Biodistribution, pharmacokinetics and PET Imaging of [18F]FMISO, [18F]FDG and [18F]FAc in a sarcoma- and inflammation-bearing mouse model

Liu, Ru‐Shi; Chou, Ta Kai; Chang, Cheng-Yen; Wu, Chun Yi; Chang, Chi Wei; Chang, Tsui Jung; Wang, Shih Jen; Lin, Wuu-Jyh; Wang, Hsin Ell

doi:10.1016/j.nucmedbio.2008.12.011

Cited by 61 publications

(47 citation statements)

References 19 publications

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“…The T/B ratios of 67 Ga-DOTA-MN2 at 1 h postinjection were 3.19, which was higher than that of 18 F-FMiSO (1.19) 21) and equal to that of 18 F-FAZA (3.27), 22) although tumor cells examined in each experiment were different. At the same time point, 67 Ga-DOTA-MN2 exhibited higher T/M ratios (8.99) than 18 F-FMiSO (1.65) and 18 F-FAZA (1.69).…”

Section: /68mentioning

confidence: 69%

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In Vivo Evaluation of a Radiogallium-Labeled Bifunctional Radiopharmaceutical, Ga-DOTA-MN2, for Hypoxic Tumor Imaging

Sano

Okada

Hisada

et al. 2013

Biological & Pharmaceutical Bulletin

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On the basis of the findings obtained by X-ray crystallography of Ga-DOTA chelates and the drug design concept of bifunctional radiopharmaceuticals, we previously designed and synthesized a radiogalliumlabeled DOTA chelate containing two metronidazole moieties, 67Ga-DOTA-MN2, for hypoxic tumor imaging. As expected, 67Ga-DOTA-MN2 exhibited high in vivo stability, although two carboxyl groups in the DOTA skeleton were conjugated with metronidazole moieties. In this study, we evaluated 67/68 Ga-DOTA-MN2 as a nuclear imaging agent for hypoxic tumors. Key words radiogallium; bifunctional radiopharmaceutical; hypoxic tumor imaging; positron emission tomography Tumor hypoxia results from an imbalance between oxygen supply and consumption, which is caused by abnormal structure and function of microvessels supplying the tumor, increased diffusion distances between the nutritive blood vessels and the tumor cells, and reduced O 2 transport capacity of the blood.1,2) Tumor hypoxia has been associated with an aggressive tumor phenotype, poor response to radiotherapy and chemotherapy, and increased risk of invasion and metastasis of tumors.3,4) Thus, non-invasive measurement of tumor hypoxia with positron emission tomography (PET) would have a distinct effect on characterizing tumor malignancy and determining a course of therapy.Metronidazole, nitroimidazole antibiotic medication used for anaerobic bacteria and protozoa in particular, has a tendency to accumulate in the hypoxic regions and enhance the lethal effect of ionizing radiation for hypoxic tissues.5) The reduction of the nitroimidazole (RNO 2 ) within cells proceeds in successive steps involving enzyme-mediated electron transfer via the free radical anion (RNO

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Section: /68mentioning

confidence: 69%

“…At the same time point, 67 Ga-DOTA-MN2 exhibited higher T/M ratios (8.99) than 18 F-FMiSO (1.65) and 18 F-FAZA (1.69). 21,22) Moreover,…”

Section: /68mentioning

confidence: 99%

In Vivo Evaluation of a Radiogallium-Labeled Bifunctional Radiopharmaceutical, Ga-DOTA-MN2, for Hypoxic Tumor Imaging

Sano

Okada

Hisada

et al. 2013

Biological & Pharmaceutical Bulletin

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“…Labeling of acetate with 18 F is a potential means to make possible the clinical use of radiolabeled acetate (39,46). Fluoroacetate is the toxic ingredient of the South African poison plant Dichapetalum chymosum and of other Dichapetalum plants (47).…”

Section: Discussionmentioning

confidence: 99%

1-¹¹C-Acetate Versus ¹⁸F-FDG PET in Detection of Meningioma and Monitoring the Effect of γ-Knife Radiosurgery

Liu¹,

Chang²,

Guo³

et al. 2010

J Nucl Med

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“…Yen reported [28] that PET/CT could detect additionally 12.9% of distant metastasis, among patients diagnosed as M0 by conventional workup. The patient-based sensitivity and specificity of 18 F-FDG PET for distant metastases were 100% and 86.9%, respectively.…”

Section: Distant Metastasismentioning

confidence: 99%

Use Of 18F-FDG PET/CT In The Diagnosis, Staging, Response Assessment And Prognosis Of Nasopharyngeal Carcinoma: An Updated Review

Yang

2014

J Nasopharyng Carcinoma

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Biodistribution, pharmacokinetics and PET Imaging of [18F]FMISO, [18F]FDG and [18F]FAc in a sarcoma- and inflammation-bearing mouse model

Cited by 61 publications

References 19 publications

In Vivo Evaluation of a Radiogallium-Labeled Bifunctional Radiopharmaceutical, Ga-DOTA-MN2, for Hypoxic Tumor Imaging

In Vivo Evaluation of a Radiogallium-Labeled Bifunctional Radiopharmaceutical, Ga-DOTA-MN2, for Hypoxic Tumor Imaging

1-¹¹C-Acetate Versus ¹⁸F-FDG PET in Detection of Meningioma and Monitoring the Effect of γ-Knife Radiosurgery

Use Of 18F-FDG PET/CT In The Diagnosis, Staging, Response Assessment And Prognosis Of Nasopharyngeal Carcinoma: An Updated Review

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Biodistribution, pharmacokinetics and PET Imaging of [18F]FMISO, [18F]FDG and [18F]FAc in a sarcoma- and inflammation-bearing mouse model

Cited by 61 publications

References 19 publications

In Vivo Evaluation of a Radiogallium-Labeled Bifunctional Radiopharmaceutical, Ga-DOTA-MN2, for Hypoxic Tumor Imaging

In Vivo Evaluation of a Radiogallium-Labeled Bifunctional Radiopharmaceutical, Ga-DOTA-MN2, for Hypoxic Tumor Imaging

1-11C-Acetate Versus 18F-FDG PET in Detection of Meningioma and Monitoring the Effect of γ-Knife Radiosurgery

Use Of 18F-FDG PET/CT In The Diagnosis, Staging, Response Assessment And Prognosis Of Nasopharyngeal Carcinoma: An Updated Review

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1-¹¹C-Acetate Versus ¹⁸F-FDG PET in Detection of Meningioma and Monitoring the Effect of γ-Knife Radiosurgery