Biodistribution evaluation of 166Ho–DTPA–SPION in normal rats

Nosrati, Sahar; Shanehsazzadeh, Saeed; Yousefnia, Hassan; Gholami, Abdollah; Grüttner, Cordula; Jalilian, Amir Reza; Hosseini, Reihaneh; Lahooti, Afsaneh

doi:10.1007/s10967-015-4251-x

Cited by 14 publications

(10 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…PEGylation can improve the uptake in lymph nodes and increase accumulation at the disease site by reducing the nonspecific interaction between particles and proteins of the biological milieu, thus causing a longer blood circulation time . On the other hand, several studies confirmed that Dextran coated NPs resulted in RES uptakes due to the protein corona formation (see the section 4.6) .…”

Section: Resultsmentioning

confidence: 99%

Dual nano‐sized contrast agents in PET/MRI: a systematic review

Lahooti

Sarkar

Laurent

et al. 2016

Contrast Media & Molecular

Self Cite

View full text Add to dashboard Cite

Nowadays molecular imaging plays a vital role in achieving a successful targeted and personalized treatment. Hence, the approach of combining two or more medical imaging modalities was developed. The objective of this review is to systematically compare recent dual contrast agents in Positron Emission Tomography (PET)/Magnetic Resonance Imaging (MRI) and in some cases Single photon emission computed tomography (SPECT)/MRI in terms of some their characteristics, such as tumor uptake, and reticuloendothelial system uptake (especially liver) and their relaxivity rates for early detection of primary cancer tumor. To the best of our knowledge, this is the first systematic and integrated overview of this field. Two reviewers individually directed the systematic review search using PubMed, MEDLINE and Google Scholar. Two other reviewers directed quality assessment, using the criteria checklist from the CAMARADES (Collaborative Approach to Meta-Analysis and Review of Animal Data from Experimental Studies) tool, and differences were resolved by consensus. After reviewing all 49 studies, we concluded that a size range of 20-200 nm can be used for molecular imaging, although it is better to try to achieve as small a size as it is possible. Also, small nanoparticles with a hydrophilic coating and positive charge are suitable as a T contrast agent. According to our selected data, the most successful dual probes in terms of high targeting were with an average size of 40 nm, PEGylated using peptides as a biomarker and radiolabeled with copper 64 and gallium 68. Copyright © 2017 John Wiley & Sons, Ltd.

show abstract

Section: Resultsmentioning

confidence: 99%

Dual nano‐sized contrast agents in PET/MRI: a systematic review

Lahooti

Sarkar

Laurent

et al. 2016

Contrast Media & Molecular

Self Cite

View full text Add to dashboard Cite

show abstract

“…A previous study reveals that a hydrodynamic size of 85 nm also induces a rapid clearance. 36 Moreover, it has been previously reported that positively charged nanoparticles can lead to nonspecific internalization rate and short blood circulation half-life. 61 Nevertheless, after 48 h, a small activity in blood (1% ID g –1 ) and heart (2% ID g –1 ) is still detected (Figure 9).…”

Section: Resultsmentioning

confidence: 99%

“…However, only a few PET/MRI bimodal imaging contrast agents based on iron oxide NPs have been developed. 6,13,21,31−36 Patel et al reported a PET/MRI imaging contrast agent using iron oxide NPs coated with DOTA to chelate Cu 2+ . 6 Lee et al developed a tumor-specific iron oxide probe for early clinical tumor detection using PET/MRI multimodal imaging.…”

Section: Introductionmentioning

confidence: 99%

Innovative Magnetic Nanoparticles for PET/MRI Bimodal Imaging

et al. 2019

View full text Add to dashboard Cite

Superparamagnetic iron oxide nanoparticles were developed as positron emission tomography (PET) and magnetic resonance imaging (MRI) bimodal imaging agents. These nanoparticles (NPs), with a specific nanoflower morphology, were first synthesized and simultaneously functionalized with 3,4-dihydroxy- l -phenylalanine (LDOPA) under continuous hydrothermal conditions. The resulting NPs exhibited a low hydrodynamic size of 90 ± 2 nm. The functional groups of LDOPA (−NH 2 and −COOH) were successfully used for the grafting of molecules of interest in a second step. The nanostructures were modified by poly(ethylene glycol) (PEG) and a new macrocyclic chelator MANOTA for further 64 Cu radiolabeling for PET imaging. The functionalized NPs showed promising bimodal (PET and MRI) imaging capability with high r 2 and r 2 * ( T 2 and T 2 * relaxivities) values and good stability. They were mainly uptaken from liver and kidneys. No cytotoxicity effect was observed. These NPs appear as a good candidate for bimodal tracers in PET/MRI.

show abstract

“…A polydentate acyclic chelator, DTPA is commonly used in the construction of MRI and nuclear imaging agents (Brücher, 2002; Frullano & Caravan, 2011; Price & Orvig, 2014). For radiopharmaceuticals, it has been used for labeling with many radiometal ions such as 99m Tc (D. Cheng et al, 2015; H. Gao et al, 2016), 111 In (G. Zhang et al, 2009), 67 Ga/ 68 Ga (de Souza Albernaz et al, 2018; Shanehsazzadeh et al, 2013), and 166 Ho (Nosrati et al, 2016). Given its acyclic nature, DTPA and its derivatives can be readily labeled with metal radionuclides (matter of minutes) (Price & Orvig, 2014).…”

Section: Radiolabeling Of Mnpsmentioning

confidence: 99%

Radiolabeling strategies and pharmacokinetic studies for metal based nanotheranostics

Bahadori

Mulgaonkar

Hart

et al. 2020

WIREs Nanomed Nanobiotechnol

View full text Add to dashboard Cite

Radiolabeled metal‐based nanoparticles (MNPs) have drawn considerable attention in the fields of nuclear medicine and molecular imaging, drug delivery, and radiation therapy, given the fact that they can be potentially used as diagnostic imaging and/or therapeutic agents, or even as theranostic combinations. Here, we present a systematic review on recent advances in the design and synthesis of MNPs with major focuses on their radiolabeling strategies and the determinants of their in vivo pharmacokinetics, and together how their intended applications would be impacted. For clarification, we categorize all reported radiolabeling strategies for MNPs into indirect and direct approaches. While indirect labeling simply refers to the use of bifunctional chelators or prosthetic groups conjugated to MNPs for post‐synthesis labeling with radionuclides, we found that many practical direct labeling methodologies have been developed to incorporate radionuclides into the MNP core without using extra reagents, including chemisorption, radiochemical doping, hadronic bombardment, encapsulation, and isotope or cation exchange. From the perspective of practical use, a few relevant examples are presented and discussed in terms of their pros and cons. We further reviewed the determinants of in vivo pharmacokinetic parameters of MNPs, including factors influencing their in vivo absorption, distribution, metabolism, and elimination, and discussed the challenges and opportunities in the development of radiolabeled MNPs for in vivo biomedical applications. Taken together, we believe the cumulative advancement summarized in this review would provide a general guidance in the field for design and synthesis of radiolabeled MNPs towards practical realization of their much desired theranostic capabilities. This article is categorized under: Nanotechnology Approaches to Biology > Nanoscale Systems in Biology Diagnostic Tools > Diagnostic Nanodevices Therapeutic Approaches and Drug Discovery > Nanomedicine for Oncologic Disease

show abstract

Biodistribution evaluation of 166Ho–DTPA–SPION in normal rats

Cited by 14 publications

References 36 publications

Dual nano‐sized contrast agents in PET/MRI: a systematic review

Dual nano‐sized contrast agents in PET/MRI: a systematic review

Innovative Magnetic Nanoparticles for PET/MRI Bimodal Imaging

Radiolabeling strategies and pharmacokinetic studies for metal based nanotheranostics

Contact Info

Product

Resources

About