Biodistribution and Pharmacokinetic Studies of SPION Using Particle Electron Paramagnetic Resonance, MRI and ICP-MS

Abstract

The results indicate that pEPR can be used to detect SPIONs in both preclinical and clinical studies.

Pharmacokinetics and bio‐distribution of novel super paramagnetic iron oxide nanoparticles (SPIONs) in the anaesthetized pig

“…The biodistribution of two dimercaptosuccinic acid (DMSA) coated magnetite (Fe 3 O 4 ) nanoparticles, MF66 (12 nm nominal core diameter) and OD15 (15 nm nominal core diameter) nanoparticles, were investigated. MF66 nanoparticles were produced in aqueous solvents (Liquid Research, Bangor, Wales) and OD15 (CSIC, Madrid, Spain) was synthesised via an organic route, as previously described …”

“…MF66 nanoparticles were produced in aqueous solvents (Liquid Research, Bangor, Wales) and OD15 (CSIC, Madrid, Spain) was synthesised via an organic route, as previously described. 8,9 Surgery and instrumentation Twenty-one female landrace pigs (20-25 kg) were sedated with ketamine (14.0 mg/kg) and xylazine (2.7 mg/kg) intra muscularly (i.m.). A cannula was inserted into an ear vein and the animal was anaesthetized with a bolus, followed by a continuous infusion of sodium pentobarbital (induction 30.0 mg/kg; maintenance 6 mg/kg/h i.v.).…”

Real-time liver uptake and biodistribution of magnetic nanoparticles determined by AC biosusceptometry

“…[50][51][52][53] The ESR spectra depend on the free-electron spin concentration and environment, which are material-dependent. 20 In the present study, we acquired MNP concentrations by measuring the area under the curve for the intensity absorption spectrum (centered in g = 2), which is related to the amount of resonant spins in the sample and thus related to the MNP concentration. 20,22,[50][51][52] All of the biodistribution samples were first evaluated by the ACB system and then analyzed by a JEOL ESR -X band spectrometer (JES -FA 200[9.5GHz]) under the same conditions and same parameters (temperature, 18°C; microwave power, 0.998 mW; microwave frequency, 9450.051 MHz; field range, 186-486 mT, centered in 336 mT; modulation amplitude, 0.2 mT; time constant, 0.03 s; 10× gain for heart and kidneys samples [for which we expected a lower MNP accumulation profile] and 5× gain for all other organs).…”

The Nanopharmacology and Nanotoxicology of Nanomaterials: New Opportunities and Challenges

“…For cancer treatment, nanotheranostic platforms can provide advanced diagnostics, hyperthermia treatment and targeted delivery of anticancer drugs [13]; superparamagnetic iron oxide nanoparticles (SPIONs) are an example of such platforms [14,15]. SPIONs have also been developed as a part of the MULTIFUN EU consortium (http://www.multifun-project.eu/) [16] and offer distinct advantages over other drug delivery platforms used with anticancer medications: a) the pharmacokinetics of SPIONs are easily determined using non-invasive imaging techniques such as nuclear magnetic resonance (NMR); b) SPIONs can easily be guided to cancer tissues using the electromagnetic field (EM); c) SPIONs can selectively generate energy to destroy cancer cells; and d) when functionalized with antibodies against cancer biomarkers, SPIONs can selectively deliver a "cocktail" of therapeutic pharmaceuticals (Fig. 1a).…”