Biodistribution of calcium fructoborate as a targeting agent for boron neutron capture therapy in an experimental model of MDA-MB-231 breast cancer cells

New Insights into Boron Essentiality in Humans and Animals

“…Thus, NOB species will become essential for personalized nutrition as further novel prebiotic microbiota-accessible candidates. In the future, the colon’s ability to absorb B in the mucus gel layer may be a new target for the B neutron capture therapy (BNCT) of colon cancers by using 10 B-enriched prebiotic NOB compounds [ 138 , 168 , 169 ]. Moreover, supplements containing naturally occurring B should be taken preventively at any time because these supplements ensure the capture and extinction of increased radiation from the living environment.…”

“…Researchers have noticed that only a group of mice resistant to radiation had two main important classes of bacteria in their gut: Lachnospiraceae and Enterococcaceae . These bacteria need B for the biosynthesis of AI-2B, and the MoA that we proposed for NOB complexes could explain why these complexes ensure absorption of neutrons and gamma-radiation when they reach the colon [ 138 , 168 , 169 ]. Additionally, in areas where the natural radiation of the soil is increased, the concentration of B in the blood of animals and humans is very low because B in the body is consumed by natural radiation from the environment and transformed into lithium and helium, but only the 10 B isotope conducts the reaction [ 174 , 175 , 176 ].…”