Biodistribution study of 211Pb progeny released from intravenously applied 223Ra labelled TiO2 nanoparticles in a mouse model

Sakmár, Michal; Kozempel, Ján; Kučka, Jan; Janská, Tereza; Štíbr, Matěj; Vlk, Martin; Šefc, Luděk

doi:10.1016/j.nucmedbio.2024.108890

Nuclear Medicine and Biology

2024

DOI: 10.1016/j.nucmedbio.2024.108890

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Biodistribution study of 211Pb progeny released from intravenously applied 223Ra labelled TiO2 nanoparticles in a mouse model

Michal Sakmár,

Ján Kozempel,

Jan Kučka

et al.

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Cited by 2 publications

References 26 publications

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Recent Advances in Metal Oxide and Phosphate Nanomaterials Radiolabeling with Medicinal Nuclides

Janská,

Sakmár,

Štíbr

et al. 2024

ACS Omega

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The utilization of nanomaterials in biomedical applications has surged in recent years; yet, the transition from research to practical implementation remains a great challenge. However, a promising area of research has emerged with the integration of nanomaterials with diagnostic and therapeutic radionuclides. In this Review, we elucidate the motivations behind selecting metal oxide- and phosphate-based nanomaterials in conjunction with these radionuclides, while addressing its issues and limitations. Various metal oxide- and phosphate-based nanoparticles, exhibiting low toxicity and high tolerability, have been proposed for diverse biomedical applications, ranging from bone substitutes to drug delivery systems and controlled release vectors for pharmaceuticals, including radionuclides for nuclear medicine imaging and therapy. Moreover, the potential synergistic effects of multimodal combinational therapies, integrating chemotherapeutics, immunomodulators, or hyperthermia, underscore the versatility of these nanoconstructs. Our comprehensive exploration includes the underlying principles of radiolabeling strategies, the pivotal attributes of nanomaterial platforms, and their applications. Through this perspective, we present the potential of nanotechnology-enabled nuclear medicine. Furthermore, we discuss the potential systemic and local applications of these nanoconstructs, considering their in vitro and in vivo characteristics, as well as their physicochemical properties.

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Recent Advances in Metal Oxide and Phosphate Nanomaterials Radiolabeling with Medicinal Nuclides

Janská,

Sakmár,

Štíbr

et al. 2024

ACS Omega

View full text Add to dashboard Cite

show abstract

Polymeric nanoparticles in radiopharmaceutical delivery strategies

Tian,

Guo,

Liu

et al. 2025

J. Mater. Chem. B

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Biodistribution study of 211Pb progeny released from intravenously applied 223Ra labelled TiO2 nanoparticles in a mouse model

Cited by 2 publications

References 26 publications

Recent Advances in Metal Oxide and Phosphate Nanomaterials Radiolabeling with Medicinal Nuclides

Recent Advances in Metal Oxide and Phosphate Nanomaterials Radiolabeling with Medicinal Nuclides

Polymeric nanoparticles in radiopharmaceutical delivery strategies

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