Biodistribution and Pharmacokinetics of Carbon Nanomaterials<i>In Vivo</i>

Yang, Shengrong; Liu, Xiaoyang; Xie, Jingru

doi:10.1002/9783527692866.ch3

Cited by 2 publications

(1 citation statement)

References 99 publications

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“…Individual particles might easily reach all components of both innate immunity, like circulating monocytes, granulocytes, components of the complement system, and adaptive immunity, like lymphocytes. Subsequent processing or translocation would depend again on the initial physicochemical properties and functionalization of used CNMs and formation of biocorona [ 57 ]. Several studies have pointed out that the majority of intravenously administered CNMs end up in the liver and spleen [ 58 , 59 , 60 , 61 , 62 ] followed by the lungs, kidneys, blood stream and heart [ 58 , 62 , 63 , 64 ].…”

Section: Entering the Bodymentioning

confidence: 99%

Immunotoxicity of Carbon-Based Nanomaterials, Starring Phagocytes

Švadláková

Holmannová

Koláčková

et al. 2022

IJMS

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In the field of science, technology and medicine, carbon-based nanomaterials and nanoparticles (CNMs) are becoming attractive nanomaterials that are increasingly used. However, it is important to acknowledge the risk of nanotoxicity that comes with the widespread use of CNMs. CNMs can enter the body via inhalation, ingestion, intravenously or by any other route, spread through the bloodstream and penetrate tissues where (in both compartments) they interact with components of the immune system. Like invading pathogens, CNMs can be recognized by large numbers of receptors that are present on the surface of innate immune cells, notably monocytes and macrophages. Depending on the physicochemical properties of CNMs, i.e., shape, size, or adsorbed contamination, phagocytes try to engulf and process CNMs, which might induce pro/anti-inflammatory response or lead to modulation and disruption of basic immune activity. This review focuses on existing data on the immunotoxic potential of CNMs, particularly in professional phagocytes, as they play a central role in processing and eliminating foreign particles. The results of immunotoxic studies are also described in the context of the entry routes, impacts of contamination and means of possible elimination. Mechanisms of proinflammatory effect depending on endocytosis and intracellular distribution of CNMs are highlighted as well.

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Section: Entering the Bodymentioning

confidence: 99%

Immunotoxicity of Carbon-Based Nanomaterials, Starring Phagocytes

Švadláková

Holmannová

Koláčková

et al. 2022

IJMS

View full text Add to dashboard Cite

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Carbon‐Based Nanomaterials for Antiviral Applications

Serrano‐Aroca,

Takayama,

Mishra

et al. 2024

Adv Funct Materials

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In the antimicrobial resistance era, carbon‐based nanomaterials (CBNs) such as fullerenes, carbon dots, graphene, and their derivatives are promising therapeutic tools in combating viral diseases. This review shows that these materials have broad‐spectrum antiviral activity against 33 viruses belonging to different Baltimore groups. CBNs also exhibit antimicrobial activity against bacteria and fungi and possess a low risk of selecting for resistance, since their primary mode of antimicrobial action involves physically damaging the microbes. CBNs also offer additional promising properties, including enhanced antiviral effectiveness under diverse types of irradiation and facilitating antiviral immune responses. Their potential as antiviral agents is still in its infancy and future research should focus on their toxicity, antiviral mechanisms, pharmacokinetics, and bioavailability. They are also potential antiviral materials for preventing the transmission of viral diseases for use in face masks, shields, hospital and airport surfaces, and elevators, among others. It is anticipated that CBNs will play an increasingly significant role in the fight against viruses and infectious diseases.

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Biodistribution and Pharmacokinetics of Carbon NanomaterialsIn Vivo

Cited by 2 publications

References 99 publications

Immunotoxicity of Carbon-Based Nanomaterials, Starring Phagocytes

Immunotoxicity of Carbon-Based Nanomaterials, Starring Phagocytes

Carbon‐Based Nanomaterials for Antiviral Applications

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