Biodistribution Study of Novel Dodecaborate-Phthalocyanines in the B-16 Mouse Melanoma Model

Spryshkova, R. A.; Grigorieva, Elvira V.; Riabkova, V.; Spure, Zh Zh; Naidenov, M.; Zhizhin, K. Yu.; Малинина, Е. А.; Chernyavsky, A.; Luk’yanets, E. A.; Солнцев, К. А.; Кузнецов, Н. Т.; Borisov, G. I.

doi:10.1007/978-1-4615-1285-1_156

Cited by 3 publications

(2 citation statements)

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“…[43] In vivo studies on B-16 mouse melanoma model demonstrated moderate tumor accumulation and rather high blood/tumor ratio for phthalocyanine 10 and no tumor accumulation for phthalocyanine 11. [44] Boronated zinc phthalocyanine 14 was prepared in 71 % yield by the reaction of zinc 2-(4-carboxyphenoxy) phthalocyanine with sodium mercapto-closo-dodecaborate (Scheme 8) and its photosensitizing properties at molecular and cellular level were studied. [45] Some later the ring opening of cyclic oxonium derivative of the closo-dodecaborate anion [46] with nucleophiles was used for synthesis of zinc phthalocyanine 15 with four boron fragments connected to the phthalocyanine core through flexible spacers (Scheme 9).…”

Section: Polyhedral Boron Compoundsmentioning

confidence: 99%

Boron-Containing Phthalocyanines and Porphyrazines

Sivaev¹,

Bregadze

Gül³

et al. 2012

MHC

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Section: Polyhedral Boron Compoundsmentioning

confidence: 99%

Boron-Containing Phthalocyanines and Porphyrazines

Sivaev¹,

Bregadze

Gül³

et al. 2012

MHC

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“…Biological research involving boron-containing phthalocyanines at present is at a much more elementary stage of development [44].…”

Section: Scheme 18mentioning

confidence: 99%

Polyhedral boron derivatives of porphyrins and phthalocyanines

Bregadze

Sivaev

Gabel

et al. 2001

J. Porphyrins Phthalocyanines

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ABSTRACT:The synthesis of compounds containing polyhedral boron cages and porphyrin or phthalocyanine units connected covalently in one molecule is reviewed. The importance of these compounds arises, on the one hand, from the use of polyhedral boron derivatives in neutron capture therapy for cancer; on the other hand, porphyrins and phthalocyanines are known as photosensitizers in photodynamic tumor therapy. Current interest in the binding of polyhedral boron compounds to porphyrins and phthalocyanines is due to the observation that porphyrins and phthalocyanines show improved uptake and good persistence in tissues. Medical applications of compounds containing polyhedral boron cages and porphyrin or phthalocyanine units in one molecule are briefly discussed.

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