/nnm.11.47

Cited by 32 publications

(37 citation statements)

References 60 publications

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“…This implies that MNP were transformed to other non-superparamagnetic iron forms that can be processed and partially removed by iron metabolic pathways. In contrast to results from studies in which other DMSA-coated nanoparticles were used [25], we observed no DMSA-MNP in kidney, which might be due to differences in the animal model and/or physical characteristics of the nanoparticles. In addition, biodistribution might depend not only on the physicochemical properties of this type of nanoparticle, but also on extrinsic factors such as MNP dose and the type of anesthetic used [54].…”

Section: Biodistribution and Biotransformation Of Dmsa-mnp In Murine contrasting

confidence: 99%

“…MNP biodistribution and toxicity in the body is the other main concern that arises from the increasingly widespread use of nanoparticles for biomedical applications. Several studies in animal models showed preferential accumulation of iron oxide MNP in spleen and liver, and to a lesser extent in other organs, depending on dosage and surface coating [21][22][23][24][25]. Other research showed that iron metabolism biochemical pathways can process iron oxide MNP [26,27].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Long term biotransformation and toxicity of dimercaptosuccinic acid-coated magnetic nanoparticles support their use in biomedical applications

Mejías

Gutiérrez

Salas

et al. 2013

Journal of Controlled Release

122

106

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Although iron oxide magnetic nanoparticles (MNP) have been proposed for numerous biomedical applications, little is known about their biotransformation and long-term toxicity in the body. Dimercaptosuccinic acid (DMSA)-coated magnetic nanoparticles have been proven efficient for in vivo drug delivery, but these results must nonetheless be sustained by comprehensive studies of long-term distribution, degradation and toxicity. We studied DMSA-coated magnetic nanoparticles effects in vitro on NCTC 1469 nonparenchymal hepatocytes, and analyzed their biodistribution and biotransformation in vivo in C57BL/6 mice. Our results indicate that DMSA-coated magnetic nanoparticles have little effect on cell viability, oxidative stress, cell cycle or apoptosis on NCTC 1469 cells in vitro. In vivo distribution and transformation was studied by alternating current magnetic susceptibility measurements, a technique that permits distinction of MNP from other iron species. Our results show that DMSA-coated MNP accumulate in spleen, liver and lung tissues for extended periods of time, in which nanoparticles undergo a process of conversion from superparamagnetic iron oxide nanoparticles to other nonsuperparamagnetic iron forms, with no significant signs of toxicity.

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Section: Biodistribution and Biotransformation Of Dmsa-mnp In Murine contrasting

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Long term biotransformation and toxicity of dimercaptosuccinic acid-coated magnetic nanoparticles support their use in biomedical applications

Mejías

Gutiérrez

Salas

et al. 2013

Journal of Controlled Release

122

106

View full text Add to dashboard Cite

show abstract

“…4, administration of dextran-coated Fe 3 O 4 (average diameter, 9.4 nm) caused free iron to be released and no damaged cells or any other kind of morphological alterations were reported in the tissues investigated (Lacava et al 2004). Similarly, Monge-Fuentes et al (2011) studied the biocompatibility of -Fe 2 O 3 (stabilized with DMSA; DMSA-MNPs) and reported that MNPs might be safe in non-human primates. DMSA-MNPs i.v.…”

Section: Livermentioning

confidence: 99%

Magnetic nanoparticles: an update of application for drug delivery and possible toxic effects

2011

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Magnetic nanoparticles (MNPs) represent a subclass within the overall category of nanomaterials and are widely used in many applications, particularly in the biomedical sciences such as targeted delivery of drugs or genes, in magnetic resonance imaging, and in hyperthermia (treating tumors with heat). Although the potential benefits of MNPs are considerable, there is a distinct need to identify any potential toxicity associated with these MNPs. The potential of MNPs in drug delivery stems from the intrinsic properties of the magnetic core combined with their drug loading capability and the biomedical properties of MNPs generated by different surface coatings. These surface modifications alter the particokinetics and toxicity of MNPs by changing protein-MNP or cell-MNP interactions. This review contains current advances in MNPs for drug delivery and their possible organ toxicities associated with disturbance in body iron homeostasis. The importance of protein-MNP interactions and various safety considerations relating to MNP exposure are also addressed.

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“…Meso-2,3-dimercaptosuccinic acid (DMSA) has been used for surface-functionalization of bare maghemite nanoparticles at increasing surface-grafting values, revealing a rich scenario of interparticle and intra-particle linking via disulfide bridges resulting from the oxidation of neighboring thiol groups [78]. The biodistribution and biocompatibility of DMSA-coated maghemite nanoparticles have been recently tested in non-human primates [79]. DMSA-coated magnetic nanoparticles were conjugated to amine-functionalized poly-ethylene glycol (PEG) and revealed reduced internalization in cancer cell lines and extended circulation time in in vivo assays [80].…”

Section: Nanoparticle-based Hyperthermiamentioning

confidence: 99%

Remote Hyperthermia, Drug Delivery and Thermometry: The Multifunctional Platform Provided by Nanoparticles

Qi¹,

Morais

2014

J Nanomed Nanotechno

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The huge demand for biocompatible, robust, accurate and noninvasive technology to assess the temperature of a biological targeted site for monitoring the hyperthermia effect brings the topic of remote thermometry to a very high level of interest. There are already promising research directions to fulfil such demand in the short term and a review of the achievements in this issue is certainly worth. This report offers an overview of the research regarding the most promising nanothermometers nowadays, with emphasis on those addressed to remote operation while using optical or magnetic responses of nanosized materials as the thermometric property. More specifically the optical emission intensity, optical emission peak shift and optical emission lifetime will be covered as far as the optical-based nanothermometers are concerned. Additionally, for the magnetic-based nanothermometers the magnetization or the magnetic susceptibility are the thermometric properties covered in this review. Furthermore, the review includes the hyperthermia effect based on nanosized metallic or magnetic particles plus a couple of thermally-responsive polymeric drug delivery systems, aiming to provide an integrated view of the multipurpose platform offered by actuating-sensing nanoparticles. As far as the regulatory system is concerned the availability of noninvasive thermometry incorporating biocompatibility, robustness and accuracy will establish the grounds needed for the approval of the hyperthermia technology for therapeutic purposes, thus allowing the market of this technological option on a global scale.hyperthermia and thermoresponsive drug delivery systems for clinical use.Although nanothermometry is at its infancy considerable progress has been made recently in regard to its use for remote assessing the temperature at the site the nanomaterials are incorporated to. Nanoprobes allowing remote temperature-sensing using optical or magnetic properties are among the most promising directions nowadays. Most of the optical-based nanothermometers use the light-emitting intensity [15][16][17][18][19][20][21][22][23], light-emitting peak shift [24][25][26], or lifetime decay of a suitable optical band as the thermometric property [27][28][29][30]. As far as the clinical use is concerned the drawbacks of the actual optical-based nanothermometers rely on biocompatibility (usual semiconductor-based core nanoprobes or dye-based shell moieties are toxic), robustness (typical bleaching of organic-based shell moieties) or temperature accuracy (no better than 0.3°C nowadays), or even combination of these factors. Moreover, due to limitations imposed by living tissues on the optical penetration of light (optical therapeutic window in the 700-1100 nm wavelength range), noninvasive clinical use of optical excitation and signal pickup is a huge challenge, not yet solved, except for very special therapeutic applications, as for instance the photodynamic therapy for treatment (heating monitoring) of skin cancer and follow up [31]. Alternatively, ...

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Biodistribution and Biocompatibility of DMSA-Stabilized Maghemite Magnetic Nanoparticles in Nonhuman Primates ( Cebus Spp.)

Abstract: DMSA-MNPs were preferentially distributed to the lung, liver and kidneys. Furthermore, DMSA-MNPs were considered biocompatible, supporting their application as a promising nanomaterial platform for future biomedical use.

Cited by 32 publications

References 60 publications

Long term biotransformation and toxicity of dimercaptosuccinic acid-coated magnetic nanoparticles support their use in biomedical applications

Long term biotransformation and toxicity of dimercaptosuccinic acid-coated magnetic nanoparticles support their use in biomedical applications

Magnetic nanoparticles: an update of application for drug delivery and possible toxic effects

Remote Hyperthermia, Drug Delivery and Thermometry: The Multifunctional Platform Provided by Nanoparticles

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