Biodistribution of Amino-Functionalized Diamond Nanoparticles. In Vivo Studies Based on ¹⁸F Radionuclide Emission

Abstract

Nanoparticles have been proposed for several biomedical applications; however, in vivo biodistribution studies to confirm their potential are scarce. Nanodiamonds are carbon nanoparticles that have been recently proposed as a promising biomaterial. In this study, we labeled nanodiamonds with (18)F to study their in vivo biodistribution by positron emission tomography. Moreover, the impact on the biodistribution of their kinetic particle size and of the surfactant agents has been evaluated. Radiolabeled diamond nanoparticles accumulated mainly in the lung, spleen, and liver and were excreted into the urinary tract. The addition of surfactant agents did not lead to significant changes in this pattern, with the exception of a slight reduction in the urinary excretion rate. On the other hand, after filtration of the radiolabeled diamond nanoparticles to remove those with a larger kinetic size, the uptake in the lung and spleen was completely inhibited and significantly reduced in the liver.

In vivo enhancement of anticancer therapy using bare or chemotherapeutic drug-bearing nanodiamond particles

“…[14][15][16][17][18] Mohan et al used bare FND or FND conjugated with biomolecules for in vivo imaging of Caenorhabditis elegans 19 and found no detectable changes in reactive oxygen species. Recently, Rojas et al 20 studied the in vivo biodistribution of detonation nanodiamond labeled with 18 F in rats using positron emission tomography. More recently, Vaijayanthimala et al 21 investigated the long-term stability and biocompatibility of 100 nm FND administered by intraperitoneal injection over 5 months in rats.…”

Synthesis and Biodistribution of Cat's Eye-shaped [57Co]CoO@SiO2Nanoshell Aqueous Colloids for Single Photon Emission Computed Tomography (SPECT) Imaging Agent

“…6 Normally nanoparticles used in medical field can be categorized into inorganic, polymer and lipid nanoparticles. 7,8 Metal oxides such as iron oxide, cobalt oxide are probably one of the most interesting classes of inorganic nanoparticles because they form a wide variety of structures, and display many interesting properties and numerous applications.…”

Influence of PEGylation and RGD loading on the targeting properties of radiolabeled liposomal nanoparticles

“…22,[26][27][28][29][30] The advantage in using radioisotope imaging of LNPs is that these techniques are extremely sensitive and an absolute quantification of the compound is possible. 31 The radiolabeling of LNPs using a diethylenetriaminepentaacetic acid (DTPA)-derivatized lipid building block -which allows radiolabeling of liposomes with high specific activity and high stability in vitro and in vivo, respectively -has recently been investigated. 22 Here, the different 111 In-labeled LNPs, which differ in their RGD and PEG loading, were evaluated and the influence of these surface modifications on the pharmacokinetics of the liposome was investigated.…”