2012
DOI: 10.1016/j.jpba.2012.06.008
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Biodistribution of nanoparticles: Initial considerations

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Cited by 37 publications
(17 citation statements)
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“…The in vivo fate of nanoparticles is governed by their physiological properties such as size, shape, composition, surface chemistry and physical properties [18,19]. The biodistribution profile observed for PVX matches previous reports for nanomaterials of similar size, shape and composition.…”
Section: Resultssupporting
confidence: 71%
See 1 more Smart Citation
“…The in vivo fate of nanoparticles is governed by their physiological properties such as size, shape, composition, surface chemistry and physical properties [18,19]. The biodistribution profile observed for PVX matches previous reports for nanomaterials of similar size, shape and composition.…”
Section: Resultssupporting
confidence: 71%
“…Spherical nanomaterials 30–80 nm in diameter tend to be sequestered in the lungs and leaky vasculature, whereas those larger than 80 nm are generally trapped in the spleen and liver [20,21]. Nanomaterials similar in size to PVX are not usually excreted by the renal system, but are mainly removed from circulation efficiently by the MPS [18,19,22]. …”
Section: Resultsmentioning
confidence: 99%
“…The nanoparticles accumulation in the liver may be due to reabsorption before it was eliminated by kidney from the system. The absorbance in the kidney may be linked to nanoparticles absorption into the circulation and deposition into the renal tissues [21].…”
Section: Biodistribution Assaysmentioning
confidence: 99%
“…The liver's role in clearance is more prominent when the oligonucleotides are associated with nanoparticles [140]. Clearance by the kidney, on the other hand, has been demonstrated in nanoparticle and non-nanoparticle-based miRNA therapeutics [141]. Studies that characterized the clearance of antisense oligonucleotides were extensively reported during the 1990s [142][143][144].…”
Section: Biodistribution and Renal Clearancementioning
confidence: 99%