Biodistribution and Pharmacokinetics of Antimicrobials

Ordoñez, Alvaro A.; Bambarger, Lauren E.; Jain, Sanjay; Weinstein, Edwin A.

doi:10.1007/978-3-319-54592-9_10

Cited by 7 publications

(7 citation statements)

References 74 publications

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“…Radiolabeled antibiotics and PET imaging also provide a noninvasive technique for studying pharmacokinetics and pharmacodynamics in vivo . 106–110 A large number of antibiotics have been radiolabeled, with 99m Tc being the predominant radionuclide since the tracer preparation is easily accomplished using a cold kit format within 30 minutes. 111–113 However, a large number of these radiolabeled antibiotics have not been able to differentiate infection from inflammation and have not been evaluated in a clinical setting.…”

Section: Antibioticsmentioning

confidence: 99%

“…While we provide a brief discussion of the most significant radiolabeled antibiotics, multiple extensive reviews are available on this topic. 106,114–117…”

Section: Antibioticsmentioning

confidence: 99%

“…128,129 Multiple additional fluoroquinolones, including lomefloxacin, 130 fleroxacin 131 and trovafloxacin, 132 have been radiolabeled with 18 F and/or 99m Tc, but preliminary studies have demonstrated inconsistent findings. 106,114 Although some have promising results for bacteria-specific imaging, extensive preclinical evaluation for the uptake mechanisms should be performed before further development in order to avoid past mistakes.…”

Section: Antibioticsmentioning

confidence: 99%

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Pathogen-Specific Bacterial Imaging in Nuclear Medicine

Ordoñez

Jain

2018

Seminars in Nuclear Medicine

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When serious infections are suspected, patients are often treated empirically with broad-spectrum antibiotics while awaiting results that provide information on the bacterial class and species causing the infection, as well as drug susceptibilities. For deep-seated infections, these traditional diagnostic techniques often rely on tissue biopsies to obtain clinical samples which can be expensive, dangerous, and has the potential of sampling bias. Moreover, these procedures and results can take several days and may not always provide reliable information. This combination of time and effort required for proper antibiotic selection has become a barrier leading to indiscriminate broad-spectrum antibiotic use. Exposure to nosocomial infections and indiscriminate use of broad-spectrum antibiotics are responsible for promoting bacterial drug-resistance leading to substantial morbidity and mortality, especially in hospitalized and immunosuppressed patients. Therefore, early diagnosis of infection and targeted antibiotic treatments are urgently needed to reduce morbidity and mortality caused by bacterial infections worldwide. Reliable pathogen-specific bacterial imaging techniques have the potential to provide early diagnosis and guide antibiotic treatments.

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Section: Antibioticsmentioning

confidence: 99%

“…While we provide a brief discussion of the most significant radiolabeled antibiotics, multiple extensive reviews are available on this topic. 106,114–117…”

Section: Antibioticsmentioning

confidence: 99%

Section: Antibioticsmentioning

confidence: 99%

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Pathogen-Specific Bacterial Imaging in Nuclear Medicine

Ordoñez

Jain

2018

Seminars in Nuclear Medicine

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“…Whereas the use of PET for PK/PD assessments in oncology has facilitated efforts for drug discovery and clinical translation (47), its application for infectious diseases is still an emerging field (48). PET utilizing radiolabeled antimicrobials provides a noninvasive solution to these challenges.…”

Section: Understanding Disease Pathogenesis In Situmentioning

confidence: 99%

Molecular Imaging: a Novel Tool To Visualize Pathogenesis of Infections In Situ

Gordon

Ruiz-Bedoya

Ordoñez

et al. 2019

mBio

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“…Molecular imaging using radiolabeled antibiotics can be used to non-invasively quantify drug penetration into the sites of infection and could potentially inform on bone penetration in a personalized manner. Several antibiotics have been radiolabeled and their in vivo biodistribution and penetration into the brain and areas of pulmonary infections characterized in animal models and humans [7,76,77,78,79,80,81]. For example, in tuberculous (TB) meningitis, the most devastating form of TB with high mortality, PET imaging of radiolabeled 11 C-rifampin showed that the drug has limited and spatially heterogeneous brain penetration that rapidly decreases as early as two weeks of TB treatment [81].…”

Section: Is the Antibiotic Penetrating The Infection Site?mentioning

confidence: 99%

Molecular Imaging of Diabetic Foot Infections: New Tools for Old Questions

Ruiz-Bedoya

Gordon

Mota

et al. 2019

IJMS

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Diabetic foot infections (DFIs) are a common, complex, and costly medical problem with increasing prevalence. Diagnosing DFIs is a clinical challenge due to the poor specificity of the available methods to accurately determine the presence of infection in these patients. However, failure to perform an opportune diagnosis and provide optimal antibiotic therapy can lead to higher morbidity for the patient, unnecessary amputations, and increased healthcare costs. Novel developments in bacteria-specific molecular imaging can provide a non-invasive assessment of the infection site to support diagnosis, determine the extension and location of the infection, guide the selection of antibiotics, and monitor the response to treatment. This is a review of recent research in molecular imaging of infections in the context of DFI. We summarize different clinical and preclinical methods and the translational implications aimed to improve the care of patients with DFI.

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Biodistribution and Pharmacokinetics of Antimicrobials

Cited by 7 publications

References 74 publications

Pathogen-Specific Bacterial Imaging in Nuclear Medicine

Pathogen-Specific Bacterial Imaging in Nuclear Medicine

Molecular Imaging: a Novel Tool To Visualize Pathogenesis of Infections In Situ

Molecular Imaging of Diabetic Foot Infections: New Tools for Old Questions

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