Biodistribution and toxicity assessment of radiolabeled and DMSA coated ferrite nanoparticles in mice

Fatahian, Soheil; Shahbazi‐Gahrouei, Daryoush; Pouladian, Majid; Yousefi, Mohammad; Amiri, G.R.; Noori, Ayush

doi:10.1007/s10967-012-1822-y

Cited by 17 publications

(12 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…(Fig. 3a), which suggests that DMSA molecules are bound to the particle surface via -COO -groups [32][33][34] . Because most of thiol groups have been oxidized into disulfide groups, the peaks of thiol group and disulfide group are not found in curves c and e 24, 32, 33 .…”

Section: Characterization Of Sulfhydryl Modified Fe 3 O 4 @Sio 2 Mnpsmentioning

confidence: 95%

Sulfhydryl-Modified Fe₃O₄@SiO₂ Core/Shell Nanocomposite: Synthesis and Toxicity Assessment in Vitro

Guo

Mao

Wang

et al. 2015

ACS Appl. Mater. Interfaces

109

View full text Add to dashboard Cite

The objectives of this study are to prepare sulfhydryl-modified Fe3O4@SiO2 core/shell magnetic nanocomposites, assess their toxicity in vitro, and explore their potential application in the biomedical fields. Fe3O4 nanoparticles synthesized by facile solvothermal method were coated with SiO2 via the Stöber method and further modified by the meso-2,3-dimercaptosuccinic acid (DMSA) to prepare Fe3O4@SiO2@DMSA nanoparticles. The morphology, structure, functional groups, surface charge, and magnetic susceptibility of the nanoparticles were characterized by transmission electron microscopy, X-ray diffraction, Fourier transform infrared spectrometry, X-ray photoelectron spectroscopy, zeta potential analysis, dynamic laser scattering, and vibrating sample magnetometer. Cytotoxicity tests and hemolysis assay were also carried out. Experimental results show that the toxicity of sulfhydryl-modified Fe3O4@SiO2 core/shell nanoparticles in mouse fibroblast (L-929) cell lines is between grade 0 and grade 1, and the material lacks hemolytic activity, indicating good biocompatibility of this Fe3O4@SiO2@DMSA nanocomposite, which is suitable for further application in biochemical fields.

show abstract

Section: Characterization Of Sulfhydryl Modified Fe 3 O 4 @Sio 2 Mnpsmentioning

confidence: 95%

Sulfhydryl-Modified Fe₃O₄@SiO₂ Core/Shell Nanocomposite: Synthesis and Toxicity Assessment in Vitro

Guo

Mao

Wang

et al. 2015

ACS Appl. Mater. Interfaces

109

View full text Add to dashboard Cite

show abstract

“…2 C). After DMSA was used for modification, it is difficult to observe the characteristic peaks of sulfhydryl groups by FT-IR spectroscopy [ [53] , [54] , [55] , [56] , [57] ]. Ellman spectrophotometry was used to detect the sulfhydryl content in Fe 3 O 4 @DMSA [ 58 , 59 ].…”

Section: Resultsmentioning

confidence: 99%

Nanomotor-based adsorbent for blood Lead(II) removal in vitro and in pig models

Wang

Bao

Yan

et al. 2021

Bioactive Materials

View full text Add to dashboard Cite

Blood lead (Pb(II)) removal is very important but challenging. The main difficulty of blood Pb(II) removal currently lies in the fact that blood Pb(II) is mainly complexed with hemoglobin (Hb) inside the red blood cells (RBCs). Traditional blood Pb(II) removers are mostly passive particles that do not have the motion ability, thus the efficiency of the contact between the adsorbent and the Pb(II)-contaminated Hb is relatively low. Herein, a kind of magnetic nanomotor adsorbent with movement ability under alternating magnetic field based on Fe 3 O 4 nanoparticle modified with meso-2, 3-dimercaptosuccinic acid (DMSA) was prepared and a blood Pb(II) removal strategy was further proposed. During the removal process, the nanomotor adsorbent can enter the RBCs, then the contact probability between the nanomotor adsorbent and the Pb(II)-contaminated Hb can be increased by the active movement of nanomotor. Through the strong coordination of functional groups in DMSA, the nanomotor adsorbent can adsorb Pb(II), and finally be separated from blood by permanent magnetic field. The in vivo extracorporeal blood circulation experiment verifies the ability of the adsorbent to remove blood Pb(II) in pig models, which may provide innovative ideas for blood heavy metal removal in the future.

show abstract

“…Then, every three or four seconds, one droplet of ME solution was added via magnetic stirrer. Finally, NaOH solution was added to the balloon in the same way (17). The resulting solution was washed by deionized water and then was centrifuged in order to remove any aggregate as impurity.…”

Section: Materials and Methods Iron Oxide Nanoparticles Synthesismentioning

confidence: 99%

The Effect of BSA and DMSA Coated Iron Oxide Nanoparticles on Liver and Renal Function in Mice

Hajshafiei¹,

Fatahian²

2016

West Indian Med J

View full text Add to dashboard Cite

Objective: To evaluate the effect of iron oxide (Fe 3 O 4) nanoparticles coating by biocompatible compound on their toxicity and also comparison with uncoated nanoparticles. Methods: The co-precipitation method was used in order to synthesize Fe 3 O 4 nanoparticles. The synthesized nanoparticles were coated by bovine serum albumin (BSA) and dimercaptosuccinic acid (DMSA) and the coating interactions were investigated by fourier transform infrared spectroscopy (FTIR). Nanoparticles properties were evaluated by alternating gradient force magnetometer (AGFM), transmission electron microscope (TEM) and X-ray diffraction (XRD). Toxicity assessment of nanoparticles were studied in mice by intraperitoneal injections. Liver enzymes (SGPT, SGOT, ALP and LDH) and also renal kidney factors (uric acid, creatinine and urea) were measured 7, 15 and 30 days post-injection. Results: The nanoparticles size was around 5 to 11 nm. Results showed that the amount of urea and creatinine were significantly increased seven days post-injection in the group receiving high doses. The amount of uric acid reduced significantly in all groups in comparison with the control. Iron oxide, nanoparticles also caused histologic changes in the kidney including accumulation in the glomerulus, nephron wall cells, internal nephron canal and kidney blood vessels and also inflammatory cells in glomerular capillaries and degeneration of proximal and distal tubules. Some liver enzymes were changed due to the injection of both uncoated and coated nanoparticles to mice. The liver enzymes changes were more considerable in the groups receiving DMSA or DMSA coated in comparison with the groups receiving BSA or BSA coated. There is no irreversible effect in concentrations less than 200 mg/kg for all control and treated groups. Conclusion: It seems that Fe 3 O 4 nanoparticles have a short-term effect on kidney and liver function. By the gradual elimination of particles uptake into the kidney, most effects disappeared during a month.

show abstract

Biodistribution and toxicity assessment of radiolabeled and DMSA coated ferrite nanoparticles in mice

Cited by 17 publications

References 20 publications

Sulfhydryl-Modified Fe₃O₄@SiO₂ Core/Shell Nanocomposite: Synthesis and Toxicity Assessment in Vitro

Sulfhydryl-Modified Fe₃O₄@SiO₂ Core/Shell Nanocomposite: Synthesis and Toxicity Assessment in Vitro

Nanomotor-based adsorbent for blood Lead(II) removal in vitro and in pig models

The Effect of BSA and DMSA Coated Iron Oxide Nanoparticles on Liver and Renal Function in Mice

Contact Info

Product

Resources

About

Biodistribution and toxicity assessment of radiolabeled and DMSA coated ferrite nanoparticles in mice

Cited by 17 publications

References 20 publications

Sulfhydryl-Modified Fe3O4@SiO2 Core/Shell Nanocomposite: Synthesis and Toxicity Assessment in Vitro

Sulfhydryl-Modified Fe3O4@SiO2 Core/Shell Nanocomposite: Synthesis and Toxicity Assessment in Vitro

Nanomotor-based adsorbent for blood Lead(II) removal in vitro and in pig models

The Effect of BSA and DMSA Coated Iron Oxide Nanoparticles on Liver and Renal Function in Mice

Contact Info

Product

Resources

About

Sulfhydryl-Modified Fe₃O₄@SiO₂ Core/Shell Nanocomposite: Synthesis and Toxicity Assessment in Vitro

Sulfhydryl-Modified Fe₃O₄@SiO₂ Core/Shell Nanocomposite: Synthesis and Toxicity Assessment in Vitro