Biodistribution and Radiation Dosimetry of the Glycine Transporter-1 Ligand 11C-GSK931145 Determined from Primate and Human Whole-Body PET

Bullich, Santiago; Slifstein, Mark; Passchier, Jan; Murthy, Naga Venkatesha; Kegeles, Lawrence S.; Kim, Jong-Hoon; Xu, Xiaoyan; Gunn, Roger N.; Herance, José Raúl; Gispert, Juan Domingo; Gutiérrez, Antonio; Farré, Mercè; Laruelle, Marc; Catafau, Ana M.

doi:10.1007/s11307-010-0398-6

Cited by 15 publications

(16 citation statements)

References 14 publications

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“…Inter-and intra-operator variability of the different methods to obtain dosimetry estimates was evaluated using clinical data acquired in an earlier study [12]. In such study, eight healthy human volunteers (4 M /4 F) underwent wholebody PET/CT scans on a General Electric Discovery ST scanner which used a 3-dimensional mode protocol.…”

Section: Impact Of Inter-and Intra-operator Variability Of Roi Drawinmentioning

confidence: 99%

“…For activity quantification in PET planar images and according to previous works, there were no background susbstraction. In such studies it was demonstrated that analysis of compressed planar images were comparable to tomographic images, but with a slight overestimation (conservative calculation) [8][9][11][12].…”

Section: Impact Of Inter-and Intra-operator Variability Of Roi Drawinmentioning

confidence: 99%

“…However, delineating and overlapping organs may lead to biased results. There have been several attempts to compare the performance of these methods [10][11][12]. Nevertheless, the absence of a gold standard with which to compare the dosimetry estimates obtained have made it impossible to draw conclusions about the accuracy of these methods.…”

Section: Introductionmentioning

confidence: 99%

“…The aim of this study was to evaluate the performance of ROI delineation methods and reconstruction algorithms on the accuracy of internal dosimetry estimates using simulated PET studies for two radioligands with different biodistribution (intestinal and urinary excretion)In addition, the impact of ROI delineation methods on the interand intra-operator variability of dosimetry estimates has been assessed using clinical data from a previous study, where a radioligand with intestinal route of clearance was used [12]. with arms down [19] was used to generate a realistic anatomical model for subsequent Monte Carlo simulation.…”

Section: Introductionmentioning

confidence: 99%

“…Each model reproduced a different time point after injected activity. An homogeneous activity to each organ was assigned using time-activity curves of the simulated radioligands extracted from previously published human PET data [4][5]12]. …”

Section: Introductionmentioning

confidence: 99%

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Impact of Region-of-Interest Delineation Methods, Reconstruction Algorithms, and Intra- and Inter-Operator Variability on Internal Dosimetry Estimates Using PET

et al. 2016

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Purpose: Human dosimetry studies play a central role in PET radioligand development. Drawing regions of interest (ROIs) on the PET images is used to measure the dose in each organ. In the study aspects related to ROI delineation methods were evaluated for two radioligands of different biodistribution (intestinal vs urinary). Procedures: PET images were simulated from a human voxel-based phantom. Several ROI delineation methods were tested: antero-posterior projections (AP), 3D sub-samples of the organs (S), and a 3D volume covering the whole-organ (W). Inter-and intra-operator variability ROI drawing was evaluated by using human data. Results: The effective dose estimates using S and W methods were comparable to the true values. AP methods overestimated (49%) the dose for the radioligand with intestinal biodistribution. Moreover, the AP method showed the highest inter-operator variability: 11±1%. Conclusions: The sub-sampled organ method showed the best balance between quantitative accuracy and inter-and intra-operator variability.

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Section: Impact Of Inter-and Intra-operator Variability Of Roi Drawinmentioning

confidence: 99%

Section: Impact Of Inter-and Intra-operator Variability Of Roi Drawinmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Impact of Region-of-Interest Delineation Methods, Reconstruction Algorithms, and Intra- and Inter-Operator Variability on Internal Dosimetry Estimates Using PET

et al. 2016

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Intravascular Ultrasound‐Guided Primary Percutaneous Coronary Intervention With Drug‐Eluting Stent Implantation in Patients With ST‐Segment Elevation Myocardial Infarction

Youn

Yoon

Lee

et al. 2011

Clinical Cardiology

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Background: Studies investigating the clinical outcome of intravascular ultrasound (IVUS)-guided primary percutaneous coronary intervention (PPCI) in patients with ST-segment elevation myocardial infarction (STEMI) show conflicting results. The aim of our study was to evaluate whether IVUS-guidedPPCI with drug-eluting stents (DESs) in STEMI patients improves clinical outcome. Hypothesis: IVUS-guided PPCI is superior to angio-guided PPCI. Methods: Three hundred forty-one patients who underwent PPCI for STEMI and survived the hospitalization were enrolled in this study. Two hundred sixteen (63.3%) patients were treated with angio-guided PPCI and 125 (36.7%) patients were treated with IVUS-guided PPCI. The primary endpoint was defined as the composite of death, myocardial infarction, target vessel revascularization, and target lesion revascularization at the 3-year follow-up visit. Results: Male gender, dyslipidemia, and smoking were frequent in the IVUS-guided PPCI group. These patients had a higher rate of radial approach, adjunctive ballooning, thrombectomy, and the use of a glycoprotein IIb/IIIa inhibitor. The number and length of implanted stents were higher in the IVUS-guided PPCI group. The primary end point (18.1% vs 12.8%, P = 0.22) and stent thrombosis (2.8% vs 2.4%, P = 1.00) was not different between the groups. Conclusions: In our observational study, IVUS-guided PPCI with DESs in patients with STEMI did not improve clinical outcome or stent thrombosis. IntroductionAlthough the benefit of drug-eluting stents (DESs) compared with bare-metal stents in the treatment of coronary artery stenosis has been demonstrated in many studies, DESs are not free of restenosis and are limited by late stent thrombosis. 1 -5 Several intravascular ultrasound (IVUS) studies have shown that suboptimal deployment of DESs, including stent malapposition, incomplete stent expansion, and smaller minimal stent area correlated with restenosis and stent thrombosis. 6 -10 However, studies investigating whether IVUS-guided percutaneous coronary intervention (PCI) affected the clinical outcomeof patients with ST-segment elevation myocardial infarction (STEMI) showed conflicting results. Recently, Roy et al reported that IVUS-guided PCI reduced both DES thrombosis and the need for repeat revascularization in all-comer patients undergoing DES

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GlyT-1 Inhibitors: From Hits to Clinical Candidates

Porter¹,

Dawson

2014

Small Molecule Therapeutics for Schizophrenia

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Biodistribution and Radiation Dosimetry of the Glycine Transporter-1 Ligand 11C-GSK931145 Determined from Primate and Human Whole-Body PET

Cited by 15 publications

References 14 publications

Impact of Region-of-Interest Delineation Methods, Reconstruction Algorithms, and Intra- and Inter-Operator Variability on Internal Dosimetry Estimates Using PET

Impact of Region-of-Interest Delineation Methods, Reconstruction Algorithms, and Intra- and Inter-Operator Variability on Internal Dosimetry Estimates Using PET

Intravascular Ultrasound‐Guided Primary Percutaneous Coronary Intervention With Drug‐Eluting Stent Implantation in Patients With ST‐Segment Elevation Myocardial Infarction

GlyT-1 Inhibitors: From Hits to Clinical Candidates

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