Biodistribution of Free ²¹¹At and ¹²⁵I^– in Nude Mice Bearing Tumors Derived from Anaplastic Thyroid Carcinoma Cell Lines

Abstract

The biodistribution of 211At and 125I- differed in this animal model. The higher mean absorbed dose from 211At in several organs than in tumor tissue restricts the possibility of using free 211At for therapy of ATC.

Comparative Analysis of Transcriptional Gene Regulation Indicates Similar Physiologic Response in Mouse Tissues at Low Absorbed Doses from Intravenously Administered211At

“…However, during metabolism or degradation of radiolabeled compounds, 211 At might be released and accumulated in the thyroid gland via mechanisms similar-if to a lesser degree-to radioiodine (7)(8)(9)(10)(11). Unbound 211 At has been proposed for therapy of anaplastic thyroid carcinoma, yet the high uptake or retention in other normal tissues-for example, the kidneys, liver, lungs, and spleen-would limit successful therapy (12). The thyroid gland is required primarily for the hormonal regulation of metabolic processes in the body.…”

Radiation-Induced Thyroid Stunning: Differential Effects of 123I, 131I, 99mTc, and 211At on Iodide Transport and NIS mRNA Expression in Cultured Thyroid Cells

“…99m TcO 4 2 (pertechnetate) is routinely used in the functional evaluation of thyroid nodules and goiters. 211 At is an a-emitter suggested for therapy of poorly differentiated thyroid carcinoma (16,17) and nonthyroid tumors expressing NIS after gene transfer (18). 99m Tc, 211 At, 123 I, and 131 I have different decay properties.…”

Iodine-125 radiolabeling of silver nanoparticles for in vivo SPECT imaging

“…Free iodine is taken up rapidly by the thyroid gland, salivary gland, and stomach. 36 We observed minor thyroid uptake at 24 h in mice, probably because of catabolism of 125 I-Ag NPs and release of free iodine. Low levels of uptake in the lung might be attributable to the phagocytic activity of pulmonary macrophages.…”