Biodistribution and Toxicity Assessment of Superparamagnetic Iron Oxide Nanoparticles In Vitro and In Vivo

Yu, Qin; Xiong, Xianrong; Жао, Леи; Xu, Tingting; Bi, Hao; Fu, Rong; Wang, Qianhua

doi:10.1007/s11596-018-1989-8

Cited by 45 publications

(36 citation statements)

References 28 publications

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“…In contrast to our findings, higher accumulation of IONPs (dose of 1000 mg/kg for 28 days) was found in liver of rats causing congestion of portal tract whereas kidneys and brain were not affected [21]. Other literature demonstrated the assessment of superparamagnetic iron oxide nanoparticles on SD rats that revealed no alterations in histopathological and biochemical parameters [22].…”

Section: Discussioncontrasting

confidence: 99%

Green Synthesis to Develop Iron-Nano Formulations and Its Toxicity Assays

et al. 2020

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In the past few years, herbal medicines have gained popularity over synthetic drugs because of their natural source and minimal side effects which has led to a tremendous growth of phytopharmaceuticals usage. With the development of nanotechnology, it provides alternative approaches to overcome several limitations using nano-formulations. In spite of considerable quantity of antianemic preparations with different iron forms available, currently additives are used and represented in modern pharmaceutical market. Iron deficiency anemia is a major global public health problem which particularly affects pregnant women, children and elderly persons. The situation is complicated because of disadvantages and drug side effects from existing antianemic medicines. There is a great demand for the development of new antianemic preparations. Green synthesis of iron oxide nanoparticles, possess high potential in this field. Methods: Our study focuses on developing green synthesis of iron oxide nanoparticles (IONPs) of 10-50 nm with spherical shape where different dosages were used-1 mg/kg, 10 mg/kg and 100 mg/kg for exposure in Wistar albino female rats for 28 days. The toxicity was assessed using various parameters such as measurements of the rat body and organ mass, hematology, biochemical evaluation and histopathological examinations. Results: No significant differences were observed in body and organ weights. Hematological indices also indicated no significant differences whereas biochemical factors showed increase in levels of direct bilirubin and globulin of medium as well as high dose and SGPT levels were increased only in high dose. The major organs (heart, kidney and liver) showed histopathological alterations in 10 and 100 mg/kg whereas brain showed only in 100 mg/kg. Conclusion: The toxicity of IONPs was found to be more significant when the concentration was increased; however, low doses can be used for further investigation as an antianemic preparation.

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Section: Discussioncontrasting

confidence: 99%

Green Synthesis to Develop Iron-Nano Formulations and Its Toxicity Assays

et al. 2020

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“…According to Table 3, almost no significant difference was detected in all biochemical parameters after administration of CMSN (except GLB and TP). 18,[42][43][44] The results indicated that CMSN did not promote severe abnormalities of the hepatic and renal functions, and was proven to be safe in vivo. Based on the in vitro and in vivo results, it was reasonable to speculate that CMSN was a biocompatible bio-material with negligible toxicity, and was suitable for further applications in biological fields.…”

Section: In Vivo Toxicitymentioning

confidence: 90%

“…For all the measured parameters, the results were within the normal ranges, and there was no significant change between the control group and CMSN group (Table 2). 33,42,43 This suggested no obvious hematological toxicity, and CMSN would not promote any adverse trend to the blood cells and components. Moreover, it was crucial to measure the hepatic and renal functions after the continuous CMSN exposure, since liver and kidneys are the main place for metabolism and clearance of exogenous substances.…”

Section: In Vivo Toxicitymentioning

confidence: 91%

<p>Superiority of L-tartaric Acid Modified Chiral Mesoporous Silica Nanoparticle as a Drug Carrier: Structure, Wettability, Degradation, Bio-Adhesion and Biocompatibility</p>

Hu¹,

Wang²,

Li³

et al. 2020

IJN

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Purpose: The purpose of this research was to study the basic physicochemical and biological properties regarding the application of L-tartaric acid modified chiral mesoporous silica nanoparticle (CMSN) as a drug carrier, and to explore the structure-property relationship of silica-based materials. Methods: CMSN with functions of carboxyl modification and chirality was successfully synthesized through co-condensation method, and the basic characteristics of CMSN, including morphology, structure, wettability, degradation, bio-adhesion and retention ability in gastrointestinal tract (GI tract) were estimated by comparing with non-functionalized mesoporous silica nanoparticles (MSN). Meanwhile, the biocompatibility and toxicity of L-tartaric modification were systematically evaluated both in vitro and in vivo through MTT cell viability assay, cell cycle and apoptosis assay, hemolysis assay, histopathology examination, hematology analysis, and clinical chemistry examination. Results: CMSN and MSN were spherical nanoparticles with uniform mesoporous structure. CMSN with smaller pore size and carboxyl functional groups exhibited better wettability. Besides, CMSN and MSN could dissolve thoroughly in simulated physiological fluids during a degradation period of 1-12 weeks. Interestingly, the in vitro and in vivo behaviors of carriers, including degradation, bio-adhesion and retention ability in the GI tract were closely related to wettability. As expected, CMSN had faster degradation rate, higher mucosa-adhesion ability, and longer retention time. Particularly, CMSN improved the bio-adhesion property in both gastric mucosa and small intestinal mucosa, and prolonged the GI tract retention time to at least 12 h, which meant higher probability for absorption. The biocompatibility and toxicity examination indicated that CMSN was a kind of biocompatible bio-material with good blood compatibility and negligible toxicity, which is required for further applications in biological fields. Conclusion: CMSN with functions of carboxyl modification and chirality had superiority in terms of both physicochemical and biological properties. The in vitro and in vivo behaviors of carriers, including degradation, bio-adhesion, and retention were closely related to wettability.

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“…In a recent study, Wang et al have reported that SPION coated with PEI, which was employed to complex siRNA by electrostatic interactions between the positive charges of the polymer with the negatively charged phosphate backbone of the oligonucleotide strand, did not induce toxicity in rat model. [41] Despite the high accumulation in liver and spleen, these organs presented a normal histopathological analysis and similar ALT enzymatic expression that controls. Moreover, the administration of these particles did not cause renal toxicity in sight of the similar levels of blood urea nitrogen and creatinine with the untreated as is the case of GNP, is irradiated with light which has smaller wavelength than its size, it appears a coherent oscillation of the free electrons present on the surface, a phenomenon called surface plasmon resonance (SPR).…”

Section: Accepted Manuscript 2 Superparamagnetic Iromentioning

confidence: 86%

Overcoming the stability, toxicity, and biodegradation challenges of tumor stimuli-responsive inorganic nanoparticles for delivery of cancer therapeutics

Paris

Baeza²,

Vallet‐Regí

2019

Expert Opinion on Drug Delivery

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Introduction: Stimuli-responsive nanomaterials for cancer therapy have attracted much interest recently due to their potential for improving the current standard of care. Different types of inorganic nanoparticles are widely employed for the development of these strategies, but in some cases safety concerns hinder their clinical translation. This review aims to provide an overview of the challenges that inorganic nanoparticles face regarding their stability, toxicity and biodegradability, as well as the strategies that have been proposed to overcome them. Areas covered: The available information about the in vitro and in vivo biocompatibility, as well as the biodegradability of the following nanoparticles is presented and discussed: superparamagnetic iron oxide nanoparticles, gold nanoparticles, graphene and mesoporous nanoparticles made of silicon or silicon oxide. The toxicology of inorganic nanoparticles is greatly affected by many physicochemical parameters, and their surface modification emerges as the main intervention to improve their biocompatibility and tailor their performance for specific biomedical applications. Expert opinion: Even though many different studies have been performed regarding the biological behavior of inorganic nanoparticles, long-term in vivo data is still scarce, limiting our capacity to evaluate the proposed nanomaterials for clinical use. The role of biodegradability in different therapeutic contexts is also discussed.

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Biodistribution and Toxicity Assessment of Superparamagnetic Iron Oxide Nanoparticles In Vitro and In Vivo

Cited by 45 publications

References 28 publications

Green Synthesis to Develop Iron-Nano Formulations and Its Toxicity Assays

Green Synthesis to Develop Iron-Nano Formulations and Its Toxicity Assays

<p>Superiority of L-tartaric Acid Modified Chiral Mesoporous Silica Nanoparticle as a Drug Carrier: Structure, Wettability, Degradation, Bio-Adhesion and Biocompatibility</p>

Overcoming the stability, toxicity, and biodegradation challenges of tumor stimuli-responsive inorganic nanoparticles for delivery of cancer therapeutics

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