Biodistribution and Pharmacokinetic Study of Gemcitabine Hydrochloride Loaded Biocompatible Iron-Based Metal Organic Framework

Kush, Preeti; Bajaj, Tania; Kaur, Manjot; Madan, Jitender; Jain, Upendra Kumar; Kumar, Parveen; Deep, Akash; Kim, Ki‐Hyun

doi:10.1007/s10904-019-01417-4

Cited by 27 publications

(15 citation statements)

References 47 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Human liver microsomes were used to determine the systemic stability of MFU. We found that MFU was very stable both in vitro and in human liver microsomal studies with more than 80% remaining intact after 2h, suggestive that it is more stable compared to GemHCl as reported in literature 8, [19][20][21]23,24 .…”

Section: Discussionsupporting

confidence: 79%

“…There was no statistically signi cant difference in the initial concentration of MFU after 24 h in both cell lines. This could mean that MFU is quite stable in vitro, and its activities seems to be longer than that GemHCl whose concentration falls to less than half initial concentration between 32 to 94 minutes as documented in literature [19][20][21] .…”

Section: Mfu Stabilitymentioning

confidence: 97%

See 1 more Smart Citation

Synthesis, characterization, and in vitro anticancer evaluation of 1,3-bistetrahydrofuran- 2yl-5-FU as a potential agent for pancreatic cancer

Ndemazie

Inkoom

Ebesoh

et al. 2022

Preprint

View full text Add to dashboard Cite

The failure of current chemotherapeutic agents for pancreatic cancer (PCa) makes it the most aggressive soft tissue tumor with a 5-year survival of slightly above 10% and is estimated to be the second leading cause of cancer death by 2030. Objective: The main aim was to synthesize, characterize and evaluate the in-vitro anticancer activity of 1,3-bistetrahydrofuran-2yl-5FU (MFU). Methods: MFU was synthesized by using 5-fluorouracil (5-FU) and tetrahydrofuran acetate, and characterized by nuclear magnetic resonance (NMR), micro-elemental analysis, high-performance liquid chromatography (HPLC), and liquid chromatography with mass spectrophotometry (LC-MS). MFU and Gemcitabine hydrochloride (GemHCl) were tested for antiproliferative activity against MiaPaca-2 and Panc-1 cell lines. Results: The half-minimum inhibitory concentration (IC50) of MFU was twice lower than that of GemHCl when used in both cell lines. MiaPaca-2 cells (MFU-IC50 =4.5±1.2μM vs. GemHCl-IC50=10.3±1.1μM); meanwhile similar trend was observed in Panc-1 cells (MFU-IC50=3.0 ±1μM vs. GemHCl-IC50=6.1±1.03μM). The MFU and GemHCl effects on 3D spheroids showed a similar trend (IC50-GemHCl=14.3±1.1μM vs. IC50-MFU =7.2±1.1μM) for MiaPaca-2 cells, and (IC50-GemHCl=16.3±1.1μM vs. IC50-MFU=9.2±1.1μM) for Panc-1 cells. MFU significantly inhibited clonogenic cell growth, and induced cell death via apoptosis. Cell cycle data showed mean PI for GemHCl (48.5 - 55.7) twice higher than MFU (24.7 to 27.9) for MiaPaca-2 cells, and similarly to Panc-1 cells. The in-vivo model showed intensely stained EGFR (stained brown) in all mice tumors, however, HER2 expression was less stained in MFU-treated tumors compared to GemHCl-treated tumors and controls. Conclusion: MFU was synthesized with high purity and may have potential anticancer activity against Pca.

show abstract

Section: Discussionsupporting

confidence: 79%

Section: Mfu Stabilitymentioning

confidence: 97%

Synthesis, characterization, and in vitro anticancer evaluation of 1,3-bistetrahydrofuran- 2yl-5-FU as a potential agent for pancreatic cancer

Ndemazie

Inkoom

Ebesoh

et al. 2022

Preprint

View full text Add to dashboard Cite

show abstract

“…Moreover, latest study show that the bioavailability and therapeutic efficacy of GEM encapsulated in the MIL-100(Fe) were improved in comparation to the GEM 276 . In this study, the Wistar rats were given i.v.…”

Section: Biopharmaceutics Of Mofs and Mofs-based Ddssmentioning

confidence: 99%

Metal-organic frameworks for advanced drug delivery

et al. 2021

Acta Pharmaceutica Sinica B

293

116

View full text Add to dashboard Cite

Metal-organic frameworks (MOFs), comprised of organic ligands and metal ions/metal clusters via coordinative bonds are highly porous, crystalline materials. Their tunable porosity, chemical composition, size and shape, and easy surface functionalization make this large family more and more popular for drug delivery. There is a growing interest over the last decades in the design of engineered MOFs with controlled sizes for a variety of biomedical applications. This article presents an overall review and perspectives of MOFs-based drug delivery systems (DDSs), starting with the MOFs classification adapted for DDSs based on the types of constituting metals and ligands. Then, the synthesis and characterization of MOFs for DDSs are developed, followed by the drug loading strategies, applications, biopharmaceutics and quality control. Importantly, a variety of representative applications of MOFs are detailed from a point of view of applications in pharmaceutics, diseases therapy and advanced DDSs. In particular, the biopharmaceutics and quality control of MOFs-based DDSs are summarized with critical issues to be addressed. Finally, challenges in MOFs development for DDSs are discussed, such as biostability, biosafety, biopharmaceutics and nomenclature.

show abstract

“…To investigate MOF toxicity many factors must be considered. The toxicity of the metal and linker play a crucial role, however, particle size effects, colloidal stability, aggregation, biodistribution, accumulation and metabolism greatly affect toxicity [ 256 , 257 ]. To date, in vivo and in vitro studies have only been carried out on a small number of MOFs, mainly those containing small carboxylate linkers.…”

Section: Discussionmentioning

confidence: 99%

Synthesis and Biomedical Applications of Highly Porous Metal–Organic Frameworks

Ahmed

McHugh

Papatriantafyllopoulou

2022

Molecules

View full text Add to dashboard Cite

In this review, aspects of the synthesis, framework topologies, and biomedical applications of highly porous metal–organic frameworks are discussed. The term “highly porous metal–organic frameworks” (HPMOFs) is used to denote MOFs with a surface area larger than 4000 m2 g−1. Such compounds are suitable for the encapsulation of a variety of large guest molecules, ranging from organic dyes to drugs and proteins, and hence they can address major contemporary challenges in the environmental and biomedical field. Numerous synthetic approaches towards HPMOFs have been developed and discussed herein. Attempts are made to categorise the most successful synthetic strategies; however, these are often not independent from each other, and a combination of different parameters is required to be thoroughly considered for the synthesis of stable HPMOFs. The majority of the HPMOFs in this review are of special interest not only because of their high porosity and fascinating structures, but also due to their capability to encapsulate and deliver drugs, proteins, enzymes, genes, or cells; hence, they are excellent candidates in biomedical applications that involve drug delivery, enzyme immobilisation, gene targeting, etc. The encapsulation strategies are described, and the MOFs are categorised according to the type of biomolecule they are able to encapsulate. The research field of HPMOFs has witnessed tremendous development recently. Their intriguing features and potential applications attract researchers’ interest and promise an auspicious future for this class of highly porous materials.

show abstract

Biodistribution and Pharmacokinetic Study of Gemcitabine Hydrochloride Loaded Biocompatible Iron-Based Metal Organic Framework

Cited by 27 publications

References 47 publications

Synthesis, characterization, and in vitro anticancer evaluation of 1,3-bistetrahydrofuran- 2yl-5-FU as a potential agent for pancreatic cancer

Synthesis, characterization, and in vitro anticancer evaluation of 1,3-bistetrahydrofuran- 2yl-5-FU as a potential agent for pancreatic cancer

Metal-organic frameworks for advanced drug delivery

Synthesis and Biomedical Applications of Highly Porous Metal–Organic Frameworks

Contact Info

Product

Resources

About